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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Dai W.;  Zhang B.;  Jiang X.-M.;  Su H.;  Li J.;  Zhao Y.;  Xie X.;  Jin Z.;  Peng J.;  Liu F.;  Li C.;  Li Y.;  Bai F.;  Wang H.;  Cheng X.;  Cen X.;  Hu S.;  Yang X.;  Wang J.;  Liu X.;  Xiao G.;  Jiang H.;  Rao Z.;  Zhang L.-K.;  Xu Y.;  Yang H.;  Liu H.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/28
aldehyde  antimicrobial activity  drug  enzyme activity  infectivity  inhibitor  reaction kinetics  viral disease  Coronavirus  SARS coronavirus  3C-like proteinase, Coronavirus  antivirus agent  cysteine proteinase  viral protein  animal  Betacoronavirus  chemical structure  chemistry  Chlorocebus aethiops  Coronavirus infection  dog  drug design  drug effect  enzyme active site  enzymology  female  human  male  mouse  pandemic  preclinical study  protein tertiary structure  Sprague Dawley rat  toxicity testing  Vero cell line  virus pneumonia  Animals  Antiviral Agents  Betacoronavirus  Catalytic Domain  Chlorocebus aethiops  Coronavirus Infections  Cysteine Endopeptidases  Dogs  Drug Design  Drug Evaluation, Preclinical  Female  Humans  Male  Mice  Molecular Structure  Pandemics  Pneumonia, Viral  Protein Structure, Tertiary  Rats, Sprague-Dawley  Toxicity Tests  Vero Cells  Viral Nonstructural Proteins  
An atlas of the protein-coding genes in the human, pig, and mouse brain 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Sjöstedt E.;  Zhong W.;  Fagerberg L.;  Karlsson M.;  Mitsios N.;  Adori C.;  Oksvold P.;  Edfors F.;  Limiszewska A.;  Hikmet F.;  Huang J.;  Du Y.;  Lin L.;  Dong Z.;  Yang L.;  Liu X.;  Jiang H.;  Xu X.;  Wang J.;  Yang H.;  Bolund L.;  Mardinoglu A.;  Zhang C.;  Von Feilitzen K.;  Lindskog C.;  Pontén F.;  Luo Y.;  Hökfelt T.;  Uhlén M.;  Mulder J.
收藏  |  浏览/下载:34/0  |  提交时间:2020/07/28
G protein coupled receptor  neurotransmitter  atlas  brain  gene  gene expression  pig  protein  Article  astrocyte  cerebellum  gene expression level  gene expression profiling  gene mapping  genetic code  genome-wide association study  genomics  human  hypothalamus  in situ hybridization  microglia  nerve cell  nonhuman  oligodendroglia  pig  priority journal  species comparison  tissue specificity  transcriptomics  Mammalia  Suidae  
Control of zeolite pore interior for chemoselective alkyne/olefin separations 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Chai Y.;  Han X.;  Li W.;  Liu S.;  Yao S.;  Wang C.;  Shi W.;  Da-Silva I.;  Manuel P.;  Cheng Y.;  Daemen L.D.;  Ramirez-Cuesta A.J.;  Tang C.C.;  Jiang L.;  Yang S.;  Guan N.;  Guan N.;  Li L.;  Li L.
收藏  |  浏览/下载:63/0  |  提交时间:2020/07/28
acetylene  adsorption  neutron diffraction  neutron scattering  polymer  zeolite  
Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Liu J.;  Kim Y.S.;  Richardson C.E.;  Tom A.;  Ramakrishnan C.;  Birey F.;  Katsumata T.;  Chen S.;  Wang C.;  Wang X.;  Joubert L.-M.;  Jiang Y.;  Wang H.;  Fenno L.E.;  Tok J.B.-H.;  Paşca S.P.;  Shen K.;  Bao Z.;  Deisseroth K.
收藏  |  浏览/下载:38/0  |  提交时间:2020/07/28
poly(3,4 ethylenedioxythiophene)  polyaniline  polymer  unclassified drug  3-nitro-o-phenylenediamine  aniline  aniline derivative  ascorbate peroxidase  nitro derivative  phenylenediamine derivative  polymer  anatomy  genetic engineering  membrane  physiological response  polymer  animal cell  Article  biocompatibility  brain nerve cell  brain slice  Caenorhabditis elegans  cell membrane  cell viability  controlled study  genetic procedures  genetically targeted chemical assemby  hippocampal neuronal culture  human  human cell  in vivo study  nerve cell membrane  nonhuman  polymerization  priority journal  rat  synthesis  action potential  animal  cell culture  cell survival  chemistry  electric conductivity  enzymology  genetic engineering  genetic transduction  genetics  HEK293 cell line  hippocampus  membrane potential  metabolism  motoneuron  mouse  muscle cell  nerve cell  patch clamp technique  physiology  Animalia  Action Potentials  Aniline Compounds  Animals  Ascorbate Peroxidases  Caenorhabditis elegans  Cell Membrane  Cell Survival  Cells, Cultured  Electric Conductivity  Genetic Engineering  HEK293 Cells  Hippocampus  Humans  Membrane Potentials  Mice  Motor Neurons  Muscle Cells  Neurons  Nitro Compounds  Patch-Clamp Techniques  Phenylenediamines  Polymers  Rats  Transduction, Genetic  
Resolving spatial and energetic distributions of trap states in metal halide perovskite solar cells 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Ni Z.;  Bao C.;  Liu Y.;  Jiang Q.;  Wu W.-Q.;  Chen S.;  Dai X.;  Chen B.;  Hartweg B.;  Yu Z.;  Holman Z.;  Huang J.
收藏  |  浏览/下载:23/0  |  提交时间:2020/07/28
nanocrystal  perovskite  crystallinity  energetics  halide  metal  perovskite  photovoltaic system  solar power  analytic method  Article  chemical composition  crystal structure  density  drive level capacitance profiling  energy transfer  magnitude estimation method  physical parameters  priority journal  quality control  spatial analysis  spectroscopy  surface property  thermal admittance spectroscopy  trap density of states