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Ancient origins of allosteric activation in a Ser-Thr kinase 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Hadzipasic A.;  Wilson C.;  Nguyen V.;  Kern N.;  Kim C.;  Pitsawong W.;  Villali J.;  Zheng Y.;  Kern D.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
aurora A kinase  microtubule associated protein  TPX2 protein  unclassified drug  activation energy  ancestry  cell  chemical binding  experimental study  fitness  protein  allosterism  amino acid sequence  Article  binding affinity  binding site  enzyme activation  enzyme activity  enzyme binding  enzyme localization  enzyme phosphorylation  gene duplication  horizontal gene transfer  human  hydrophobicity  intracellular signaling  phylogenetic tree  phylogeny  priority journal  protein binding  protein localization  protein protein interaction  
Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Neubarth N.L.;  Emanuel A.J.;  Liu Y.;  Springel M.W.;  Handler A.;  Zhang Q.;  Lehnert B.P.;  Guo C.;  Orefice L.L.;  Abdelaziz A.;  DeLisle M.M.;  Iskols M.;  Rhyins J.;  Kim S.J.;  Cattel S.J.;  Regehr W.;  Harvey C.D.;  Drugowitsch J.;  Ginty D.D.
收藏  |  浏览/下载：32/0  |  提交时间：2020/07/28
chemical cue  mechanoreception  perception  reaction kinetics  skin  visual cue  Mammalia  Mus  Bdnf protein, mouse  brain derived neurotrophic factor  membrane protein  Ntrk2 protein, mouse  protein tyrosine kinase  animal  C57BL mouse  electron microscopy  epidermis  female  genetics  innervation  knockout mouse  male  Merkel cell  metabolism  mouse  physiology  signal transduction  touch  ultrastructure  Animals  Brain-Derived Neurotrophic Factor  Epidermis  Female  Male  Membrane Glycoproteins  Merkel Cells  Mice  Mice, Inbred C57BL  Mice, Knockout  Microscopy, Electron  Protein-Tyrosine Kinases  Signal Transduction  Touch  Touch Perception  
Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1 期刊论文
, 2020, 卷号: 367, 期号: 6474
作者:  Yoon I.;  Nam M.;  Kim H.K.;  Moon H.-S.;  Kim S.;  Jang J.;  Song J.A.;  Jeong S.J.;  Kim S.B.;  Cho S.;  Kim Y.;  Lee J.;  Yang W.S.;  Yoo H.C.;  Kim K.;  Kim M.-S.;  Yang A.;  Cho K.;  Park H.-S.;  Hwang G.-S.;  Hwang K.Y.;  Han J.M.;  Kim J.H.;  Kim S.
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/28
glucose  leucine  leucine transfer RNA ligase  leucyl tRNA synthetase 1  mammalian target of rapamycin complex 1  S6 kinase  serine threonine protein kinase ULK1  unclassified drug  glucose  leucine  leucine transfer RNA ligase  mammalian target of rapamycin complex 1  monomeric guanine nucleotide binding protein  serine threonine protein kinase ULK1  catabolism  cell  enzyme  enzyme activity  glucose  metabolism  protein  survival  amino acid metabolism  animal cell  Article  binding affinity  cell survival  circular dichroism  controlled study  embryo  energy yield  enzyme activity  enzyme phosphorylation  enzyme regulation  fluorescence resonance energy transfer  human  human cell  mouse  nonhuman  priority journal  protein binding  protein domain  protein motif  protein processing  protein synthesis  signal transduction  starvation  animal  energy metabolism  fibroblast  genetics  HEK293 cell line  HeLa cell line  lysosome  metabolism  phosphorylation  Animals  Autophagy-Related Protein-1 Homolog  Energy Metabolism  Fibroblasts  Glucose  HEK293 Cells  HeLa Cells  Humans  Leucine  Leucine-tRNA Ligase  Lysosomes  Mechanistic Target of Rapamycin Complex 1  Mice  Monomeric GTP-Binding Proteins  Phosphorylation  Signal Transduction  
Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Liu J.;  Kim Y.S.;  Richardson C.E.;  Tom A.;  Ramakrishnan C.;  Birey F.;  Katsumata T.;  Chen S.;  Wang C.;  Wang X.;  Joubert L.-M.;  Jiang Y.;  Wang H.;  Fenno L.E.;  Tok J.B.-H.;  Paşca S.P.;  Shen K.;  Bao Z.;  Deisseroth K.
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/28
poly(3,4 ethylenedioxythiophene)  polyaniline  polymer  unclassified drug  3-nitro-o-phenylenediamine  aniline  aniline derivative  ascorbate peroxidase  nitro derivative  phenylenediamine derivative  polymer  anatomy  genetic engineering  membrane  physiological response  polymer  animal cell  Article  biocompatibility  brain nerve cell  brain slice  Caenorhabditis elegans  cell membrane  cell viability  controlled study  genetic procedures  genetically targeted chemical assemby  hippocampal neuronal culture  human  human cell  in vivo study  nerve cell membrane  nonhuman  polymerization  priority journal  rat  synthesis  action potential  animal  cell culture  cell survival  chemistry  electric conductivity  enzymology  genetic engineering  genetic transduction  genetics  HEK293 cell line  hippocampus  membrane potential  metabolism  motoneuron  mouse  muscle cell  nerve cell  patch clamp technique  physiology  Animalia  Action Potentials  Aniline Compounds  Animals  Ascorbate Peroxidases  Caenorhabditis elegans  Cell Membrane  Cell Survival  Cells, Cultured  Electric Conductivity  Genetic Engineering  HEK293 Cells  Hippocampus  Humans  Membrane Potentials  Mice  Motor Neurons  Muscle Cells  Neurons  Nitro Compounds  Patch-Clamp Techniques  Phenylenediamines  Polymers  Rats  Transduction, Genetic