气候变化领域集成服务门户(CCPortal): The human tumor microbiome is composed of tumor type-specific intracellular bacteria

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DOI	10.1126/science.aay9189
	The human tumor microbiome is composed of tumor type-specific intracellular bacteria
	Nejman D.; Livyatan I.; Fuks G.; Gavert N.; Zwang Y.; Geller L.T.; Rotter-Maskowitz A.; Weiser R.; Mallel G.; Gigi E.; Meltser A.; Douglas G.M.; Kamer I.; Gopalakrishnan V.; Dadosh T.; Levin-Zaidman S.; Avnet S.; Atlan T.; Cooper Z.A.; Arora R.; Cogdill A.P.; Khan M.A.W.; Ologun G.; Bussi Y.; Weinberger A.; Lotan-Pompan M.; Golani O.; Perry G.; Rokah M.; Bahar-Shany K.; Rozeman E.A.; Blank C.U.; Ronai A.; Shaoul R.; Amit A.; Dorfman T.; Kremer R.; Cohen Z.R.; Harnof S.; Siegal T.; Yehuda-Shnaidman E.; Gal-Yam E.N.; Shapira H.; Baldini N.; Langille M.G.I.; Ben-Nun A.; Kaufman B.; Nissan A.; Golan T.; Dadiani M.; Levanon K.; Bar J.; Yust S.; Barshack I.; Peeper D.S.; Raz D.J.; Segal E.; Wargo J.A.; Sandbank J.; Shental N.; Straussman R.
发表日期	2020
ISSN	0036-8075
起始页码	973
结束页码	980
卷号	368 期号:6494
英文摘要	Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The intratumor bacteria are mostly intracellular and are present in both cancer and immune cells. We also noted correlations between intratumor bacteria or their predicted functions with tumor types and subtypes, patients' smoking status, and the response to immunotherapy. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	bacterium cell microorganism tumor RNA 16S bacterium breast classification colon female genetics human immunotherapy isolation and purification lung macrophage male microbiology microflora neoplasm ovary Bacteria Breast Colon Female Humans Immunotherapy Lung Macrophages Male Microbiota Neoplasms Ovary RNA, Ribosomal, 16S
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133466
推荐引用方式 GB/T 7714	Nejman D.,Livyatan I.,Fuks G.,et al. The human tumor microbiome is composed of tumor type-specific intracellular bacteria[J]. Science,2020,368(6494).
APA	Nejman D..,Livyatan I..,Fuks G..,Gavert N..,Zwang Y..,...&Straussman R..(2020).The human tumor microbiome is composed of tumor type-specific intracellular bacteria.,368(6494).
MLA	Nejman D.,et al."The human tumor microbiome is composed of tumor type-specific intracellular bacteria".368.6494(2020).