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The ER membrane protein complex subunit Emc3 controls angiogenesis via the FZD4/WNT signaling axis 期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2021, 卷号: 64, 期号: 11
作者:  Yang, Mu;  Li, Shujin;  Liu, Wenjing;  Li, Xiao;  He, Yunqi;  Yang, Yeming;  Sun, Kuanxiang;  Zhang, Lin;  Tian, Wanli;  Duan, Lixin;  Chen, Huafu;  Yao, Dezhong;  Yang, Zhenglin;  Zhu, Xianjun
收藏  |  浏览/下载：41/0  |  提交时间：2022/04/28
RETINAL VASCULAR DEVELOPMENT  BETA-CATENIN  ZIKA VIRUS  WNT  NORRIN  VARIANT  IDENTIFICATION  FRIZZLED-4  RECEPTORS  TSPAN12  
Structure and immunomodulatory activity of a water-soluble alpha-glucan from Hirsutella sinensis mycelia 期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 卷号: 189
作者:  Rong, Lin;  Li, Guoqiang;  Zhang, Yuxia;  Xiao, Yuancan;  Qiao, Yajun;  Yang, Mengmeng;  Wei, Lixin;  Bi, Hongtao;  Gao, Tingting
收藏  |  浏览/下载：47/0  |  提交时间：2022/04/28
PATTERN-RECOGNITION RECEPTORS  NF-KAPPA-B  IMMUNOSTIMULATORY ACTIVITY  ANTIOXIDANT ACTIVITY  CORDYCEPS-SINENSIS  POLYSACCHARIDE  ACTIVATION  ANAMORPH  PHAGOCYTOSIS  ELUCIDATION  
TLR2 inhibition ameliorates the amplification effect of LPS on lipid accumulation and lipotoxicity in hepatic cells 期刊论文
ANNALS OF TRANSLATIONAL MEDICINE, 2021, 卷号: 9, 期号: 18
作者:  Zhang, Liting;  Xie, Zehui;  Yu, Hongmiao;  Du, Haoxuan;  Wang, Xuqiao;  Cai, Jiazheng;  Qiu, Yingfei;  Chen, Rui;  Jiang, Xiaofeng;  Liu, Zelin;  Li, Yi;  Chen, Tuo
收藏  |  浏览/下载：34/0  |  提交时间：2022/04/28
FATTY LIVER-DISEASE  NONALCOHOLIC STEATOHEPATITIS  ADVANCED FIBROSIS  LIPOPOLYSACCHARIDE  RECEPTORS  AXIS  ACID  
Stanley Cohen (1922-2020) 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Carpenter G.;  Coffey R.
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/28
epidermal growth factor  epidermal growth factor receptor  nerve growth factor  art  awards and prizes  biochemistry  history  isolation and purification  metabolism  United States  Biochemistry  Epidermal Growth Factor  ErbB Receptors  History, 20th Century  History, 21st Century  Nerve Growth Factor  Nobel Prize  United States  
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Yuan M.;  Wu N.C.;  Zhu X.;  Lee C.-C.D.;  So R.T.Y.;  Lv H.;  Mok C.K.P.;  Wilson I.A.
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  epitope  neutralizing antibody  virus hemagglutinin  virus spike protein  angiotensin converting enzyme 2  coronavirus receptors  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  neutralizing antibody  spike glycoprotein, SARS-CoV  spike protein, SARS-CoV-2  virus antibody  virus antigen  virus receptor  antibody  antigen  chemical binding  crystal structure  protein  respiratory disease  viral disease  virus  amino terminal sequence  antibody isolation  antigen binding  antigenicity  Article  binding affinity  binding site  conservation biology  controlled study  coronavirus disease 2019  cross reaction  cryoelectron microscopy  crystal structure  enzyme linked immunosorbent assay  epidemic  glycosylation  human  hydrophobicity  immune response  in vitro study  in vivo study  light chain  nonhuman  priority journal  protein conformation  protein domain  protein interaction  protein localization  protein structure  protein targeting  receptor binding  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  amino acid sequence  antibody affinity  Betacoronavirus  binding site  chemistry  immunology  metabolism  molecular model  SARS coronavirus  X ray crystallography  Coronavirus  SARS coronavirus  Amino Acid Sequence  Antibodies, Neutralizing  Antibodies, Viral  Antibody Affinity  Antigens, Viral  Betacoronavirus  Binding Sites  Cross Reactions  Crystallography, X-Ray  Epitopes  Models, Molecular  Peptidyl-Dipeptidase A  Protein Conformation  Protein Domains  Protein Interaction Domains and Motifs  Receptors, Virus  SARS Virus  Spike Glycoprotein, Coronavirus  
Structural basis of Gs and Gi recognition by the human glucagon receptor 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Qiao A.;  Han S.;  Li X.;  Li Z.;  Zhao P.;  Dai A.;  Chang R.;  Tai L.;  Tan Q.;  Chu X.;  Ma L.;  Thorsen T.S.;  Reedtz-Runge S.;  Yang D.;  Wang M.-W.;  Sexton P.M.;  Wootten D.;  Sun F.;  Zhao Q.;  Wu B.
收藏  |  浏览/下载：44/0  |  提交时间：2020/07/28
cyclic AMP  glucagon  glucagon receptor  inhibitory guanine nucleotide binding protein  stimulatory guanine nucleotide binding protein  glucagon receptor  inhibitory guanine nucleotide binding protein  protein binding  stimulatory guanine nucleotide binding protein  chemical binding  enzyme activity  gene expression  mutagenicity  protein  alpha helix  Article  binding affinity  carboxy terminal sequence  conformational transition  cryoelectron microscopy  human  molecular recognition  mutagenesis  priority journal  protein binding  protein function  protein protein interaction  protein structure  signal transduction  binding site  chemistry  metabolism  molecular model  protein conformation  ultrastructure  Binding Sites  Cryoelectron Microscopy  Glucagon  GTP-Binding Protein alpha Subunits, Gi-Go  GTP-Binding Protein alpha Subunits, Gs  Humans  Models, Molecular  Protein Binding  Protein Conformation  Protein Conformation, alpha-Helical  Receptors, Glucagon  Signal Transduction  
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  ElTanbouly M.A.;  Zhao Y.;  Nowak E.;  Li J.;  Schaafsma E.;  Le Mercier I.;  Ceeraz S.;  Lines J.L.;  Peng C.;  Carriere C.;  Huang X.;  Day M.;  Koehn B.;  Lee S.W.;  Morales M.S.;  Hogquist K.A.;  Jameson S.C.;  Mueller D.;  Rothstein J.;  Blazar B.R.;  Cheng C.;  Noelle R.J.
收藏  |  浏览/下载：57/0  |  提交时间：2020/07/28
cell protein  interferon  kruppel like factor 2  T lymphocyte receptor  unclassified drug  V type immunoglobulin domain containing suppressor of T cell activation protein  B7 antigen  Dies1 protein, mouse  lymphocyte antigen receptor  membrane protein  monoclonal antibody  VSIR protein, human  biological development  cell  gene expression  heterogeneity  homeostasis  immune response  immunity  tolerance  acute graft versus host disease  animal cell  animal experiment  animal model  Article  CD4+ T lymphocyte  cell death  cell expansion  cell fate  cell heterogeneity  cell loss  cell survival  controlled study  female  gene  gene deletion  homeostasis  immunological tolerance  in vivo study  long term survival  male  mouse  nonhuman  phenotype  priority journal  protein expression  protein function  rheumatoid arthritis  RNA sequencing  systemic lupus erythematosus  T lymphocyte  T lymphocyte activation  T lymphocyte subpopulation  TCR gene  upregulation  VISTA gene  animal  C57BL mouse  genetics  immunological tolerance  immunology  knockout mouse  lymphocyte activation  physiology  T lymphocyte  Mus  Animals  Antibodies, Monoclonal  B7 Antigens  Lymphocyte Activation  Membrane Proteins  Mice  Mice, Inbred C57BL  Mice, Knockout  Peripheral Tolerance  Receptors, Antigen, T-Cell  T-Lymphocytes  
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Wu Y.;  Wang F.;  Shen C.;  Peng W.;  Li D.;  Zhao C.;  Li Z.;  Li S.;  Bi Y.;  Yang Y.;  Gong Y.;  Xiao H.;  Fan Z.;  Tan S.;  Wu G.;  Tan W.;  Lu X.;  Fan C.;  Wang Q.;  Liu Y.;  Zhang C.;  Qi J.;  Gao G.F.;  Gao F.;  Liu L.
收藏  |  浏览/下载：42/0  |  提交时间：2020/07/28
Coronavirus  angiotensin converting enzyme 2  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  monoclonal antibody  neutralizing antibody  virus antibody  virus receptor  animal  chemistry  Coronavirus infection  disease model  human  immunology  isolation and purification  lung  mouse  pandemic  protein domain  serodiagnosis  virology  virus load  virus pneumonia  Animals  Antibodies, Monoclonal  Antibodies, Neutralizing  Antibodies, Viral  Coronavirus Infections  Disease Models, Animal  Humans  Immunodominant Epitopes  Lung  Mice  Neutralization Tests  Pandemics  Peptidyl-Dipeptidase A  Pneumonia, Viral  Protein Domains  Receptors, Virus  Spike Glycoprotein, Coronavirus  Viral Load  
SARS-CoV-2 productively infects human gut enterocytes 期刊论文
, 2020, 卷号: 369, 期号: 6499
作者:  Lamers M.M.;  Beumer J.;  van der Vaart J.;  Knoops K.;  Puschhof J.;  Breugem T.I.;  Ravelli R.B.G.;  Paul van Schayck J.;  Mykytyn A.Z.;  Duimel H.Q.;  van Donselaar E.;  Riesebosch S.;  Kuijpers H.J.H.;  Schipper D.;  van de Wetering W.J.;  de Graaf M.;  Koopmans M.;  Cuppen E.;  Peters P.J.;  Haagmans B.L.;  Clevers H.
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  dipeptidyl carboxypeptidase  messenger RNA  virus receptor  Betacoronavirus  cell culture technique  cell differentiation  cell lineage  cell proliferation  culture medium  gene expression  genetics  human  ileum  intestine cell  lung  male  metabolism  organoid  physiology  respiratory mucosa  SARS coronavirus  ultrastructure  virology  virus replication  Betacoronavirus  Cell Culture Techniques  Cell Differentiation  Cell Lineage  Cell Proliferation  Culture Media  Enterocytes  Gene Expression  Humans  Ileum  Lung  Male  Organoids  Peptidyl-Dipeptidase A  Receptors, Virus  Respiratory Mucosa  RNA, Messenger  SARS Virus  Virus Replication  
Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Yu J.;  Gimenez L.E.;  Hernandez C.C.;  Wu Y.;  Wein A.H.;  Han G.W.;  McClary K.;  Mittal S.R.;  Burdsall K.;  Stauch B.;  Wu L.;  Stevens S.N.;  Peisley A.;  Williams S.Y.;  Chen V.;  Millhauser G.L.;  Zhao S.;  Cone R.D.;  Stevens R.C.
收藏  |  浏览/下载：40/0  |  提交时间：2020/07/28
alpha intermedin  calcium ion  cyclic AMP  G protein coupled receptor  heterotrimeric guanine nucleotide binding protein  inwardly rectifying potassium channel  inwardly rectifying potassium channel subunit Kir7.1  melanocortin 4 receptor  n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide]  unclassified drug  calcium  G protein coupled receptor  intermedin  inwardly rectifying potassium channel  Kir7.1 channel  ligand  melanocortin 4 receptor  n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide]  protein binding  calcium  chemical binding  homeostasis  hormone  ligand  obesity  peptide  protein  Article  binding affinity  complex formation  crystallization  drug structure  extracellular calcium  human  ligand binding  priority journal  protein structure  receptor blocking  signal transduction  chemistry  genetics  mutation  protein multimerization  protein secondary structure  X ray crystallography  Calcium  Crystallography, X-Ray  Cyclic AMP  Humans  Ligands  Melanocyte-Stimulating Hormones  Mutation  Potassium Channels, Inwardly Rectifying  Protein Binding  Protein Multimerization  Protein Structure, Secondary  Receptor, Melanocortin, Type 4  Receptors, G-Protein-Coupled  Signal Transduction