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Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载:39/0  |  提交时间:2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
Helical quantum Hall phase in graphene on SrTiO3 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Veyrat L.;  Déprez C.;  Coissard A.;  Li X.;  Gay F.;  Watanabe K.;  Taniguchi T.;  Han Z.;  Piot B.A.;  Sellier H.;  Sacépé B.
收藏  |  浏览/下载:29/0  |  提交时间:2020/07/28
graphene  metal oxide  strontium titanate  unclassified drug  experimental study  magnetic field  temperature effect  topology  Article  controlled study  dielectric constant  magnetic field  prediction  priority journal  quantum mechanics  temperature  
De novo protein design enables the precise induction of RSV-neutralizing antibodies 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Sesterhenn F.;  Yang C.;  Bonet J.;  Cramer J.T.;  Wen X.;  Wang Y.;  Chiang C.-I.;  Abriata L.A.;  Kucharska I.;  Castoro G.;  Vollers S.S.;  Galloux M.;  Dheilly E.;  Rosset S.;  Corthésy P.;  Georgeon S.;  Villard M.;  Richard C.-A.;  Descamps D.;  Delgado T.;  Oricchio E.;  Rameix-Welti M.-A.;  Más V.;  Ervin S.;  Eléouët J.-F.;  Riffault S.;  Bates J.T.;  Julien J.-P.;  Li Y.;  Jardetzky T.;  Krey T.;  Correia B.E.
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/28
algorithm  antibody  design  neutralization  protein  vaccine  Mus  Primates  Respiratory syncytial virus  Rice stripe virus  epitope  fusion protein  nanobody  neutralizing antibody  respiratory syncytial virus vaccine  biology  biosynthesis  chemistry  human  Human respiratory syncytial virus  immunology  procedures  protein conformation  protein engineering  protein motif  Amino Acid Motifs  Antibodies, Neutralizing  Computational Biology  Humans  Immunodominant Epitopes  Protein Conformation  Protein Engineering  Recombinant Fusion Proteins  Respiratory Syncytial Virus Vaccines  Respiratory Syncytial Virus, Human  Single-Domain Antibodies  
Forest microclimate dynamics drive plant responses to warming 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Zellweger F.;  de Frenne P.;  Lenoir J.;  Vangansbeke P.;  Verheyen K.;  Bernhardt-Römermann M.;  Baeten L.;  Hédl R.;  Berki I.;  Brunet J.;  van Calster H.;  Chudomelová M.;  Decocq G.;  Dirnböck T.;  Durak T.;  Heinken T.;  Jaroszewicz B.;  Kopecký M.;  Máliš F.;  Macek M.;  Malicki M.;  Naaf T.;  Nagel T.A.;  Ortmann-Ajkai A.;  Petřík P.;  Pielech R.;  Reczynska K.;  Schmidt W.;  Standovár T.;  Swierkosz K.;  Teleki B.;  Vild O.;  Wulf M.;  Coomes D.
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/28
biodiversity  canopy architecture  climate change  community response  disequilibrium  land use change  microclimate  plant community  understory  warming  Europe  forest  greenhouse effect  microclimate  physiology  tree  Europe  Forests  Global Warming  Microclimate  Trees  
Balancing volumetric and gravimetric uptake in highly porous materials for clean energy 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Chen Z.;  Li P.;  Anderson R.;  Wang X.;  Zhang X.;  Robison L.;  Redfern L.R.;  Moribe S.;  Islamoglu T.;  Gómez-Gualdrón D.A.;  Yildirim T.;  Stoddart J.F.;  Farha O.K.
收藏  |  浏览/下载:30/0  |  提交时间:2020/07/28
aluminum  hydrogen  iron  metal organic framework  methane  adsorption  gravimetry  organometallic compound  porous medium  volume  adsorption  alternative energy  Article  environmental temperature  gravimetry  porosity  pressure  priority journal  simulation  surface area  synthesis  United States  volumetry  
Ultrahigh thermal conductivity in isotope-enriched cubic boron nitride 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者:  Chen K.;  Song B.;  Ravichandran N.K.;  Zheng Q.;  Chen X.;  Lee H.;  Sun H.;  Li S.;  Gamage G.A.G.U.;  Tian F.;  Ding Z.;  Song Q.;  Rai A.;  Wu H.;  Koirala P.;  Schmidt A.J.;  Watanabe K.;  Lv B.;  Ren Z.;  Shi L.;  Cahill D.G.;  Taniguchi T.;  Broido D.;  Chen G.
收藏  |  浏览/下载:125/0  |  提交时间:2020/07/28
boron arsenide  boron derivative  boron phosphide  cubic boron nitride  isotope  unclassified drug  concentration (composition)  inorganic compound  temperature effect  thermal conductivity  Article  phonon  priority journal  thermal conductivity  ultrahigh thermal conductivity  
Very fast CRISPR on demand 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Liu Y.;  Zou R.S.;  He S.;  Nihongaki Y.;  Li X.;  Razavi S.;  Wu B.;  Ha T.
收藏  |  浏览/下载:20/0  |  提交时间:2020/07/28
Cas9 endonuclease Streptococcus pyogenes  double strand break repair protein MRE11  H2AX protein, human  histone  MRE11 protein, human  CRISPR Cas system  DNA cleavage  DNA repair  double stranded DNA break  fluorescence imaging  gene editing  genetics  HEK293 cell line  human  light  metabolism  phosphorylation  procedures  radiation response  single cell analysis  CRISPR-Associated Protein 9  CRISPR-Cas Systems  DNA Breaks, Double-Stranded  DNA Cleavage  DNA Repair  Gene Editing  HEK293 Cells  Histones  Humans  Light  MRE11 Homologue Protein  Optical Imaging  Phosphorylation  Single-Cell Analysis  
A noncanonical inhibitory circuit dampens behavioral sensitivity to light 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者:  Sonoda T.;  Li J.Y.;  Hayes N.W.;  Chan J.C.;  Okabe Y.;  Belin S.;  Nawabi H.;  Schmidt T.M.
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/28
4 aminobutyric acid  cre recombinase  glutamic acid  melanopsin  neurotransmitter  4 aminobutyric acid  4 aminobutyric acid receptor  glutamate decarboxylase  glutamate decarboxylase 2  melanopsin  scotopsin  brain  hormone  inhibition  light effect  nanotechnology  sensitivity analysis  Adeno associated virus  animal cell  Article  axon  brain region  GABAergic system  immunohistochemistry  lateral geniculate body  light  mouse  nonhuman  postsynaptic potential  priority journal  pupil reflex  retina ganglion cell  superior colliculus  suprachiasmatic nucleus  vision  wild type  animal  drug effect  female  light  male  metabolism  mutant mouse strain  nerve tract  physiology  radiation response  retina ganglion cell  vision  Mus  Animals  Female  GABAergic Neurons  gamma-Aminobutyric Acid  Glutamate Decarboxylase  Light  Male  Mice  Mice, Mutant Strains  Neural Pathways  Reflex, Pupillary  Retinal Ganglion Cells  Rod Opsins  Unconscious, Psychology  Visual Perception  
Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2) 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者:  Li R.;  Pei S.;  Chen B.;  Song Y.;  Zhang T.;  Yang W.;  Shaman J.
收藏  |  浏览/下载:26/0  |  提交时间:2020/07/28
disease prevalence  disease spread  disease transmission  infectious disease  metapopulation  population modeling  viral disease  virus  Article  Bayes theorem  China  conceptual framework  coronavirus disease 2019  data analysis  disease severity  disease transmission  documentation  human  mathematical model  metapopulation  nonhuman  priority journal  Severe acute respiratory syndrome coronavirus 2  travel  validation process  China  Coronavirus  SARS coronavirus  
One-dimensional van der Waals heterostructures 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者:  Xiang R.;  Inoue T.;  Zheng Y.;  Kumamoto A.;  Qian Y.;  Sato Y.;  Liu M.;  Tang D.;  Gokhale D.;  Guo J.;  Hisama K.;  Yotsumoto S.;  Ogamoto T.;  Arai H.;  Kobayashi Y.;  Zhang H.;  Hou B.;  Anisimov A.;  Maruyama M.;  Miyata Y.;  Okada S.;  Chiashi S.;  Li Y.;  Kong J.;  Kauppinen E.I.;  Ikuhara Y.;  Suenaga K.;  Maruyama S.
收藏  |  浏览/下载:132/0  |  提交时间:2020/07/28
boron nitride  inorganic salt  molybdenum disulfide  single walled nanotube  unclassified drug  chemical bonding  experimental study  nanotube  one-dimensional modeling  ultrastructure  Article  chemical structure  crystal  one dimensional van der Waals heterostructure  particle size  priority journal