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Computing cancer's weak spots 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Khamsi R.
收藏  |  浏览/下载：33/0  |  提交时间：2020/07/28
ruxolitinib  STAT3 protein  antineoplastic agent  transcription factor  algorithm  cancer  computer simulation  disease treatment  drug development  medicine  Article  cancer cell  cancer radiotherapy  enzyme inhibition  gene activity  gene expression regulation  gene interaction  gene mutation  gene repression  gene targeting  human  laboratory test  malignant neoplasm  molecular dynamics  nonhuman  oncologist  priority journal  RNA sequencing  algorithm  genetics  mutation  neoplasm  personalized medicine  procedures  systems biology  Algorithms  Antineoplastic Agents  Humans  Mutation  Neoplasms  Precision Medicine  Systems Biology  Transcription Factors  
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Zhou Z.;  He H.;  Wang K.;  Shi X.;  Wang Y.;  Su Y.;  Wang Y.;  Li D.;  Liu W.;  Zhang Y.;  Shen L.;  Han W.;  Shen L.;  Ding J.;  Shao F.
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/28
cell  cell component  cytology  enzyme  enzyme activity  gene expression  immunity  tumor  Mus  gamma interferon  granzyme  GSDMB protein, human  GZMA protein, human  pore forming cytotoxic protein  tumor protein  animal  Bagg albino mouse  chemistry  cytotoxic T lymphocyte  enzymology  genetics  HEK293 cell line  human  immunology  metabolism  mouse  natural killer cell  neoplasm  pathology  protein degradation  protein domain  pyroptosis  transgenic mouse  Animals  Granzymes  HEK293 Cells  Humans  Interferon-gamma  Killer Cells, Natural  Mice  Mice, Inbred BALB C  Mice, Transgenic  Neoplasm Proteins  Neoplasms  Pore Forming Cytotoxic Proteins  Protein Domains  Proteolysis  Pyroptosis  T-Lymphocytes, Cytotoxic  
The body's dangerous defenders 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Leslie M.
收藏  |  浏览/下载：32/0  |  提交时间：2020/07/28
alvelestat  avacopan  chemokine receptor CXCR2  danirixin  leukocyte elastase  n [2 (2,3 difluorobenzylthio) 6 (2,3 dihydroxy 1 methylpropoxy) 4 pyrimidinyl] 1 azetidinesulfonamide  nemiralisib  simvastatin  leukocyte elastase inhibitor  antimicrobial activity  apoptosis  cell  enzyme activity  physiological response  ANCA associated vasculitis  Article  autoimmune disease  autoimmunity  bacterial pneumonia  bactericidal activity  bronchiolitis obliterans  drug targeting  extracellular matrix  extracellular trap  hematopoietic stem cell transplantation  human  immunity  immunocompetent cell  infection  inflammation  lung disease  neutrophil  neutrophil chemotaxis  nonhuman  priority journal  risk factor  sepsis  single cell RNA seq  autoimmune disease  chronic obstructive lung disease  clinical trial (topic)  drug effect  enzymology  immunology  lung tumor  neutrophil  Autoimmune Diseases  Clinical Trials as Topic  Humans  Lung Neoplasms  Neutrophils  Proteinase Inhibitory Proteins, Secretory  Pulmonary Disease, Chronic Obstructive  
Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:  Ebright R.Y.;  Lee S.;  Wittner B.S.;  Niederhoffer K.L.;  Nicholson B.T.;  Bardia A.;  Truesdell S.;  Wiley D.F.;  Wesley B.;  Li S.;  Mai A.;  Aceto N.;  Vincent-Jordan N.;  Szabolcs A.;  Chirn B.;  Kreuzer J.;  Comaills V.;  Kalinich M.;  Haas W.;  Ting D.T.;  Toner M.;  Vasudevan S.;  Haber D.A.;  Maheswaran S.;  Micalizzi D.S.
收藏  |  浏览/下载：44/0  |  提交时间：2020/07/28
CRISPR associated protein  epidermal growth factor receptor 2  Ki 67 antigen  ribosome protein  ribosome RNA  transcription factor E2F  ribosome protein  cancer  cell  gene expression  genetic engineering  protein  RNA  tumor  animal experiment  animal model  animal tissue  Article  biogenesis  bioluminescence  breast cancer  cell cycle progression  cell cycle regulation  cell proliferation  circulating tumor cell  controlled study  enzyme activation  epithelial mesenchymal transition  gene expression profiling  genetic transcription  human  human cell  lung metastasis  metastasis  microfluidics  mouse  nonhuman  overall survival  phenotype  priority journal  progression free survival  promoter region  protein expression  protein processing  protein synthesis  proteomics  RNA sequence  transcription regulation  animal  breast tumor  cancer transplantation  CRISPR Cas system  female  gene expression regulation  genetics  pathology  sequence analysis  tumor cell line  tumor embolism  Mus  Animals  Breast Neoplasms  Cell Line, Tumor  CRISPR-Cas Systems  Female  Gene Expression Regulation, Neoplastic  Humans  Mice  Neoplasm Metastasis  Neoplasm Transplantation  Neoplastic Cells, Circulating  Ribosomal Proteins  Sequence Analysis, RNA  
Massively multiplex chemical transcriptomics at single-cell resolution 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者:  Srivatsan S.R.;  McFaline-Figueroa J.L.;  Ramani V.;  Saunders L.;  Cao J.;  Packer J.;  Pliner H.A.;  Jackson D.L.;  Daza R.M.;  Christiansen L.;  Zhang F.;  Steemers F.;  Shendure J.;  Trapnell C.
收藏  |  浏览/下载：13/0  |  提交时间：2020/07/28
4 (2 aminoethylamino) 1,8 dimethylimidazo[1,2 a]quinoxaline  abexinostat  acetic acid  belinostat  cudc 101  fimepinostat  givinostat  histone deacetylase inhibitor  m 344  n [2 [3 (1 piperazinylmethyl)imidazo[2,1 b]thiazol 6 yl]phenyl] 2 quinoxalinecarboxamide  panobinostat  pracinostat  rec 2282  trametinib  transcriptome  trichostatin A  unclassified drug  transcriptome  cancer  cell  chemical analysis  detection method  experimental study  genetic analysis  resolution  A-549 cell line  animal cell  animal experiment  Article  cell function  cell heterogeneity  cell labeling  cell proliferation  chromatin  controlled study  dose response  drug activity  experimentation  gene control  genetic transcription  human  human cell  K-562 cell line  MCF-7 cell line  mouse  nonhuman  pilot study  priority journal  proof of concept  RNA sequence  screening  single cell analysis  transcriptomics  cell nucleus  drug effect  genetics  genomics  high throughput screening  metabolism  neoplasm  procedures  single cell analysis  A549 Cells  Acetates  Cell Nucleus  Chromatin  Genomics  High-Throughput Screening Assays  Histone Deacetylase Inhibitors  Humans  K562 Cells  MCF-7 Cells  Neoplasms  RNA-Seq  Single-Cell Analysis  Transcriptome  
Regenerative potential of prostate luminal cells revealed by single-cell analysis 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者:  Karthaus W.R.;  Hofree M.;  Choi D.;  Linton E.L.;  Turkekul M.;  Bejnood A.;  Carver B.;  Gopalan A.;  Abida W.;  Laudone V.;  Biton M.;  Chaudhary O.;  Xu T.;  Masilionis I.;  Manova K.;  Mazutis L.;  Pe’er D.;  Regev A.;  Sawyers C.L.
收藏  |  浏览/下载：101/0  |  提交时间：2020/07/28
androgen  growth factor  Nrg2 growth factor  Rspo3 growth factor  unclassified drug  androgen binding protein  antiandrogen  ataxin 1  Atxn1 protein, mouse  glycosylphosphatidylinositol anchored protein  homeodomain protein  nerve growth factor  Nkx3-1 protein, mouse  Nrg2 protein, mouse  probasin  Psca protein, mouse  R-spondin3 protein, mouse  thrombospondin  transcription factor  tumor antigen  tumor protein  androgen  cancer  cell  gene expression  RNA  rodent  ablation therapy  animal cell  animal tissue  Article  cell differentiation  cell population  cell regeneration  cells by body anatomy  controlled study  gene  gene expression  human  luminal cell  male  mesenchyme cell  mouse  nonhuman  paracrine signaling  priority journal  prostate cell  prostate tissue  protein expression  Psca gene  RNA sequencing  Sca1 gene  single cell analysis  animal  genetics  mesenchymal stem cell  metabolism  organ size  organoid  physiology  prostate  prostate tumor  regeneration  sequence analysis  single cell analysis  Mus  Androgen Antagonists  Androgen-Binding Protein  Androgens  Animals  Antigens, Neoplasm  Ataxin-1  Cell Differentiation  Gene Expression  GPI-Linked Proteins  Homeodomain Proteins  Humans  Male  Mesenchymal Stem Cells  Mice  Neoplasm Proteins  Nerve Growth Factors  Organ Size  Organoids  Prostate  Prostatic Neoplasms  Regeneration  Sequence Analysis, RNA  Single-Cell Analysis  Thrombospondins  Transcription Factors  
The human tumor microbiome is composed of tumor type-specific intracellular bacteria 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Nejman D.;  Livyatan I.;  Fuks G.;  Gavert N.;  Zwang Y.;  Geller L.T.;  Rotter-Maskowitz A.;  Weiser R.;  Mallel G.;  Gigi E.;  Meltser A.;  Douglas G.M.;  Kamer I.;  Gopalakrishnan V.;  Dadosh T.;  Levin-Zaidman S.;  Avnet S.;  Atlan T.;  Cooper Z.A.;  Arora R.;  Cogdill A.P.;  Khan M.A.W.;  Ologun G.;  Bussi Y.;  Weinberger A.;  Lotan-Pompan M.;  Golani O.;  Perry G.;  Rokah M.;  Bahar-Shany K.;  Rozeman E.A.;  Blank C.U.;  Ronai A.;  Shaoul R.;  Amit A.;  Dorfman T.;  Kremer R.;  Cohen Z.R.;  Harnof S.;  Siegal T.;  Yehuda-Shnaidman E.;  Gal-Yam E.N.;  Shapira H.;  Baldini N.;  Langille M.G.I.;  Ben-Nun A.;  Kaufman B.;  Nissan A.;  Golan T.;  Dadiani M.;  Levanon K.;  Bar J.;  Yust S.;  Barshack I.;  Peeper D.S.;  Raz D.J.;  Segal E.;  Wargo J.A.;  Sandbank J.;  Shental N.;  Straussman R.
收藏  |  浏览/下载：31/0  |  提交时间：2020/07/28
bacterium  cell  microorganism  tumor  RNA 16S  bacterium  breast  classification  colon  female  genetics  human  immunotherapy  isolation and purification  lung  macrophage  male  microbiology  microflora  neoplasm  ovary  Bacteria  Breast  Colon  Female  Humans  Immunotherapy  Lung  Macrophages  Male  Microbiota  Neoplasms  Ovary  RNA, Ribosomal, 16S  
Partitioning of cancer therapeutics in nuclear condensates 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Klein I.A.;  Boija A.;  Afeyan L.K.;  Hawken S.W.;  Fan M.;  Dall'Agnese A.;  Oksuz O.;  Henninger J.E.;  Shrinivas K.;  Sabari B.R.;  Sagi I.;  Clark V.E.;  Platt J.M.;  Kar M.;  McCall P.M.;  Zamudio A.V.;  Manteiga J.C.;  Coffey E.L.;  Li C.H.;  Hannett N.M.;  Guo Y.E.;  Decker T.-M.;  Lee T.I.;  Zhang T.;  Weng J.-K.;  Taatjes D.J.;  Chakraborty A.;  Sharp P.A.;  Chang Y.T.;  Hyman A.A.;  Gray N.S.;  Young R.A.
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/28
cancer  condensate  disease  drug  physicochemical property  protein  tumor  antineoplastic agent  BRD4 protein, human  cell cycle protein  green fluorescent protein  heterochromatin-specific nonhistone chromosomal protein HP-1  MED1 protein, human  nonhistone protein  nuclear protein  nucleophosmin  peroxisome proliferator activated receptor binding protein  recombinant protein  serine arginine rich splicing factor  SRSF2 protein, human  transcription factor  cell nucleus  drug resistance  genetics  human  metabolism  neoplasm  Antineoplastic Agents  Cell Cycle Proteins  Cell Nucleus  Chromosomal Proteins, Non-Histone  Drug Resistance, Neoplasm  Green Fluorescent Proteins  Humans  Mediator Complex Subunit 1  Neoplasms  Nuclear Proteins  Recombinant Proteins  Serine-Arginine Splicing Factors  Transcription Factors