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Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载：51/0  |  提交时间：2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir 期刊论文
, 2020, 卷号: 368, 期号: 6498
作者:  Yin W.;  Mao C.;  Luan X.;  Shen D.-D.;  Shen Q.;  Su H.;  Wang X.;  Zhou F.;  Zhao W.;  Gao M.;  Chang S.;  Xie Y.-C.;  Tian G.;  Jiang H.-W.;  Tao S.-C.;  Shen J.;  Jiang Y.;  Jiang H.;  Xu Y.;  Zhang S.;  Zhang Y.;  Xu H.E.
收藏  |  浏览/下载：204/0  |  提交时间：2020/07/28
adenosine phosphate  alanine  antivirus agent  enzyme inhibitor  multiprotein complex  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  virus RNA  Betacoronavirus  chemistry  cryoelectron microscopy  drug effect  enzyme active site  enzymology  metabolism  molecular model  physiology  protein conformation  virus replication  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Enzyme Inhibitors  Models, Molecular  Multiprotein Complexes  Protein Conformation  RNA Replicase  RNA, Viral  Viral Nonstructural Proteins  Virus Replication  
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Pareek V.;  Tian H.;  Winograd N.;  Benkovic S.J.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
adenosine phosphate  guanosine phosphate  multienzyme complex  nucleotide  purine  purine  purine derivative  cell  experimental study  imaging method  mass spectrometry  metabolism  protein  Article  biochemistry  enzyme assay  gas cluster ion beam secondary ion mass spectrometry  image analysis  mass spectrometry  metabolomics  mitochondrion  molecular imaging  molecular probe  priority journal  purine synthesis  reaction analysis  single cell analysis  biosynthesis  fluorescence imaging  HeLa cell line  human  metabolism  metabolomics  procedures  secondary ion mass spectrometry  HeLa Cells  Humans  Metabolomics  Mitochondria  Multienzyme Complexes  Optical Imaging  Purines  Single-Cell Analysis  Spectrometry, Mass, Secondary Ion  
Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Nagashima S.;  Tábara L.-C.;  Tilokani L.;  Paupe V.;  Anand H.;  Pogson J.H.;  Zunino R.;  McBride H.M.;  Prudent J.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
adenosine diphosphate ribosylation factor 1  dynamin related protein 1  mitochondrial protein  phosphatidylinositol 4 kinase IIIbeta  phosphatidylinositol 4 phosphate  phosphatidylinositol kinase  unclassified drug  adenosine diphosphate ribosylation factor 1  ARF1 protein, human  DNM1L protein, human  dynamin  phosphatidylinositol 4-phosphate  phosphatidylinositol kinase  polyphosphoinositide  cell component  cell organelle  chemical compound  enzyme  enzyme activity  mitochondrion  protein  Article  controlled study  COS-7 cell line  endoplasmic reticulum  fibroblast  gene silencing  HeLa cell line  human  human cell  membrane microdomain  mitochondrial division  mitochondrial dynamics  mitochondrial scission  priority journal  protein localization  trans Golgi network  U2OS cell line  animal  cell line  Chlorocebus aethiops  CV-1 cell line  genetics  metabolism  mitochondrial membrane  mitochondrion  RNA interference  trans Golgi network  ultrastructure  Mammalia  1-Phosphatidylinositol 4-Kinase  ADP-Ribosylation Factor 1  Animals  Cell Line  Chlorocebus aethiops  COS Cells  Dynamins  Endoplasmic Reticulum  HeLa Cells  Humans  Membrane Microdomains  Mitochondria  Mitochondrial Dynamics  Mitochondrial Membranes  Phosphatidylinositol Phosphates  RNA Interference  trans-Golgi Network  
An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Zhao P.;  Sun X.;  Chaggan C.;  Liao Z.;  Wong K.I.;  He F.;  Singh S.;  Loomba R.;  Karin M.;  Witztum J.L.;  Saltiel A.R.
收藏  |  浏览/下载：54/0  |  提交时间：2020/07/28
6,7 dihydro 4 hydroxy 3 (2' hydroxy 1,1' biphenyl 4 yl) 6 oxothieno[2,3 b]pyridine 5 carbonitrile  adenosine phosphate  caspase 3  caspase 6  caspase 7  cytochrome c  hydroxymethylglutaryl coenzyme A reductase kinase  matrix metalloproteinase  apoptosis  cytochrome  enzyme  enzyme activity  inhibition  protein  rodent  AMPK signaling  animal experiment  animal model  animal tissue  apoptosis  Article  C57BL 6 mouse  cell death  controlled study  drug mechanism  enzyme activation  enzyme activity  enzyme inhibition  enzyme phosphorylation  enzyme repression  gene knockout  human  human cell  human tissue  liver cell  liver fibrosis  liver injury  male  mouse  nonalcoholic steatohepatitis  nonhuman  priority journal  protein cleavage  protein secretion