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Science [5]
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Transcription polymerase-catalyzed emergence of novel RNA replicons
期刊论文
, 2020, 卷号: 368, 期号: 6487
作者:
Jain N.
;
Blauch L.R.
;
Szymanski M.R.
;
Das R.
;
Tang S.K.Y.
;
Yin Y.W.
;
Fire A.Z.
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/28
cell component
enzyme
enzyme activity
genetic analysis
RNA
article
bacteriophage
catalysis
DNA replication origin
heredity
in vitro study
nonhuman
plant seed
replicon
RNA replication
synthesis
transcription initiation
biocatalysis
biosynthesis
genetic transcription
metabolism
Animalia
Hepatitis delta virus
Viroids
bacteriophage T7 RNA polymerase
DNA directed RNA polymerase
RNA
viral protein
Biocatalysis
DNA-Directed RNA Polymerases
Replicon
RNA
Transcription, Genetic
Viral Proteins
Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model
期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:
Rockx B.
;
Kuiken T.
;
Herfst S.
;
Bestebroer T.
;
Lamers M.M.
;
Munnink B.B.O.
;
De Meulder D.
;
Van Amerongen G.
;
Van Den Brand J.
;
Okba N.M.A.
;
Schipper D.
;
Van Run P.
;
Leijten L.
;
Sikkema R.
;
Verschoor E.
;
Verstrepen B.
;
Bogers W.
;
Langermans J.
;
Langermans J.
;
Drosten C.
;
Van Vlissingen M.F.
;
Fouchier R.
;
De Swart R.
;
Koopmans M.
;
Haagmans B.L.
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/28
pathogenicity
pathology
primate
severe acute respiratory syndrome
viral disease
virus
Middle East
Coronavirus
Macaca
Primates
SARS coronavirus
aging
animal
Betacoronavirus
comparative study
Coronavirus infection
disease model
female
isolation and purification
lung
lung alveolus
Macaca fascicularis
Middle East respiratory syndrome coronavirus
pandemic
pathogenicity
pathology
physiology
respiratory system
SARS coronavirus
severe acute respiratory syndrome
virology
virus pneumonia
virus replication
virus shedding
Aging
Animals
Betacoronavirus
Coronavirus Infections
Disease Models, Animal
Female
Lung
Macaca fascicularis
Middle East Respiratory Syndrome Coronavirus
Pandemics
Pneumonia, Viral
Pulmonary Alveoli
Respiratory System
SARS Virus
Severe Acute Respiratory Syndrome
Virus Replication
Virus Shedding
Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2
期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:
Shi J.
;
Wen Z.
;
Zhong G.
;
Yang H.
;
Wang C.
;
Huang B.
;
Liu R.
;
He X.
;
Shuai L.
;
Sun Z.
;
Zhao Y.
;
Liu P.
;
Liang L.
;
Cui P.
;
Wang J.
;
Zhang X.
;
Guan Y.
;
Tan W.
;
Wu G.
;
Chen H.
;
Bu Z.
;
Bu Z.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/28
bat
canid
disease control
disease transmission
felid
global perspective
infectious disease
poultry
severe acute respiratory syndrome
viral disease
virus
China
Hubei
Wuhan
Anas
Animalia
Canis familiaris
Coronavirus
Gallus gallus
Mustela
SARS coronavirus
Suidae
virus antibody
virus RNA
animal
Betacoronavirus
blood
cat
chicken
Coronavirus infection
disease model
disease predisposition
dog
domestic animal
duck
feces
female
immunology
isolation and purification
male
Mustela putorius furo
pandemic
physiology
pig
respiratory system
species difference
virology
virus attachment
virus pneumonia
virus replication
Animals
Animals, Domestic
Antibodies, Viral
Betacoronavirus
Cats
Chickens
Coronavirus Infections
Disease Models, Animal
Disease Susceptibility
Dogs
Ducks
Feces
Female
Ferrets
Male
Pandemics
Pneumonia, Viral
Respiratory System
RNA, Viral
Species Specificity
Sus scrofa
Virus Attachment
Virus Replication
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved a-ketoamide inhibitors
期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:
Zhang L.
;
Lin D.
;
Sun X.
;
Curth U.
;
Drosten C.
;
Sauerhering L.
;
Becker S.
;
Rox K.
;
Hilgenfeld R.
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/28
alanine
alpha ketoamide inhibitor
antivirus agent
isoleucine
leucine
proteinase
Severe acute respiratory syndrome coronavirus 2 main protease
threonine
unclassified drug
crystal structure
drug
enzyme
enzyme activity
inhibitor
reaction kinetics
amino acid sequence
animal cell
animal experiment
animal tissue
antiviral activity
Article
catalysis
catalytic efficiency
controlled study
crystal structure
dimerization
dissociation constant
drug clearance
drug design
drug distribution
drug half life
drug potency
drug protein binding
drug solubility
drug structure
EC50
enzyme inhibition
human
human cell
hydrogen bond
hydrophobicity
IC50
maximum concentration
mean residence time
metabolic stability
mouse
nonhuman
priority journal
protein structure
RNA replication
SARS coronavirus
Severe acute respiratory syndrome coronavirus 2
viral tropism
virus inhibition
Coronavirus
SARS coronavirus
Structural basis for transcriptional start site control of HIV-1 RNA fate
期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:
Brown J.D.
;
Kharytonchyk S.
;
Chaudry I.
;
Iyer A.S.
;
Carter H.
;
Becker G.
;
Desai Y.
;
Glang L.
;
Choi S.H.
;
Singh K.
;
Lopresti M.W.
;
Orellana M.
;
Rodriguez T.
;
Oboh U.
;
Hijji J.
;
Ghinger F.G.
;
Stewart K.
;
Francis D.
;
Edwards B.
;
Chen P.
;
Case D.A.
;
Telesnitsky A.
;
Summers M.F.
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/28
capped RNA
initiation factor 4E
messenger RNA
virus RNA
capped RNA
guanosine
initiation factor 4E
messenger RNA
virus RNA
cell
chemical binding
deuterium
genome
human immunodeficiency virus
physiological response
RNA
Article
base pairing
deuteron nuclear magnetic resonance
dimerization
DNA helix
energy transfer
gene control
gene function
gene number
human
Human immunodeficiency virus 1
nonhuman
priority journal
promoter region
RNA probe
RNA structure
RNA transcription
virus replication
5' untranslated region
base pairing
chemistry
DNA base composition
gene expression regulation
genetics
Human immunodeficiency virus 1
metabolism
nuclear magnetic resonance
protein synthesis
transcription initiation site
Eukaryota
Human immunodeficiency virus 1
5' Untranslated Regions
Base Composition
Base Pairing
Eukaryotic Initiation Factor-4E
Gene Expression Regulation, Viral
Guanosine
HIV-1
Humans
Nuclear Magnetic Resonance, Biomolecular
Protein Biosynthesis
RNA Caps
RNA, Messenger
RNA, Viral
Transcription Initiation Site