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Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol 期刊论文
Science, 2020, 卷号: 368, 期号: 6496
作者:  Zhang L.;  Zhao Y.;  Gao Y.;  Wu L.;  Gao R.;  Zhang Q.;  Wang Y.;  Wu C.;  Wu F.;  Gurcha S.S.;  Veerapen N.;  Batt S.M.;  Zhao W.;  Qin L.;  Yang X.;  Wang M.;  Zhu Y.;  Zhang B.;  Bi L.;  Zhang X.;  Yang H.;  Guddat L.W.;  Xu W.;  Wang Q.;  Li J.;  Besra G.S.;  Rao Z.
收藏  |  浏览/下载：16/0  |  提交时间：2022/01/14
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Dai W.;  Zhang B.;  Jiang X.-M.;  Su H.;  Li J.;  Zhao Y.;  Xie X.;  Jin Z.;  Peng J.;  Liu F.;  Li C.;  Li Y.;  Bai F.;  Wang H.;  Cheng X.;  Cen X.;  Hu S.;  Yang X.;  Wang J.;  Liu X.;  Xiao G.;  Jiang H.;  Rao Z.;  Zhang L.-K.;  Xu Y.;  Yang H.;  Liu H.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
aldehyde  antimicrobial activity  drug  enzyme activity  infectivity  inhibitor  reaction kinetics  viral disease  Coronavirus  SARS coronavirus  3C-like proteinase, Coronavirus  antivirus agent  cysteine proteinase  viral protein  animal  Betacoronavirus  chemical structure  chemistry  Chlorocebus aethiops  Coronavirus infection  dog  drug design  drug effect  enzyme active site  enzymology  female  human  male  mouse  pandemic  preclinical study  protein tertiary structure  Sprague Dawley rat  toxicity testing  Vero cell line  virus pneumonia  Animals  Antiviral Agents  Betacoronavirus  Catalytic Domain  Chlorocebus aethiops  Coronavirus Infections  Cysteine Endopeptidases  Dogs  Drug Design  Drug Evaluation, Preclinical  Female  Humans  Male  Mice  Molecular Structure  Pandemics  Pneumonia, Viral  Protein Structure, Tertiary  Rats, Sprague-Dawley  Toxicity Tests  Vero Cells  Viral Nonstructural Proteins  
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Zhang L.;  Zhao Y.;  Gao Y.;  Wu L.;  Gao R.;  Zhang Q.;  Wang Y.;  Wu C.;  Wu F.;  Gurcha S.S.;  Veerapen N.;  Batt S.M.;  Zhao W.;  Qin L.;  Yang X.;  Wang M.;  Zhu Y.;  Zhang B.;  Bi L.;  Zhang X.;  Yang H.;  Guddat L.W.;  Xu W.;  Wang Q.;  Li J.;  Besra G.S.;  Rao Z.
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/28
biochemistry  cell component  chemical binding  detection method  drug  drug resistance  enzyme  enzyme activity  inhibition  mutation  Mycobacterium tuberculosis  arabinosyltransferase  ethambutol  glycosyltransferase  tuberculostatic agent  cell wall  chemistry  cryoelectron microscopy  enzymology  multidrug resistance  Mycobacterium tuberculosis  protein conformation  Antitubercular Agents  Cell Wall  Cryoelectron Microscopy  Drug Resistance, Multiple, Bacterial  Ethambutol  Mycobacterium tuberculosis  Pentosyltransferases  Protein Conformation  
Peat brGDGTs-based Holocene temperature history of the Altai Mountains in arid Central Asia 期刊论文
Palaeogeography, Palaeoclimatology, Palaeoecology, 2020, 卷号: 538
作者:  Wu D.;  Cao J.;  Jia G.;  Guo H.;  Shi F.;  Zhang X.;  Rao Z.
收藏  |  浏览/下载：3/0  |  提交时间：2020/11/23
Complex “human−vegetation−climate” interactions in the Late Holocene and their significance for paleotemperature reconstructions 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2020, 卷号: 117, 期号: 11
作者:  Li Y.;  Tian Y.;  Guo H.;  Wei S.;  Cao J.;  Huang C.;  Shi F.;  Rao Z.
收藏  |  浏览/下载：2/0  |  提交时间：2021/01/06
Precipitation δ18O Recorded by the α-Cellulose δ18O of Plant Residues in Surface Soils: Evidence From a Broad Environmental Gradient in Inland China 期刊论文
Global Biogeochemical Cycles, 2019, 卷号: 33, 期号: 11
作者:  Shi F.;  Rao Z.;  Li Y.;  Cao J.;  Shi X.;  Li C.;  Sun W.
收藏  |  浏览/下载：1/0  |  提交时间：2020/06/19
Reconciling the ‘westerlies’ and ‘monsoon’ models: A new hypothesis for the Holocene moisture evolution of the Xinjiang region, NW China 期刊论文
Earth Science Reviews, 2019, 卷号: 191
作者:  Rao Z.;  Wu D.;  Shi F.;  Guo H.;  Cao J.;  Chen F.
收藏  |  浏览/下载：18/0  |  提交时间：2021/09/01
Holocene moisture history  Meltwater  Monsoon model  Temperature  Westerlies model  Xinjiang region  
Reconciling the ‘westerlies’ and ‘monsoon’ models: A new hypothesis for the Holocene moisture evolution of the Xinjiang region, NW China 期刊论文
EARTH-SCIENCE REVIEWS, 2019, 卷号: 191
作者:  Rao Z.;  Wu D.;  Shi F.;  Guo H.;  Cao J.;  Chen F.
收藏  |  浏览/下载：1/0  |  提交时间：2021/09/28
Is fish bone subfossil a good archive of heavy metal pollution on Nandao Island; South China Sea? 期刊论文
Marine Pollution Bulletin, 2019, 卷号: 143
作者:  Wang X.;  Sun J.;  Wu L.;  Xu L.;  Zhou Y.;  Rao Z.;  Jin J.;  Liu X.
收藏  |  浏览/下载：2/0  |  提交时间：2020/11/23