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Paternal age negatively affects sperm production of the progeny 期刊论文
Ecology Letters, 2021, 卷号: 24, 期号: 4
作者:  Vuarin P.;  Lesobre L.;  Levêque G.;  Saint Jalme M.;  Lacroix F.;  Hingrat Y.;  Sorci G.
收藏  |  浏览/下载:32/0  |  提交时间:2021/09/01
Ageing  ejaculate quality  male gametes  offspring phenotype  paternal age  post-copulatory sexual selection  reproductive senescence  
Combining multiple tactics over time for cost-effective eradication of invading insect populations 期刊论文
Ecology Letters, 2021, 卷号: 24, 期号: 2
作者:  Lampert A.;  Liebhold A.M.
收藏  |  浏览/下载:31/0  |  提交时间:2021/09/01
Bioeconomic  extinction  gypsy moth  insecticide  invasion  management  mating disruption  model  optimisation  sterile male  
Absence of murine CFAP61 causes male infertility due to multiple morphological abnormalities of the flagella 期刊论文
Science Bulletin, 2020, 卷号: 65, 期号: 10
作者:  Huang T.;  Yin Y.;  Liu C.;  Li M.;  Yu X.;  Wang X.;  Zhang H.;  Muhammad T.;  Gao F.;  Li W.;  Chen Z.-J.;  Liu H.;  Ma J.
收藏  |  浏览/下载:26/0  |  提交时间:2021/09/01
Cfap61  Flagellum development  Male infertility  Multiple morphological abnormalities of the flagella (MMAF)  
Changes in contact patterns shape the dynamics of the COVID-19 outbreak in China 期刊论文
, 2020, 卷号: 368, 期号: 6498
作者:  Zhang J.;  Litvinova M.;  Liang Y.;  Wang Y.;  Wang W.;  Zhao S.;  Wu Q.;  Merler S.;  Viboud C.;  Vespignani A.;  Ajelli M.;  Yu H.
收藏  |  浏览/下载:23/0  |  提交时间:2020/07/28
adolescent  adult  age  aged  behavior  Betacoronavirus  child  China  communicable disease control  contact examination  Coronavirus infection  disease predisposition  epidemic  female  human  infant  male  middle aged  pandemic  preschool child  school  theoretical model  virus pneumonia  workplace  young adult  Adolescent  Adult  Age Factors  Aged  Behavior  Betacoronavirus  Child  Child, Preschool  China  Communicable Disease Control  Contact Tracing  Coronavirus Infections  Disease Outbreaks  Disease Susceptibility  Female  Humans  Infant  Male  Middle Aged  Models, Theoretical  Pandemics  Pneumonia, Viral  Schools  Workplace  Young Adult  
Does socioeconomic status moderate the political divide on climate change? The roles of education, income, and individualism 期刊论文
Global Environmental Change, 2020, 卷号: 60
作者:  Ballew M.T.;  Pearson A.R.;  Goldberg M.H.;  Rosenthal S.A.;  Leiserowitz A.
收藏  |  浏览/下载:17/0  |  提交时间:2021/09/01
Climate change  Conservative white male effect  Education  Income  Individualism  Polarization  
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Dai W.;  Zhang B.;  Jiang X.-M.;  Su H.;  Li J.;  Zhao Y.;  Xie X.;  Jin Z.;  Peng J.;  Liu F.;  Li C.;  Li Y.;  Bai F.;  Wang H.;  Cheng X.;  Cen X.;  Hu S.;  Yang X.;  Wang J.;  Liu X.;  Xiao G.;  Jiang H.;  Rao Z.;  Zhang L.-K.;  Xu Y.;  Yang H.;  Liu H.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/28
aldehyde  antimicrobial activity  drug  enzyme activity  infectivity  inhibitor  reaction kinetics  viral disease  Coronavirus  SARS coronavirus  3C-like proteinase, Coronavirus  antivirus agent  cysteine proteinase  viral protein  animal  Betacoronavirus  chemical structure  chemistry  Chlorocebus aethiops  Coronavirus infection  dog  drug design  drug effect  enzyme active site  enzymology  female  human  male  mouse  pandemic  preclinical study  protein tertiary structure  Sprague Dawley rat  toxicity testing  Vero cell line  virus pneumonia  Animals  Antiviral Agents  Betacoronavirus  Catalytic Domain  Chlorocebus aethiops  Coronavirus Infections  Cysteine Endopeptidases  Dogs  Drug Design  Drug Evaluation, Preclinical  Female  Humans  Male  Mice  Molecular Structure  Pandemics  Pneumonia, Viral  Protein Structure, Tertiary  Rats, Sprague-Dawley  Toxicity Tests  Vero Cells  Viral Nonstructural Proteins  
T cells with dysfunctional mitochondria induce multimorbidity and premature senescence 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Desdín-Micó G.;  Soto-Heredero G.;  Aranda J.F.;  Oller J.;  Carrasco E.;  Gabandé-Rodríguez E.;  Blanco E.M.;  Alfranca A.;  Cussó L.;  Desco M.;  Ibañez B.;  Gortazar A.R.;  Fernández-Marcos P.;  Navarro M.N.;  Hernaez B.;  Alcamí A.;  Baixauli F.;  Mittelbrunn M.
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/28
cardiovascular disease  enzyme activity  gene expression  metabolism  mitochondrial DNA  morbidity  senescence  tumor  Mus  DNA binding protein  mitochondrial protein  mitochondrial transcription factor A  nicotinamide adenine dinucleotide  transcription factor  tumor necrosis factor  animal  cytokine release syndrome  female  fitness  gene deletion  genetics  immunology  inflammation  longevity  male  metabolism  mitochondrion  mouse  multiple chronic conditions  mutant mouse strain  premature aging  T lymphocyte  ultrastructure  Aging, Premature  Animals  Cytokine Release Syndrome  DNA-Binding Proteins  Female  Gene Deletion  Inflammation  Longevity  Male  Mice  Mice, Mutant Strains  Mitochondria  Mitochondrial Proteins  Multimorbidity  NAD  Physical Fitness  T-Lymphocytes  Transcription Factors  Tumor Necrosis Factor-alpha  
Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Guthrie L.M.;  Soma S.;  Yuan S.;  Silva A.;  Zulkifli M.;  Snavely T.C.;  Greene H.F.;  Nunez E.;  Lynch B.;  de Ville C.;  Shanbhag V.;  Lopez F.R.;  Acharya A.;  Petris M.J.;  Kim B.-E.;  Gohil V.M.;  Sacchettini J.C.
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/28
copper  copper zinc superoxide dismutase  cytochrome c oxidase  dopamine beta monooxygenase  elesclomol  monophenol monooxygenase  protein lysine 6 oxidase  copper  cytochrome c oxidase  elesclomol  hydrazine derivative  copper  cytochrome  enzyme  enzyme activity  mitochondrion  mortality  mutation  pathology  rodent  survival  animal cell  animal experiment  animal model  animal tissue  Article  cohort analysis  controlled study  disease severity  drug mechanism  Golgi complex  H9c2(2-1) cell line  in vivo study  male  Menkes syndrome  mitochondrial dynamics  mortality rate  mouse  nerve degeneration  nonhuman  priority journal  secretory pathway  survival rate  animal  brain  cell line  degenerative disease  disease model  drug effect  genetics  knockout mouse  Menkes syndrome  metabolism  mitochondrion  pathology  rat  transport at the cellular level  Murinae  Mus  Animals  Biological Transport  Brain  Cell Line  Copper  Copper Transporter 1  Disease Models, Animal  Electron Transport Complex IV  Hydrazines  Male  Menkes Kinky Hair Syndrome  Mice  Mice, Knockout  Mitochondria  Neurodegenerative Diseases  Rats  
Widespread receptor-driven modulation in peripheral olfactory coding 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:  Xu L.;  Li W.;  Voleti V.;  Zou D.-J.;  Hillman E.M.C.;  Firestein S.
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/28
antagonism  cell component  detection method  odor  olfaction  protein  animal cell  animal experiment  article  excitation  high throughput analysis  male  microscopy  mouse  nonhuman  odor  olfactory epithelium  olfactory receptor neuron  animal  confocal microscopy  innervation  mutant mouse strain  olfactory mucosa  physiology  single cell analysis  acetophenone  acetophenone derivative  benzyl acetate  benzyl derivative  citral  fragrance  Acetophenones  Acyclic Monoterpenes  Animals  Benzyl Compounds  Mice  Mice, Mutant Strains  Microscopy, Confocal  Odorants  Olfactory Mucosa  Olfactory Receptor Neurons  Single-Cell Analysis  Smell  
Transcription factor AP2 controls cnidarian germ cell induction 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  DuBuc T.Q.;  Schnitzler C.E.;  Chrysostomou E.;  McMahon E.T.;  Febrimarsa;  Gahan J.M.;  Buggie T.;  Gornik S.G.;  Hanley S.;  Barreira S.N.;  Gonzalez P.;  Baxevanis A.D.;  Frank U.
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/28
transcription factor  transcription factor AP2  unclassified drug  clonal organism  gene expression  germ cell  invertebrate  physiological response  protein  adult  Article  cell fate  Cnidaria  embryo  female  genotype  germ cell  gonad development  Hydractinia symbiolongicarpus  male  nonhuman  phenotype  priority journal  protein expression  wild type  Animalia  Bilateria  Hydractinia symbiolongicarpus  Mammalia