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| Sensitivities of simulated global aerosol optical depth and aerosol-radiation interactions to different horizontal resolutions in CAS-FGOALS-f3 期刊论文
ATMOSPHERIC ENVIRONMENT, 2022, 卷号: 271
作者: Zhao M.; Dai T.; Wang H.; Bao Q.; Liu Y.; Zhang H.; Shi G.
  收藏 | 浏览/下载：34/0 | 提交时间：2022/01/18
Aerosol optical depth Aerosol-radiation interaction CAS-FGOALS-f3 High resolution model |
| A versatile biosensing platform coupling CRISPR–Cas12a and aptamers for detection of diverse analytes 期刊论文
Science Bulletin, 2021, 卷号: 66, 期号: 1
作者: Zhao X.; Li S.; Liu G.; Wang Z.; Yang Z.; Zhang Q.; Liang M.; Liu J.; Li Z.; Tong Y.; Zhu G.; Wang X.; Jiang L.; Wang W.; Tan G.-Y.; Zhang L.
收藏 | 浏览/下载：33/0 | 提交时间：2021/09/01
Alpha fetoprotein detection Aptamer Biosensing platform Cocaine detection CRISPR–Cas12a Diverse analyte |
| Visualization and correction of social abnormalities-associated neural ensembles in adult MECP2 duplication mice 期刊论文
Science Bulletin, 2020, 卷号: 65, 期号: 14
作者: Sun L.; Chen R.; Li L.; Yuan B.; Song K.; Pan N.; Cheng T.-L.; Chang S.; Lin K.; He X.; Wu Q.; Xu F.; Qiu Z.; Wang X.
收藏 | 浏览/下载：208/0 | 提交时间：2021/09/01
Autism CRISPR/Cas9 In vivo calcium imaging MECP2 Social activity |
| A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity 期刊论文
, 2020, 卷号: 369, 期号: 6499
作者: Meeske A.J.; Jia N.; Cassel A.K.; Kozlova A.; Liao J.; Wiedmann M.; Patel D.J.; Marraffini L.A.
收藏 | 浏览/下载：39/0 | 提交时间：2020/07/28
CRISPR associated protein endonuclease guide RNA viral protein virus RNA bacteriophage clustered regularly interspaced short palindromic repeat CRISPR Cas system DNA cleavage genetics Listeria metabolism RNA stability virology Bacteriophages Clustered Regularly Interspaced Short Palindromic Repeats CRISPR-Associated Proteins CRISPR-Cas Systems DNA Cleavage Endonucleases Listeria RNA Stability RNA, Guide RNA, Viral Viral Proteins |
| Pervasive functional translation of noncanonical human open reading frames 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Chen J.; Brunner A.-D.; Cogan J.Z.; Nuñez J.K.; Fields A.P.; Adamson B.; Itzhak D.N.; Li J.Y.; Mann M.; Leonetti M.D.; Weissman J.S.
收藏 | 浏览/下载：30/0 | 提交时间：2020/07/28
messenger RNA peptide transcriptome CRISPR Cas system genetics human metabolism open reading frame operon protein synthesis ribosome CRISPR-Cas Systems Humans Open Reading Frames Operon Peptides Protein Biosynthesis Ribosomes RNA, Messenger Transcriptome |
| Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Walton R.T.; Christie K.A.; Whittaker M.N.; Kleinstiver B.P.
收藏 | 浏览/下载：27/0 | 提交时间：2020/07/28
adenine adenosine CRISPR associated endonuclease Cas9 cytosine guanosine SpG protein SpRY nuclease thymine unclassified drug Cas9 endonuclease Streptococcus pyogenes bacterium enzyme activity genetic engineering genetic variation genome Article CRISPR-CAS9 system DNA sequence enzyme activity gene editing gene targeting genetic variability human mutagenesis nonhuman priority journal protein engineering protein motif protein structure protospacer adjacent motif Streptococcus pyogenes chemistry CRISPR Cas system enzyme specificity gene editing gene targeting genetic predisposition genetics HEK293 cell line procedures protein domain Streptococcus pyogenes CRISPR-Associated Protein 9 CRISPR-Cas Systems Gene Editing Gene Targeting Genetic Predisposition to Disease HEK293 Cells Humans Mutagenesis Protein Domains Substrate Specificity |
| Modulating microbiome metabolites in vivo 期刊论文
, 2020, 卷号: 369, 期号: 6500
作者: Guo C.-J.
收藏 | 浏览/下载：22/0 | 提交时间：2020/07/28
Clostridium CRISPR Cas system genetics human intestine flora metabolism Clostridium CRISPR-Cas Systems Gastrointestinal Microbiome Host Microbial Interactions Humans |
| Very fast CRISPR on demand 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Liu Y.; Zou R.S.; He S.; Nihongaki Y.; Li X.; Razavi S.; Wu B.; Ha T.
收藏 | 浏览/下载：28/0 | 提交时间：2020/07/28
Cas9 endonuclease Streptococcus pyogenes double strand break repair protein MRE11 H2AX protein, human histone MRE11 protein, human CRISPR Cas system DNA cleavage DNA repair double stranded DNA break fluorescence imaging gene editing genetics HEK293 cell line human light metabolism phosphorylation procedures radiation response single cell analysis CRISPR-Associated Protein 9 CRISPR-Cas Systems DNA Breaks, Double-Stranded DNA Cleavage DNA Repair Gene Editing HEK293 Cells Histones Humans Light MRE11 Homologue Protein Optical Imaging Phosphorylation Single-Cell Analysis |
| Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者: Ebright R.Y.; Lee S.; Wittner B.S.; Niederhoffer K.L.; Nicholson B.T.; Bardia A.; Truesdell S.; Wiley D.F.; Wesley B.; Li S.; Mai A.; Aceto N.; Vincent-Jordan N.; Szabolcs A.; Chirn B.; Kreuzer J.; Comaills V.; Kalinich M.; Haas W.; Ting D.T.; Toner M.; Vasudevan S.; Haber D.A.; Maheswaran S.; Micalizzi D.S.
收藏 | 浏览/下载：55/0 | 提交时间：2020/07/28
CRISPR associated protein epidermal growth factor receptor 2 Ki 67 antigen ribosome protein ribosome RNA transcription factor E2F ribosome protein cancer cell gene expression genetic engineering protein RNA tumor animal experiment animal model animal tissue Article biogenesis bioluminescence breast cancer cell cycle progression cell cycle regulation cell proliferation circulating tumor cell controlled study enzyme activation epithelial mesenchymal transition gene expression profiling genetic transcription human human cell lung metastasis metastasis microfluidics mouse nonhuman overall survival phenotype priority journal progression free survival promoter region protein expression protein processing protein synthesis proteomics RNA sequence transcription regulation animal breast tumor cancer transplantation CRISPR Cas system female gene expression regulation genetics pathology sequence analysis tumor cell line tumor embolism Mus Animals Breast Neoplasms Cell Line, Tumor CRISPR-Cas Systems Female Gene Expression Regulation, Neoplastic Humans Mice Neoplasm Metastasis Neoplasm Transplantation Neoplastic Cells, Circulating Ribosomal Proteins Sequence Analysis, RNA |
| CRISPR-engineered T cells in patients with refractory cancer 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者: Stadtmauer E.A.; Fraietta J.A.; Davis M.M.; Cohen A.D.; Weber K.L.; Lancaster E.; Mangan P.A.; Kulikovskaya I.; Gupta M.; Chen F.; Tian L.; Gonzalez V.E.; Xu J.; Jung I.-Y.; Joseph Melenhorst J.; Plesa G.; Shea J.; Matlawski T.; Cervini A.; Gaymon A.L.; Desjardins S.; Lamontagne A.; Salas-Mckee J.; Fesnak A.; Siegel D.L.; Levine B.L.; Jadlowsky J.K.; Young R.M.; Chew A.; Hwang W.-T.; Hexner E.O.; Carreno B.M.; Nobles C.L.; Bushman F.D.; Parker K.R.; Qi Y.; Satpathy A.T.; Chang H.Y.; Zhao Y.; Lacey S.F.; June C.H.
收藏 | 浏览/下载：46/0 | 提交时间：2020/07/28
heterodimer programmed death 1 receptor T lymphocyte receptor alpha chain T lymphocyte receptor beta chain cancer cell gene gene expression genetic engineering immunity protein adult aged Article cancer patient cell engineering chromosome translocation clinical article clustered regularly interspaced short palindromic repeat controlled study CRISPR-CAS9 system feasibility study female gene editing gene expression gene frequency gene locus genetic code human human cell male middle aged myeloma PDCD1 gene phase 1 clinical trial priority journal sarcoma T lymphocyte TRAC gene TRBC gene tumor immunity |
