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期刊论文 [5]
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2020 [5]
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英语 [5]
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Science [5]
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来源机构:Science
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Structure of the RNA-dependent RNA polymerase from COVID-19 virus
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Gao Y.
;
Yan L.
;
Huang Y.
;
Liu F.
;
Zhao Y.
;
Cao L.
;
Wang T.
;
Sun Q.
;
Ming Z.
;
Zhang L.
;
Ge J.
;
Zheng L.
;
Zhang Y.
;
Wang H.
;
Zhu Y.
;
Zhu C.
;
Hu T.
;
Hua T.
;
Zhang B.
;
Yang X.
;
Li J.
;
Yang H.
;
Liu Z.
;
Xu W.
;
Guddat L.W.
;
Wang Q.
;
Lou Z.
;
Rao Z.
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2020/07/28
comparative study
drug
electron microscopy
enzyme
enzyme activity
RNA
virus
Coronavirus
SARS coronavirus
adenosine phosphate
alanine
antivirus agent
NSP7 protein, SARS-CoV-2
NSP8 protein, SARS-CoV-2
remdesivir
RNA directed RNA polymerase
RNA-dependent RNA polymerase, coronavirus
viral protein
beta sheet
Betacoronavirus
chemistry
cryoelectron microscopy
drug design
enzyme active site
enzymology
metabolism
molecular model
protein domain
ultrastructure
Adenosine Monophosphate
Alanine
Antiviral Agents
Betacoronavirus
Catalytic Domain
Cryoelectron Microscopy
Drug Design
Models, Molecular
Protein Conformation, beta-Strand
Protein Domains
RNA Replicase
Viral Nonstructural Proteins
PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis
期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:
Wang Q.
;
Boshoff H.I.M.
;
Harrison J.R.
;
Ray P.C.
;
Green S.R.
;
Wyatt P.G.
;
Barry Iii C.E.
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/28
3,3 bis di(methylsulfonyl)propionamide
antiinfective agent
bacterial protein
glucose
glycerol
magnesium
phosphate
propionamide derivative
protein proline proline glutamate
protein proline proline glutamate 51
unclassified drug
amide
bacterial protein
lipid
phthiocerol dimycocerosate
propionamide
thiol derivative
cell component
chemical compound
membrane
mutation
protein
tuberculosis
antibiotic resistance
Article
bacterial cell
bacterial cell wall
bacterial growth
bacterial outer membrane
cell division
drug structure
Mycobacterium tuberculosis
nonhuman
nutrient uptake
priority journal
protein depletion
cell membrane
cell membrane permeability
chemistry
drug effect
gene deletion
genetics
metabolism
transport at the cellular level
Mycobacterium tuberculosis
Amides
Bacterial Proteins
Biological Transport
Cell Membrane
Cell Membrane Permeability
Drug Resistance, Bacterial
Gene Deletion
Glucose
Glycerol
Lipids
Mycobacterium tuberculosis
Sulfhydryl Compounds
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells
期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:
Pareek V.
;
Tian H.
;
Winograd N.
;
Benkovic S.J.
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/28
adenosine phosphate
guanosine phosphate
multienzyme complex
nucleotide
purine
purine
purine derivative
cell
experimental study
imaging method
mass spectrometry
metabolism
protein
Article
biochemistry
enzyme assay
gas cluster ion beam secondary ion mass spectrometry
image analysis
mass spectrometry
metabolomics
mitochondrion
molecular imaging
molecular probe
priority journal
purine synthesis
reaction analysis
single cell analysis
biosynthesis
fluorescence imaging
HeLa cell line
human
metabolism
metabolomics
procedures
secondary ion mass spectrometry
HeLa Cells
Humans
Metabolomics
Mitochondria
Multienzyme Complexes
Optical Imaging
Purines
Single-Cell Analysis
Spectrometry, Mass, Secondary Ion
Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division
期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:
Nagashima S.
;
Tábara L.-C.
;
Tilokani L.
;
Paupe V.
;
Anand H.
;
Pogson J.H.
;
Zunino R.
;
McBride H.M.
;
Prudent J.
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/28
adenosine diphosphate ribosylation factor 1
dynamin related protein 1
mitochondrial protein
phosphatidylinositol 4 kinase IIIbeta
phosphatidylinositol 4 phosphate
phosphatidylinositol kinase
unclassified drug
adenosine diphosphate ribosylation factor 1
ARF1 protein, human
DNM1L protein, human
dynamin
phosphatidylinositol 4-phosphate
phosphatidylinositol kinase
polyphosphoinositide
cell component
cell organelle
chemical compound
enzyme
enzyme activity
mitochondrion
protein
Article
controlled study
COS-7 cell line
endoplasmic reticulum
fibroblast
gene silencing
HeLa cell line
human
human cell
membrane microdomain
mitochondrial division
mitochondrial dynamics
mitochondrial scission
priority journal
protein localization
trans Golgi network
U2OS cell line
animal
cell line
Chlorocebus aethiops
CV-1 cell line
genetics
metabolism
mitochondrial membrane
mitochondrion
RNA interference
trans Golgi network
ultrastructure
Mammalia
1-Phosphatidylinositol 4-Kinase
ADP-Ribosylation Factor 1
Animals
Cell Line
Chlorocebus aethiops
COS Cells
Dynamins
Endoplasmic Reticulum
HeLa Cells
Humans
Membrane Microdomains
Mitochondria
Mitochondrial Dynamics
Mitochondrial Membranes
Phosphatidylinositol Phosphates
RNA Interference
trans-Golgi Network
An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis
期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:
Zhao P.
;
Sun X.
;
Chaggan C.
;
Liao Z.
;
Wong K.I.
;
He F.
;
Singh S.
;
Loomba R.
;
Karin M.
;
Witztum J.L.
;
Saltiel A.R.
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/28
6,7 dihydro 4 hydroxy 3 (2' hydroxy 1,1' biphenyl 4 yl) 6 oxothieno[2,3 b]pyridine 5 carbonitrile
adenosine phosphate
caspase 3
caspase 6
caspase 7
cytochrome c
hydroxymethylglutaryl coenzyme A reductase kinase
matrix metalloproteinase
apoptosis
cytochrome
enzyme
enzyme activity
inhibition
protein
rodent
AMPK signaling
animal experiment
animal model
animal tissue
apoptosis
Article
C57BL 6 mouse
cell death
controlled study
drug mechanism
enzyme activation
enzyme activity
enzyme inhibition
enzyme phosphorylation
enzyme repression
gene knockout
human
human cell
human tissue
liver cell
liver fibrosis
liver injury
male
mouse
nonalcoholic steatohepatitis
nonhuman
priority journal
protein cleavage
protein secretion