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De novo protein design enables the precise induction of RSV-neutralizing antibodies 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Sesterhenn F.;  Yang C.;  Bonet J.;  Cramer J.T.;  Wen X.;  Wang Y.;  Chiang C.-I.;  Abriata L.A.;  Kucharska I.;  Castoro G.;  Vollers S.S.;  Galloux M.;  Dheilly E.;  Rosset S.;  Corthésy P.;  Georgeon S.;  Villard M.;  Richard C.-A.;  Descamps D.;  Delgado T.;  Oricchio E.;  Rameix-Welti M.-A.;  Más V.;  Ervin S.;  Eléouët J.-F.;  Riffault S.;  Bates J.T.;  Julien J.-P.;  Li Y.;  Jardetzky T.;  Krey T.;  Correia B.E.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/28
algorithm  antibody  design  neutralization  protein  vaccine  Mus  Primates  Respiratory syncytial virus  Rice stripe virus  epitope  fusion protein  nanobody  neutralizing antibody  respiratory syncytial virus vaccine  biology  biosynthesis  chemistry  human  Human respiratory syncytial virus  immunology  procedures  protein conformation  protein engineering  protein motif  Amino Acid Motifs  Antibodies, Neutralizing  Computational Biology  Humans  Immunodominant Epitopes  Protein Conformation  Protein Engineering  Recombinant Fusion Proteins  Respiratory Syncytial Virus Vaccines  Respiratory Syncytial Virus, Human  Single-Domain Antibodies  
The genetic architecture of the human cerebral cortex 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Grasby K.L.;  Jahanshad N.;  Painter J.N.;  Colodro-Conde L.;  Bralten J.;  Hibar D.P.;  Lind P.A.;  Pizzagalli F.;  Ching C.R.K.;  McMahon M.A.B.;  Shatokhina N.;  Zsembik L.C.P.;  Thomopoulos S.I.;  Zhu A.H.;  Strike L.T.;  Agartz I.;  Alhusaini S.;  Almeida M.A.A.;  Alnæs D.;  Amlien I.K.;  Andersson M.;  Ard T.;  Armstrong N.J.;  Ashley-Koch A.;  Atkins J.R.;  Bernard M.;  Brouwer R.M.;  Buimer E.E.L.;  Bülow R.;  Bürger C.;  Cannon D.M.;  Chakravarty M.;  Chen Q.;  Cheung J.W.;  Couvy-Duchesne B.;  Dale A.M.;  Dalvie S.;  de Araujo T.K.;  de Zubicaray G.I.;  de Zwarte S.M.C.;  den Braber A.;  Doan N.T.;  Dohm K.;  Ehrlich S.;  Engelbrecht H.-R.;  Erk S.;  Fan C.C.;  Fedko I.O.;  Foley S.F.;  Ford J.M.;  Fukunaga M.;  Garrett M.E.;  Ge T.;  Giddaluru S.;  Goldman A.L.;  Green M.J.;  Groenewold N.A.;  Grotegerd D.;  Gurholt T.P.;  Gutman B.A.;  Hansell N.K.;  Harris M.A.;  Harrison M.B.;  Haswell C.C.;  Hauser M.;  Herms S.;  Heslenfeld D.J.;  Ho N.F.;  Hoehn D.;  Hoffmann P.;  Holleran L.;  Hoogman M.;  Hottenga J.-J.;  Ikeda M.;  Janowitz D.;  Jansen I.E.;  Jia T.;  Jockwitz C.;  Kanai R.;  Karama S.;  Kasperaviciute D.;  Kaufmann T.;  Kelly S.;  Kikuchi M.;  Klein M.;  Knapp M.;  Knodt A.R.;  Krämer B.;  Lam M.;  Lancaster T.M.;  Lee P.H.;  Lett T.A.;  Lewis L.B.;  Lopes-Cendes I.;  Luciano M.;  Macciardi F.;  Marquand A.F.;  Mathias S.R.;  Melzer T.R.;  Milaneschi Y.;  Mirza-Schreiber N.;  Moreira J.C.V.;  Mühleisen T.W.;  Müller-Myhsok B.;  Najt P.;  Nakahara S.;  Nho K.;  Olde Loohuis L.M.;  Orfanos D.P.;  Pearson J.F.;  Pitcher T.L.;  Pütz B.;  Quidé Y.;  Ragothaman A.;  Rashid F.M.;  Reay W.R.;  Redlich R.;  Reinbold C.S.;  Repple J.;  Richard G.;  Riedel B.C.;  Risacher S.L.;  Rocha C.S.;  Mota N.R.;  Salminen L.;  Saremi A.;  Saykin A.J.;  Schlag F.;  Schmaal L.;  Schofield P.R.;  Secolin R.;  Shapland C.Y.;  Shen L.;  Shin J.;  Shumskaya E.;  Sønderby I.E.;  Sprooten E.;  Tansey K.E.;  Teumer A.;  Thalamuthu A.;  Tordesillas-Gutiérrez D.;  Turner J.A.;  Uhlmann A.;  Vallerga C.L.;  van der Meer D.;  van Donkelaar M.M.J.;  van Eijk L.;  van Erp T.G.M.;  van Haren N.E.M.;  van Rooij D.;  van Tol M.-J.;  Veldink J.H.;  Verhoef E.;  Walton E.;  Wang M.;  Wang Y.;  Wardlaw J.M.;  Wen W.;  Westlye L.T.;  Whelan C.D.;  Witt S.H.;  Wittfeld K.;  Wolf C.;  Wolfers T.;  Wu J.Q.;  Yasuda C.L.;  Zaremba D.;  Zhang Z.;  Zwiers M.P.;  Artiges E.;  Assareh A.A.;  Ayesa-Arriola R.;  Belger A.;  Brandt C.L.;  Brown G.G.;  Cichon S.;  Curran J.E.;  Davies G.E.;  Degenhardt F.;  Dennis M.F.;  Dietsche B.;  Djurovic S.;  Doherty C.P.;  Espiritu R.;  Garijo D.;  Gil Y.;  Gowland P.A.;  Green R.C.;  Häusler A.N.;  Heindel W.;  Ho B.-C.;  Hoffmann W.U.;  Holsboer F.;  Homuth G.;  Hosten N.;  Jack C.R.;  Jang M.;  Jansen A.;  Kimbrel N.A.;  Kolskår K.;  Koops S.;  Krug A.;  Lim K.O.;  Luykx J.J.;  Mathalon D.H.;  Mather K.A.;  Mattay V.S.;  Matthews S.;  van Son J.M.;  McEwen S.C.;  Melle I.;  Morris D.W.;  Mueller B.A.;  Nauck M.;  Nordvik J.E.;  Nöthen M.M.;  O'Leary D.S.;  Opel N.;  Martinot M.-L.P.;  Bruce Pike G.;  Preda A.;  Quinlan E.B.;  Rasser P.E.;  Ratnakar V.;  Reppermund S.;  Steen V.M.;  Tooney P.A.;  Torres F.R.;  Veltman D.J.;  Voyvodic J.T.;  Whelan R.;  White T.;  Yamamori H.;  Adams H.H.H.;  Bis J.C.;  Debette S.;  Decarli C.;  Fornage M.;  Gudnason V.;  Hofer E.;  Arfan Ikram M.;  Launer L.;  Longstreth W.T.;  Lopez O.L.;  Mazoyer B.;  Mosley T.H.;  Roshchupkin G.V.;  Satizabal C.L.;  Schmidt R.;  Seshadri S.;  Yang Q.;  Alvim M.K.M.;  Ames D.;  Anderson T.J.;  Andreassen O.A.;  Arias-Vasquez A.;  Bastin M.E.;  Baune B.T.;  Beckham J.C.;  Blangero J.;  Boomsma D.I.;  Brodaty H.;  Brunner H.G.;  Buckner R.L.;  Buitelaar J.K.;  Bustillo J.R.;  Cahn W.;  Cairns M.J.;  Calhoun V.;  Carr V.J.;  Caseras X.;  Caspers S.;  Cavalleri G.L.;  Cendes F.;  Corvin A.;  Crespo-Facorro B.;  Dalrymple-Alford J.C.;  Dannlowski U.;  de Geus E.J.C.;  Deary I.J.;  Delanty N.;  Depondt C.;  Desrivières S.;  Donohoe G.;  Espeseth T.;  Fernández G.;  Fisher S.E.;  Flor H.;  Forstner A.J.;  Francks C.;  Franke B.;  Glahn D.C.;  Gollub R.L.;  Grabe H.J.;  Gruber O.;  Håberg A.K.;  Hariri A.R.;  Hartman C.A.;  Hashimoto R.;  Heinz A.;  Henskens F.A.;  Hillegers M.H.J.;  Hoekstra P.J.;  Holmes A.J.;  Elliot Hong L.;  Hopkins W.D.;  Hulshoff Pol H.E.;  Jernigan T.L.;  Jönsson E.G.;  Kahn R.S.;  Kennedy M.A.;  Kircher T.T.J.;  Kochunov P.;  Kwok J.B.J.;  Le Hellard S.;  Loughland C.M.;  Martin N.G.;  Martinot J.-L.;  McDonald C.;  McMahon K.L.;  Meyer-Lindenberg A.;  Michie P.T.;  Morey R.A.;  Mowry B.;  Nyberg L.;  Oosterlaan J.;  Ophoff R.A.;  Pantelis C.;  Paus T.;  Pausova Z.;  Penninx B.W.J.H.;  Polderman T.J.C.;  Posthuma D.;  Rietschel M.;  Roffman J.L.;  Rowland L.M.;  Sachdev P.S.;  Sämann P.G.;  Schall U.;  Schumann G.;  Scott R.J.;  Sim K.;  Sisodiya S.M.;  Smoller J.W.;  Sommer I.E.;  Pourcain B.S.;  Stein D.J.;  Toga A.W.;  Trollor J.N.;  van der Wee N.J.A.;  van't Ent D.;  Völzke H.;  Walter H.;  Weber B.;  Weinberger D.R.;  Wright M.J.;  Zhou J.;  Stein J.L.;  Thompson P.M.;  Medland S.E.;  Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group
收藏  |  浏览/下载：47/0  |  提交时间：2020/07/28
brain  genetic analysis  meta-analysis  resonance  signaling  surface area  Article  bioinformatics  brain cortex  brain function  brain region  brain tissue  cortical thickness (brain)  educational status  evidence based medicine  gene control  gene locus  genetic association  genetic correlation  genetic variability  genome-wide association study  human  human genetics  priority journal  surface area  tissue structure  Wnt signaling  anatomy and histology  attention deficit disorder  brain cortex  brain mapping  cognition  genetic variation  genetics  meta analysis  nuclear magnetic resonance imaging  organ size  Parkinson disease  Attention Deficit Disorder with Hyperactivity  Brain Mapping  Cerebral Cortex  Cognition  Genetic Loci  Genetic Variation  Genome-Wide Association Study  Humans  Magnetic Resonance Imaging  Organ Size  Parkinson Disease  
Structural basis of Gs and Gi recognition by the human glucagon receptor 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Qiao A.;  Han S.;  Li X.;  Li Z.;  Zhao P.;  Dai A.;  Chang R.;  Tai L.;  Tan Q.;  Chu X.;  Ma L.;  Thorsen T.S.;  Reedtz-Runge S.;  Yang D.;  Wang M.-W.;  Sexton P.M.;  Wootten D.;  Sun F.;  Zhao Q.;  Wu B.
收藏  |  浏览/下载：31/0  |  提交时间：2020/07/28
cyclic AMP  glucagon  glucagon receptor  inhibitory guanine nucleotide binding protein  stimulatory guanine nucleotide binding protein  glucagon receptor  inhibitory guanine nucleotide binding protein  protein binding  stimulatory guanine nucleotide binding protein  chemical binding  enzyme activity  gene expression  mutagenicity  protein  alpha helix  Article  binding affinity  carboxy terminal sequence  conformational transition  cryoelectron microscopy  human  molecular recognition  mutagenesis  priority journal  protein binding  protein function  protein protein interaction  protein structure  signal transduction  binding site  chemistry  metabolism  molecular model  protein conformation  ultrastructure  Binding Sites  Cryoelectron Microscopy  Glucagon  GTP-Binding Protein alpha Subunits, Gi-Go  GTP-Binding Protein alpha Subunits, Gs  Humans  Models, Molecular  Protein Binding  Protein Conformation  Protein Conformation, alpha-Helical  Receptors, Glucagon  Signal Transduction  
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells 期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:  Zhou Z.;  He H.;  Wang K.;  Shi X.;  Wang Y.;  Su Y.;  Wang Y.;  Li D.;  Liu W.;  Zhang Y.;  Shen L.;  Han W.;  Shen L.;  Ding J.;  Shao F.
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/28
cell  cell component  cytology  enzyme  enzyme activity  gene expression  immunity  tumor  Mus  gamma interferon  granzyme  GSDMB protein, human  GZMA protein, human  pore forming cytotoxic protein  tumor protein  animal  Bagg albino mouse  chemistry  cytotoxic T lymphocyte  enzymology  genetics  HEK293 cell line  human  immunology  metabolism  mouse  natural killer cell  neoplasm  pathology  protein degradation  protein domain  pyroptosis  transgenic mouse  Animals  Granzymes  HEK293 Cells  Humans  Interferon-gamma  Killer Cells, Natural  Mice  Mice, Inbred BALB C  Mice, Transgenic  Neoplasm Proteins  Neoplasms  Pore Forming Cytotoxic Proteins  Protein Domains  Proteolysis  Pyroptosis  T-Lymphocytes, Cytotoxic  
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Wu Y.;  Wang F.;  Shen C.;  Peng W.;  Li D.;  Zhao C.;  Li Z.;  Li S.;  Bi Y.;  Yang Y.;  Gong Y.;  Xiao H.;  Fan Z.;  Tan S.;  Wu G.;  Tan W.;  Lu X.;  Fan C.;  Wang Q.;  Liu Y.;  Zhang C.;  Qi J.;  Gao G.F.;  Gao F.;  Liu L.
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/28
Coronavirus  angiotensin converting enzyme 2  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  monoclonal antibody  neutralizing antibody  virus antibody  virus receptor  animal  chemistry  Coronavirus infection  disease model  human  immunology  isolation and purification  lung  mouse  pandemic  protein domain  serodiagnosis  virology  virus load  virus pneumonia  Animals  Antibodies, Monoclonal  Antibodies, Neutralizing  Antibodies, Viral  Coronavirus Infections  Disease Models, Animal  Humans  Immunodominant Epitopes  Lung  Mice  Neutralization Tests  Pandemics  Peptidyl-Dipeptidase A  Pneumonia, Viral  Protein Domains  Receptors, Virus  Spike Glycoprotein, Coronavirus  Viral Load  
CO2 electrolysis to multicarbon products at activities greater than 1 A cm−2 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  García de Arquer F.P.;  Dinh C.-T.;  Ozden A.;  Wicks J.;  McCallum C.;  Kirmani A.R.;  Nam D.-H.;  Gabardo C.;  Seifitokaldani A.;  Wang X.;  Li Y.C.;  Li F.;  Edwards J.;  Richter L.J.;  Thorpe S.J.;  Sinton D.;  Sargent E.H.
收藏  |  浏览/下载：17/0  |  提交时间：2020/07/28
carbon dioxide  ethylene  potassium hydroxide  carbon dioxide  catalyst  electrode  electrokinesis  energy efficiency  greenhouse gas  hydrophobicity  ion  Article  catalyst  current density  electrolysis  electron transport  gas transport  hydrophilicity  hydrophobicity  ion transport  particle size  priority journal  reduction (chemistry)