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| DOI | 10.1126/science.aay6782 |
| Transcription factor AP2 controls cnidarian germ cell induction | |
| DuBuc T.Q.; Schnitzler C.E.; Chrysostomou E.; McMahon E.T.; Febrimarsa; Gahan J.M.; Buggie T.; Gornik S.G.; Hanley S.; Barreira S.N.; Gonzalez P.; Baxevanis A.D.; Frank U. | |
| 发表日期 | 2020 |
| ISSN | 0036-8075 |
| 起始页码 | 757 |
| 结束页码 | 762 |
| 卷号 | 367期号:6479 |
| 英文摘要 | Clonal animals do not sequester a germ line during embryogenesis. Instead, they have adult stem cells that contribute to somatic tissues or gametes. How germ fate is induced in these animals, and whether this process is related to bilaterian embryonic germline induction, is unknown. We show that transcription factor AP2 (Tfap2), a regulator of mammalian germ lines, acts to commit adult stem cells, known as i-cells, to the germ cell fate in the clonal cnidarian Hydractinia symbiolongicarpus. Tfap2 mutants lacked germ cells and gonads. Transplanted wild-type cells rescued gonad development but not germ cell induction in Tfap2 mutants. Forced expression of Tfap2 in i-cells converted them to germ cells. Therefore, Tfap2 is a regulator of germ cell commitment across germ line–sequestering and germ line–nonsequestering animals. © 2020 American Association for the Advancement of Science. All rights reserved. |
| 关键词 | transcription factortranscription factor AP2unclassified drugclonal organismgene expressiongerm cellinvertebratephysiological responseproteinadultArticlecell fateCnidariaembryofemalegenotypegerm cellgonad developmentHydractinia symbiolongicarpusmalenonhumanphenotypepriority journalprotein expressionwild typeAnimaliaBilateriaHydractinia symbiolongicarpusMammalia |
| 语种 | 英语 |
| 来源机构 | Science |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/133716 |
| 推荐引用方式 GB/T 7714 | DuBuc T.Q.,Schnitzler C.E.,Chrysostomou E.,et al. Transcription factor AP2 controls cnidarian germ cell induction[J]. Science,2020,367(6479). |
| APA | DuBuc T.Q..,Schnitzler C.E..,Chrysostomou E..,McMahon E.T..,Febrimarsa.,...&Frank U..(2020).Transcription factor AP2 controls cnidarian germ cell induction.,367(6479). |
| MLA | DuBuc T.Q.,et al."Transcription factor AP2 controls cnidarian germ cell induction".367.6479(2020). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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