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Interplay of population size and environmental fluctuations: A new explanation for fitness cost rarity in asexuals 期刊论文
Ecology Letters, 2021, 卷号: 24, 期号: 9
作者:  Chavhan Y.;  Malusare S.;  Dey S.
收藏  |  浏览/下载:29/0  |  提交时间:2021/09/01
costs of adaptation  ecological specialisation  experimental evolution  fluctuating environments  maladaptation  mutation fixation  mutation supply  whole-genome whole-population sequencing  
Evolutionary analysis and lineage designation of SARS-CoV-2 genomes 期刊论文
Science Bulletin, 2021
作者:  Tang X.;  Ying R.;  Yao X.;  Li G.;  Wu C.;  Tang Y.;  Li Z.;  Kuang B.;  Wu F.;  Chi C.;  Du X.;  Qin Y.;  Gao S.;  Hu S.;  Ma J.;  Liu T.;  Pang X.;  Wang J.;  Zhao G.;  Tan W.;  Zhang Y.;  Lu X.;  Lu J.
收藏  |  浏览/下载:31/0  |  提交时间:2021/09/01
Adaptive evolution  Compensatory advantageous mutation  COVID-19  Evolutionary analysis  Lineage designation  
De novo genome assembly of a foxtail millet cultivar Huagu11 uncovered the genetic difference to the cultivar Yugu1, and the genetic mechanism of imazethapyr tolerance 期刊论文
BMC PLANT BIOLOGY, 2021, 卷号: 21, 期号: 1
作者:  Wang, Jie;  Li, Shiming;  Lan, Lei;  Xie, Mushan;  Cheng, Shu;  Gan, Xiaolong;  Huang, Gang;  Du, Guohua;  Yu, Kang;  Ni, Xuemei;  Liu, Baolong;  Peng, Guoxiong
收藏  |  浏览/下载:18/0  |  提交时间:2022/04/28
SETARIA-ITALICA  RESISTANCE  MODEL  INFERENCE  SEQUENCE  PROVIDES  PROGRAM  INSIGHTS  MUTATION  VIRIDIS  
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Wilmes S.;  Hafer M.;  Vuorio J.;  Tucker J.A.;  Winkelmann H.;  Löchte S.;  Stanly T.A.;  Pulgar Prieto K.D.;  Poojari C.;  Sharma V.;  Richter C.P.;  Kurre R.;  Hubbard S.R.;  Christopher Garcia K.;  Moraga I.;  Vattulainen I.;  Hitchcock I.S.;  Piehler J.
收藏  |  浏览/下载:38/0  |  提交时间:2020/07/28
cytokine receptor  homodimer  Janus kinase 2  ligand  oncoprotein  cancer  enzyme  enzyme activity  membrane  molecular analysis  mutation  protein  activation analysis  Article  cell membrane  computer model  controlled study  dimerization  fluorescence microscopy  gene mutation  HeLa cell line  molecular dynamics  mutant  oncogene  priority journal  protein domain  protein interaction  quantitative analysis  signal transduction  
Computing cancer's weak spots 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Khamsi R.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/28
ruxolitinib  STAT3 protein  antineoplastic agent  transcription factor  algorithm  cancer  computer simulation  disease treatment  drug development  medicine  Article  cancer cell  cancer radiotherapy  enzyme inhibition  gene activity  gene expression regulation  gene interaction  gene mutation  gene repression  gene targeting  human  laboratory test  malignant neoplasm  molecular dynamics  nonhuman  oncologist  priority journal  RNA sequencing  algorithm  genetics  mutation  neoplasm  personalized medicine  procedures  systems biology  Algorithms  Antineoplastic Agents  Humans  Mutation  Neoplasms  Precision Medicine  Systems Biology  Transcription Factors  
Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Guthrie L.M.;  Soma S.;  Yuan S.;  Silva A.;  Zulkifli M.;  Snavely T.C.;  Greene H.F.;  Nunez E.;  Lynch B.;  de Ville C.;  Shanbhag V.;  Lopez F.R.;  Acharya A.;  Petris M.J.;  Kim B.-E.;  Gohil V.M.;  Sacchettini J.C.
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/28
copper  copper zinc superoxide dismutase  cytochrome c oxidase  dopamine beta monooxygenase  elesclomol  monophenol monooxygenase  protein lysine 6 oxidase  copper  cytochrome c oxidase  elesclomol  hydrazine derivative  copper  cytochrome  enzyme  enzyme activity  mitochondrion  mortality  mutation  pathology  rodent  survival  animal cell  animal experiment  animal model  animal tissue  Article  cohort analysis  controlled study  disease severity  drug mechanism  Golgi complex  H9c2(2-1) cell line  in vivo study  male  Menkes syndrome  mitochondrial dynamics  mortality rate  mouse  nerve degeneration  nonhuman  priority journal  secretory pathway  survival rate  animal  brain  cell line  degenerative disease  disease model  drug effect  genetics  knockout mouse  Menkes syndrome  metabolism  mitochondrion  pathology  rat  transport at the cellular level  Murinae  Mus  Animals  Biological Transport  Brain  Cell Line  Copper  Copper Transporter 1  Disease Models, Animal  Electron Transport Complex IV  Hydrazines  Male  Menkes Kinky Hair Syndrome  Mice  Mice, Knockout  Mitochondria  Neurodegenerative Diseases  Rats  
PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:  Wang Q.;  Boshoff H.I.M.;  Harrison J.R.;  Ray P.C.;  Green S.R.;  Wyatt P.G.;  Barry Iii C.E.
收藏  |  浏览/下载:21/0  |  提交时间:2020/07/28
3,3 bis di(methylsulfonyl)propionamide  antiinfective agent  bacterial protein  glucose  glycerol  magnesium  phosphate  propionamide derivative  protein proline proline glutamate  protein proline proline glutamate 51  unclassified drug  amide  bacterial protein  lipid  phthiocerol dimycocerosate  propionamide  thiol derivative  cell component  chemical compound  membrane  mutation  protein  tuberculosis  antibiotic resistance  Article  bacterial cell  bacterial cell wall  bacterial growth  bacterial outer membrane  cell division  drug structure  Mycobacterium tuberculosis  nonhuman  nutrient uptake  priority journal  protein depletion  cell membrane  cell membrane permeability  chemistry  drug effect  gene deletion  genetics  metabolism  transport at the cellular level  Mycobacterium tuberculosis  Amides  Bacterial Proteins  Biological Transport  Cell Membrane  Cell Membrane Permeability  Drug Resistance, Bacterial  Gene Deletion  Glucose  Glycerol  Lipids  Mycobacterium tuberculosis  Sulfhydryl Compounds  
Polymerization in the actin ATPase clan regulates hexokinase activity in yeast 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:  Stoddard P.R.;  Lynch E.M.;  Farrell D.P.;  dosey A.M.;  diMaio F.;  Williams T.A.;  Kollman J.M.;  Murray A.W.;  Garner E.C.
收藏  |  浏览/下载:27/0  |  提交时间:2020/07/28
actin  adenosine triphosphatase  Glk1 protein  glucokinase  glucose  hexokinase  monomer  polymer  unclassified drug  carbohydrate  cell component  enzyme  enzyme activity  mutation  nutrient availability  polymer  polymerization  ultrastructure  actin filament  actin polymerization  Article  depolymerization  enzyme activity  enzyme inhibition  enzyme phosphorylation  nonhuman  nutrient availability  priority journal  protein blood level  Saccharomyces cerevisiae  Saccharomyces cerevisiae  
Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者:  Uckelmann H.J.;  Kim S.M.;  Wong E.M.;  Hatton C.;  Giovinazzo H.;  Gadrey J.Y.;  Krivtsov A.V.;  Rücker F.G.;  Döhner K.;  McGeehan G.M.;  Levine R.L.;  Bullinger L.;  Vassiliou G.S.;  Armstrong S.A.
收藏  |  浏览/下载:27/0  |  提交时间:2020/07/28
antileukemic agent  methionine  unclassified drug  vtp 50469  biological development  cancer  cell  disease treatment  mutation  numerical model  oral health  acute myeloid leukemia  animal cell  animal experiment  animal model  antineoplastic activity  Article  cell proliferation  cell self-renewal  chromatin  controlled study  drug targeting  gene  gene mutation  leukemia cell  molecularly targeted therapy  mouse  mouse model  nonhuman  NPM1 gene  preleukemia  priority journal  Mus  
Insights into human genetic variation and population history from 929 diverse genomes 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Bergström A.;  McCarthy S.A.;  Hui R.;  Almarri M.A.;  Ayub Q.;  Danecek P.;  Chen Y.;  Felkel S.;  Hallast P.;  Kamm J.;  Blanché H.;  Deleuze J.-F.;  Cann H.;  Mallick S.;  Reich D.;  Sandhu M.S.;  Skoglund P.;  Scally A.;  Xue Y.;  Durbin R.;  Tyler-Smith C.
收藏  |  浏览/下载:41/0  |  提交时间:2020/07/28
ecozone  effective population size  genetic variation  genome  geographical region  hunter-gatherer  Neanderthal  population size  Africa  article  genetic variation  Homo denisovan  human  hunter-gatherer  nonhuman  population size  ancestry group  animal  Asia  copy number variation  genetics  haplotype  hominid  Homo neanderthalensis  human genome  indel mutation  Pacific islands  phylogeny  population density  population genetics  single nucleotide polymorphism  Western Hemisphere  whole genome sequencing  Africa  Central America  North America  South America  Africa  Americas  Animals  Asia  Continental Population Groups  DNA Copy Number Variations  Genetic Variation  Genetics, Population  Genome, Human  Haplotypes  Hominidae  Humans  INDEL Mutation  Neanderthals  Oceania  Phylogeny  Polymorphism, Single Nucleotide  Population Density  Whole Genome Sequencing