气候变化领域集成服务门户(CCPortal): CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses

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DOI	10.1073/PNAS.2025914118
	CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses
	Russell R.M.; Bibollet-Ruche F.; Liu W.; Sherrill-Mix S.; Li Y.; Connell J.; Loy D.E.; Trimboli S.; Smith A.G.; Avitto A.N.; Gondim M.V.P.; Plenderleith L.J.; Wetzel K.S.; Collman R.G.; Ayouba A.; Esteban A.; Peeters M.; Kohler W.J.; Miller R.A.; François-Souquiere S.; Switzer W.M.; Hirsch V.M.; Marx P.A.; Piel A.K.; Stewart F.A.; Georgiev A.V.; Sommer V.; Bertolani P.; Hart J.A.; Hart T.B.; Shaw G.M.; Sharp P.M.; Hahn B.H.
发表日期	2021
ISSN	00278424
卷号	118 期号:13
英文摘要	Infection with human and simian immunodeficiency viruses (HIV/ SIV) requires binding of the viral envelope glycoprotein (Env) to the host protein CD4 on the surface of immune cells. Although invariant in humans, the Env binding domain of the chimpanzee CD4 is highly polymorphic, with nine coding variants circulating in wild populations. Here, we show that within-species CD4 diversity is not unique to chimpanzees but found in many African primate species. Characterizing the outermost (D1) domain of the CD4 protein in over 500 monkeys and apes, we found polymorphic residues in 24 of 29 primate species, with as many as 11 different coding variants identified within a single species. D1 domain amino acid replacements affected SIV Env-mediated cell entry in a single-round infection assay, restricting infection in a strain- and allele-specific fashion. Several identical CD4 polymorphisms, including the addition of N-linked glycosylation sites, were found in primate species from different genera, providing striking examples of parallel evolution. Moreover, seven different guenons (Cercopithecus spp.) shared multiple distinct D1 domain variants, pointing to long-term trans-specific polymorphism. These data indicate that the HIV/SIV Env binding region of the primate CD4 protein is highly variable, both within and between species, and suggest that this diversity has been maintained by balancing selection for millions of years, at least in part to confer protection against primate lentiviruses. Although long-term SIV-infected species have evolved specific mechanisms to avoid disease progression, primate lentiviruses are intrinsically pathogenic and have left their mark on the host genome. © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Balancing selection; CD4; Parallel evolution; Primate lentiviruses; Trans-specific polymorphism
语种	英语
scopus关键词	CD4 antigen; virus envelope protein; allele; amino acid substitution; Article; cell function; Cercopithecus; chimpanzee; controlled study; disease course; genetic transfection; genotype; infection prevention; nonhuman; pathogenicity; phylogeny; Primate lentivirus; priority journal; protein analysis; protein binding; protein domain; protein glycosylation; protein polymorphism; RNA extraction; RNA sequencing; simian acquired immunodeficiency syndrome; species diversity
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180043
作者单位	Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States; Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, United States; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, EH9 3FL, United Kingdom; Centre for Immunity, Infection, and Evolution, University of Edinburgh, Edinburgh, EH9 3FL, United Kingdom; Recherche Translationnelle Appliquée au VIH et aux Maladies Infectieuses, Institut de Recherche pour le Développement, University of Montpellier, INSERM, Montpellier, 34090, France; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, United States; Hepatology and Gastroenterology Unit, University Hospital of Limoges, Limoges, 87042, France; Laboratory Branch, Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30329, United States; Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, United States; D...
推荐引用方式 GB/T 7714	Russell R.M.,Bibollet-Ruche F.,Liu W.,et al. CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses[J],2021,118(13).
APA	Russell R.M..,Bibollet-Ruche F..,Liu W..,Sherrill-Mix S..,Li Y..,...&Hahn B.H..(2021).CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses.Proceedings of the National Academy of Sciences of the United States of America,118(13).
MLA	Russell R.M.,et al."CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses".Proceedings of the National Academy of Sciences of the United States of America 118.13(2021).