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Sars-cov-2 induces double-stranded rna-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 16
作者:  Li Y.;  Renner D.M.;  Comar C.E.;  Whelan J.N.;  Reyes H.M.;  Cardenas-Diaz F.L.;  Truitt R.;  Tan L.H.;  Dong B.;  Alysandratos K.D.;  Huang J.;  Palmer J.N.;  Adappa N.D.;  Kohanski M.A.;  Kotton D.N.;  Silverman R.H.;  Yang W.;  Morrisey E.E.;  Cohen N.A.;  Weiss S.R.
收藏  |  浏览/下载：30/0  |  提交时间：2021/05/24
CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 13
作者:  Russell R.M.;  Bibollet-Ruche F.;  Liu W.;  Sherrill-Mix S.;  Li Y.;  Connell J.;  Loy D.E.;  Trimboli S.;  Smith A.G.;  Avitto A.N.;  Gondim M.V.P.;  Plenderleith L.J.;  Wetzel K.S.;  Collman R.G.;  Ayouba A.;  Esteban A.;  Peeters M.;  Kohler W.J.;  Miller R.A.;  François-Souquiere S.;  Switzer W.M.;  Hirsch V.M.;  Marx P.A.;  Piel A.K.;  Stewart F.A.;  Georgiev A.V.;  Sommer V.;  Bertolani P.;  Hart J.A.;  Hart T.B.;  Shaw G.M.;  Sharp P.M.;  Hahn B.H.
收藏  |  浏览/下载：37/0  |  提交时间：2021/05/24
Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2 期刊论文
Science Bulletin, 2020
作者:  Gu C.;  Wu Y.;  Guo H.;  Zhu Y.;  Xu W.;  Wang Y.;  Zhou Y.;  Sun Z.;  Cai X.;  Li Y.;  Liu J.;  Huang Z.;  Yuan Z.;  Zhang R.;  Deng Q.;  Qu D.;  Xie Y.
收藏  |  浏览/下载：20/0  |  提交时间：2021/09/01
ACE2  Protoporphyrin IX  SARS-CoV-2  Verteporfin  
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Dai W.;  Zhang B.;  Jiang X.-M.;  Su H.;  Li J.;  Zhao Y.;  Xie X.;  Jin Z.;  Peng J.;  Liu F.;  Li C.;  Li Y.;  Bai F.;  Wang H.;  Cheng X.;  Cen X.;  Hu S.;  Yang X.;  Wang J.;  Liu X.;  Xiao G.;  Jiang H.;  Rao Z.;  Zhang L.-K.;  Xu Y.;  Yang H.;  Liu H.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
aldehyde  antimicrobial activity  drug  enzyme activity  infectivity  inhibitor  reaction kinetics  viral disease  Coronavirus  SARS coronavirus  3C-like proteinase, Coronavirus  antivirus agent  cysteine proteinase  viral protein  animal  Betacoronavirus  chemical structure  chemistry  Chlorocebus aethiops  Coronavirus infection  dog  drug design  drug effect  enzyme active site  enzymology  female  human  male  mouse  pandemic  preclinical study  protein tertiary structure  Sprague Dawley rat  toxicity testing  Vero cell line  virus pneumonia  Animals  Antiviral Agents  Betacoronavirus  Catalytic Domain  Chlorocebus aethiops  Coronavirus Infections  Cysteine Endopeptidases  Dogs  Drug Design  Drug Evaluation, Preclinical  Female  Humans  Male  Mice  Molecular Structure  Pandemics  Pneumonia, Viral  Protein Structure, Tertiary  Rats, Sprague-Dawley  Toxicity Tests  Vero Cells  Viral Nonstructural Proteins  
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:  Yan R.;  Zhang Y.;  Li Y.;  Xia L.;  Guo Y.;  Zhou Q.
收藏  |  浏览/下载：17/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  coronavirus spike glycoprotein  heterodimer  homodimer  amino acid transporter  angiotensin converting enzyme 2  dipeptidyl carboxypeptidase  protein binding  SLC6A19 protein, human  spike protein, SARS-CoV-2  virus receptor  enzyme  gene  gene expression  protein  ultrastructure  virus  Article  binding site  complex formation  controlled study  coronavirus disease 2019  cryoelectron microscopy  dimerization  embryo  enzyme structure  human  human cell  nonhuman  priority journal  protein domain  SARS-related coronavirus  Severe acute respiratory syndrome coronavirus 2  amino acid sequence  Betacoronavirus  Coronavirus infection  molecular model  pandemic  protein multimerization  SARS coronavirus  sequence alignment  ultrastructure  virus pneumonia  Coronavirus  SARS coronavirus  Amino Acid Sequence  Amino Acid Transport Systems, Neutral  Betacoronavirus  Coronavirus Infections  Cryoelectron Microscopy  Humans  Models, Molecular  Pandemics  Peptidyl-Dipeptidase A  Pneumonia, Viral  Protein Binding  Protein Domains  Protein Multimerization  Receptors, Virus  SARS Virus  Sequence Alignment  Spike Glycoprotein, Coronavirus