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期刊论文 [27]
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Interplay of population size and environmental fluctuations: A new explanation for fitness cost rarity in asexuals
期刊论文
Ecology Letters, 2021, 卷号: 24, 期号: 9
作者:
Chavhan Y.
;
Malusare S.
;
Dey S.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2021/09/01
costs of adaptation
ecological specialisation
experimental evolution
fluctuating environments
maladaptation
mutation fixation
mutation supply
whole-genome whole-population sequencing
Evolutionary analysis and lineage designation of SARS-CoV-2 genomes
期刊论文
Science Bulletin, 2021
作者:
Tang X.
;
Ying R.
;
Yao X.
;
Li G.
;
Wu C.
;
Tang Y.
;
Li Z.
;
Kuang B.
;
Wu F.
;
Chi C.
;
Du X.
;
Qin Y.
;
Gao S.
;
Hu S.
;
Ma J.
;
Liu T.
;
Pang X.
;
Wang J.
;
Zhao G.
;
Tan W.
;
Zhang Y.
;
Lu X.
;
Lu J.
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/09/01
Adaptive evolution
Compensatory advantageous mutation
COVID-19
Evolutionary analysis
Lineage designation
De novo genome assembly of a foxtail millet cultivar Huagu11 uncovered the genetic difference to the cultivar Yugu1, and the genetic mechanism of imazethapyr tolerance
期刊论文
BMC PLANT BIOLOGY, 2021, 卷号: 21, 期号: 1
作者:
Wang, Jie
;
Li, Shiming
;
Lan, Lei
;
Xie, Mushan
;
Cheng, Shu
;
Gan, Xiaolong
;
Huang, Gang
;
Du, Guohua
;
Yu, Kang
;
Ni, Xuemei
;
Liu, Baolong
;
Peng, Guoxiong
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/04/28
SETARIA-ITALICA
RESISTANCE
MODEL
INFERENCE
SEQUENCE
PROVIDES
PROGRAM
INSIGHTS
MUTATION
VIRIDIS
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations
期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:
Wilmes S.
;
Hafer M.
;
Vuorio J.
;
Tucker J.A.
;
Winkelmann H.
;
Löchte S.
;
Stanly T.A.
;
Pulgar Prieto K.D.
;
Poojari C.
;
Sharma V.
;
Richter C.P.
;
Kurre R.
;
Hubbard S.R.
;
Christopher Garcia K.
;
Moraga I.
;
Vattulainen I.
;
Hitchcock I.S.
;
Piehler J.
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2020/07/28
cytokine receptor
homodimer
Janus kinase 2
ligand
oncoprotein
cancer
enzyme
enzyme activity
membrane
molecular analysis
mutation
protein
activation analysis
Article
cell membrane
computer model
controlled study
dimerization
fluorescence microscopy
gene mutation
HeLa cell line
molecular dynamics
mutant
oncogene
priority journal
protein domain
protein interaction
quantitative analysis
signal transduction
Computing cancer's weak spots
期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:
Khamsi R.
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2020/07/28
ruxolitinib
STAT3 protein
antineoplastic agent
transcription factor
algorithm
cancer
computer simulation
disease treatment
drug development
medicine
Article
cancer cell
cancer radiotherapy
enzyme inhibition
gene activity
gene expression regulation
gene interaction
gene mutation
gene repression
gene targeting
human
laboratory test
malignant neoplasm
molecular dynamics
nonhuman
oncologist
priority journal
RNA sequencing
algorithm
genetics
mutation
neoplasm
personalized medicine
procedures
systems biology
Algorithms
Antineoplastic Agents
Humans
Mutation
Neoplasms
Precision Medicine
Systems Biology
Transcription Factors
Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice
期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:
Guthrie L.M.
;
Soma S.
;
Yuan S.
;
Silva A.
;
Zulkifli M.
;
Snavely T.C.
;
Greene H.F.
;
Nunez E.
;
Lynch B.
;
de Ville C.
;
Shanbhag V.
;
Lopez F.R.
;
Acharya A.
;
Petris M.J.
;
Kim B.-E.
;
Gohil V.M.
;
Sacchettini J.C.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/28
copper
copper zinc superoxide dismutase
cytochrome c oxidase
dopamine beta monooxygenase
elesclomol
monophenol monooxygenase
protein lysine 6 oxidase
copper
cytochrome c oxidase
elesclomol
hydrazine derivative
copper
cytochrome
enzyme
enzyme activity
mitochondrion
mortality
mutation
pathology
rodent
survival
animal cell
animal experiment
animal model
animal tissue
Article
cohort analysis
controlled study
disease severity
drug mechanism
Golgi complex
H9c2(2-1) cell line
in vivo study
male
Menkes syndrome
mitochondrial dynamics
mortality rate
mouse
nerve degeneration
nonhuman
priority journal
secretory pathway
survival rate
animal
brain
cell line
degenerative disease
disease model
drug effect
genetics
knockout mouse
Menkes syndrome
metabolism
mitochondrion
pathology
rat
transport at the cellular level
Murinae
Mus
Animals
Biological Transport
Brain
Cell Line
Copper
Copper Transporter 1
Disease Models, Animal
Electron Transport Complex IV
Hydrazines
Male
Menkes Kinky Hair Syndrome
Mice
Mice, Knockout
Mitochondria
Neurodegenerative Diseases
Rats
PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis
期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:
Wang Q.
;
Boshoff H.I.M.
;
Harrison J.R.
;
Ray P.C.
;
Green S.R.
;
Wyatt P.G.
;
Barry Iii C.E.
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/28
3,3 bis di(methylsulfonyl)propionamide
antiinfective agent
bacterial protein
glucose
glycerol
magnesium
phosphate
propionamide derivative
protein proline proline glutamate
protein proline proline glutamate 51
unclassified drug
amide
bacterial protein
lipid
phthiocerol dimycocerosate
propionamide
thiol derivative
cell component
chemical compound
membrane
mutation
protein
tuberculosis
antibiotic resistance
Article
bacterial cell
bacterial cell wall
bacterial growth
bacterial outer membrane
cell division
drug structure
Mycobacterium tuberculosis
nonhuman
nutrient uptake
priority journal
protein depletion
cell membrane
cell membrane permeability
chemistry
drug effect
gene deletion
genetics
metabolism
transport at the cellular level
Mycobacterium tuberculosis
Amides
Bacterial Proteins
Biological Transport
Cell Membrane
Cell Membrane Permeability
Drug Resistance, Bacterial
Gene Deletion
Glucose
Glycerol
Lipids
Mycobacterium tuberculosis
Sulfhydryl Compounds
Polymerization in the actin ATPase clan regulates hexokinase activity in yeast
期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:
Stoddard P.R.
;
Lynch E.M.
;
Farrell D.P.
;
dosey A.M.
;
diMaio F.
;
Williams T.A.
;
Kollman J.M.
;
Murray A.W.
;
Garner E.C.
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/28
actin
adenosine triphosphatase
Glk1 protein
glucokinase
glucose
hexokinase
monomer
polymer
unclassified drug
carbohydrate
cell component
enzyme
enzyme activity
mutation
nutrient availability
polymer
polymerization
ultrastructure
actin filament
actin polymerization
Article
depolymerization
enzyme activity
enzyme inhibition
enzyme phosphorylation
nonhuman
nutrient availability
priority journal
protein blood level
Saccharomyces cerevisiae
Saccharomyces cerevisiae
Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia
期刊论文
, 2020, 卷号: 367, 期号: 6477
作者:
Uckelmann H.J.
;
Kim S.M.
;
Wong E.M.
;
Hatton C.
;
Giovinazzo H.
;
Gadrey J.Y.
;
Krivtsov A.V.
;
Rücker F.G.
;
Döhner K.
;
McGeehan G.M.
;
Levine R.L.
;
Bullinger L.
;
Vassiliou G.S.
;
Armstrong S.A.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/28
antileukemic agent
methionine
unclassified drug
vtp 50469
biological development
cancer
cell
disease treatment
mutation
numerical model
oral health
acute myeloid leukemia
animal cell
animal experiment
animal model
antineoplastic activity
Article
cell proliferation
cell self-renewal
chromatin
controlled study
drug targeting
gene
gene mutation
leukemia cell
molecularly targeted therapy
mouse
mouse model
nonhuman
NPM1 gene
preleukemia
priority journal
Mus
Insights into human genetic variation and population history from 929 diverse genomes
期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:
Bergström A.
;
McCarthy S.A.
;
Hui R.
;
Almarri M.A.
;
Ayub Q.
;
Danecek P.
;
Chen Y.
;
Felkel S.
;
Hallast P.
;
Kamm J.
;
Blanché H.
;
Deleuze J.-F.
;
Cann H.
;
Mallick S.
;
Reich D.
;
Sandhu M.S.
;
Skoglund P.
;
Scally A.
;
Xue Y.
;
Durbin R.
;
Tyler-Smith C.
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2020/07/28
ecozone
effective population size
genetic variation
genome
geographical region
hunter-gatherer
Neanderthal
population size
Africa
article
genetic variation
Homo denisovan
human
hunter-gatherer
nonhuman
population size
ancestry group
animal
Asia
copy number variation
genetics
haplotype
hominid
Homo neanderthalensis
human genome
indel mutation
Pacific islands
phylogeny
population density
population genetics
single nucleotide polymorphism
Western Hemisphere
whole genome sequencing
Africa
Central America
North America
South America
Africa
Americas
Animals
Asia
Continental Population Groups
DNA Copy Number Variations
Genetic Variation
Genetics, Population
Genome, Human
Haplotypes
Hominidae
Humans
INDEL Mutation
Neanderthals
Oceania
Phylogeny
Polymorphism, Single Nucleotide
Population Density
Whole Genome Sequencing