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文献类型
期刊论文 [4]
发表日期
2020 [4]
语种
英语 [4]
来源机构
Science [4]
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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:
Dai W.
;
Zhang B.
;
Jiang X.-M.
;
Su H.
;
Li J.
;
Zhao Y.
;
Xie X.
;
Jin Z.
;
Peng J.
;
Liu F.
;
Li C.
;
Li Y.
;
Bai F.
;
Wang H.
;
Cheng X.
;
Cen X.
;
Hu S.
;
Yang X.
;
Wang J.
;
Liu X.
;
Xiao G.
;
Jiang H.
;
Rao Z.
;
Zhang L.-K.
;
Xu Y.
;
Yang H.
;
Liu H.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/28
aldehyde
antimicrobial activity
drug
enzyme activity
infectivity
inhibitor
reaction kinetics
viral disease
Coronavirus
SARS coronavirus
3C-like proteinase, Coronavirus
antivirus agent
cysteine proteinase
viral protein
animal
Betacoronavirus
chemical structure
chemistry
Chlorocebus aethiops
Coronavirus infection
dog
drug design
drug effect
enzyme active site
enzymology
female
human
male
mouse
pandemic
preclinical study
protein tertiary structure
Sprague Dawley rat
toxicity testing
Vero cell line
virus pneumonia
Animals
Antiviral Agents
Betacoronavirus
Catalytic Domain
Chlorocebus aethiops
Coronavirus Infections
Cysteine Endopeptidases
Dogs
Drug Design
Drug Evaluation, Preclinical
Female
Humans
Male
Mice
Molecular Structure
Pandemics
Pneumonia, Viral
Protein Structure, Tertiary
Rats, Sprague-Dawley
Toxicity Tests
Vero Cells
Viral Nonstructural Proteins
Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity
期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:
Wang J.
;
Li P.
;
Yu Y.
;
Fu Y.
;
Jiang H.
;
Lu M.
;
Sun Z.
;
Jiang S.
;
Lu L.
;
Wu M.X.
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/28
2',3' cyclic guanosine monophosphate adenosine monophosphate
influenza vaccine
interferon
nanoparticle
pulmonary surfactant biomimetic nanoparticle
purine nucleotide
surfactant protein A
surfactant protein D
unclassified drug
cell
drug resistance
immune response
immunity
induced response
influenza
nanoparticle
rodent
surfactant
vaccine
animal cell
animal experiment
animal model
animal tissue
Article
CD8+ T lymphocyte
cellular immunity
controlled study
cross protection
cytokine response
drug efficacy
drug safety
drug synthesis
female
human
humoral immunity
hydrophilicity
immune response
immunopathology
immunosurveillance
influenza
innate immunity
lung alveolus epithelium cell
lung alveolus macrophage
mouse
Mustela putorius furo
nanoencapsulation
nonhuman
priority journal
Mus
Mustela
An atlas of the protein-coding genes in the human, pig, and mouse brain
期刊论文
, 2020, 卷号: 367, 期号: 6482
作者:
Sjöstedt E.
;
Zhong W.
;
Fagerberg L.
;
Karlsson M.
;
Mitsios N.
;
Adori C.
;
Oksvold P.
;
Edfors F.
;
Limiszewska A.
;
Hikmet F.
;
Huang J.
;
Du Y.
;
Lin L.
;
Dong Z.
;
Yang L.
;
Liu X.
;
Jiang H.
;
Xu X.
;
Wang J.
;
Yang H.
;
Bolund L.
;
Mardinoglu A.
;
Zhang C.
;
Von Feilitzen K.
;
Lindskog C.
;
Pontén F.
;
Luo Y.
;
Hökfelt T.
;
Uhlén M.
;
Mulder J.
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/28
G protein coupled receptor
neurotransmitter
atlas
brain
gene
gene expression
pig
protein
Article
astrocyte
cerebellum
gene expression level
gene expression profiling
gene mapping
genetic code
genome-wide association study
genomics
human
hypothalamus
in situ hybridization
microglia
nerve cell
nonhuman
oligodendroglia
pig
priority journal
species comparison
tissue specificity
transcriptomics
Mammalia
Suidae
Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals
期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:
Liu J.
;
Kim Y.S.
;
Richardson C.E.
;
Tom A.
;
Ramakrishnan C.
;
Birey F.
;
Katsumata T.
;
Chen S.
;
Wang C.
;
Wang X.
;
Joubert L.-M.
;
Jiang Y.
;
Wang H.
;
Fenno L.E.
;
Tok J.B.-H.
;
Paşca S.P.
;
Shen K.
;
Bao Z.
;
Deisseroth K.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/28
poly(3,4 ethylenedioxythiophene)
polyaniline
polymer
unclassified drug
3-nitro-o-phenylenediamine
aniline
aniline derivative
ascorbate peroxidase
nitro derivative
phenylenediamine derivative
polymer
anatomy
genetic engineering
membrane
physiological response
polymer
animal cell
Article
biocompatibility
brain nerve cell
brain slice
Caenorhabditis elegans
cell membrane
cell viability
controlled study
genetic procedures
genetically targeted chemical assemby
hippocampal neuronal culture
human
human cell
in vivo study
nerve cell membrane
nonhuman
polymerization
priority journal
rat
synthesis
action potential
animal
cell culture
cell survival
chemistry
electric conductivity
enzymology
genetic engineering
genetic transduction
genetics
HEK293 cell line
hippocampus
membrane potential
metabolism
motoneuron
mouse
muscle cell
nerve cell
patch clamp technique
physiology
Animalia
Action Potentials
Aniline Compounds
Animals
Ascorbate Peroxidases
Caenorhabditis elegans
Cell Membrane
Cell Survival
Cells, Cultured
Electric Conductivity
Genetic Engineering
HEK293 Cells
Hippocampus
Humans
Membrane Potentials
Mice
Motor Neurons
Muscle Cells
Neurons
Nitro Compounds
Patch-Clamp Techniques
Phenylenediamines
Polymers
Rats
Transduction, Genetic