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| Hygroscopic properties and compositional evolution of internally mixed sodium nitrate-amino acid aerosols 期刊论文 ATMOSPHERIC ENVIRONMENT, 2020, 卷号: 242 作者: Guo Y.; Wang N.; Pang S.; Zhang Y. 收藏  |  浏览/下载:28/0  |  提交时间:2022/01/18 Amino acid ATR-FTIR Hygroscopic properties NaNO3-Amino acid complex salts |
| Bioaccumulation of heavy metals; antioxidants; and metabolic enzymes in the crab Scylla serrata from different regions of Tuticorin; Southeast Coast of India 期刊论文 Marine Pollution Bulletin, 2020, 卷号: 158 作者: Yogeshwaran A.; Gayathiri K.; Muralisankar T.; Gayathri V.; Monica J.I.; Rajaram R.; Marimuthu K.; Bhavan P.S. 收藏  |  浏览/下载:19/0  |  提交时间:2020/11/23 |
| Detecting illegal cyanide fishing: Establishing the evidence base for a reliable; post-collection test 期刊论文 Marine Pollution Bulletin, 2020, 卷号: 150 作者: Murray J.M.; Bersuder P.; Davis S.; Losada S. 收藏  |  浏览/下载:21/0  |  提交时间:2020/11/23 |
| Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文 , 2020, 卷号: 368, 期号: 6492 作者: Gao Y.; Yan L.; Huang Y.; Liu F.; Zhao Y.; Cao L.; Wang T.; Sun Q.; Ming Z.; Zhang L.; Ge J.; Zheng L.; Zhang Y.; Wang H.; Zhu Y.; Zhu C.; Hu T.; Hua T.; Zhang B.; Yang X.; Li J.; Yang H.; Liu Z.; Xu W.; Guddat L.W.; Wang Q.; Lou Z.; Rao Z. 收藏  |  浏览/下载:38/0  |  提交时间:2020/07/28 comparative study drug electron microscopy enzyme enzyme activity RNA virus Coronavirus SARS coronavirus adenosine phosphate alanine antivirus agent NSP7 protein, SARS-CoV-2 NSP8 protein, SARS-CoV-2 remdesivir RNA directed RNA polymerase RNA-dependent RNA polymerase, coronavirus viral protein beta sheet Betacoronavirus chemistry cryoelectron microscopy drug design enzyme active site enzymology metabolism molecular model protein domain ultrastructure Adenosine Monophosphate Alanine Antiviral Agents Betacoronavirus Catalytic Domain Cryoelectron Microscopy Drug Design Models, Molecular Protein Conformation, beta-Strand Protein Domains RNA Replicase Viral Nonstructural Proteins |
| Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir 期刊论文 , 2020, 卷号: 368, 期号: 6498 作者: Yin W.; Mao C.; Luan X.; Shen D.-D.; Shen Q.; Su H.; Wang X.; Zhou F.; Zhao W.; Gao M.; Chang S.; Xie Y.-C.; Tian G.; Jiang H.-W.; Tao S.-C.; Shen J.; Jiang Y.; Jiang H.; Xu Y.; Zhang S.; Zhang Y.; Xu H.E. 收藏  |  浏览/下载:107/0  |  提交时间:2020/07/28 adenosine phosphate alanine antivirus agent enzyme inhibitor multiprotein complex NSP7 protein, SARS-CoV-2 NSP8 protein, SARS-CoV-2 remdesivir RNA directed RNA polymerase RNA-dependent RNA polymerase, coronavirus viral protein virus RNA Betacoronavirus chemistry cryoelectron microscopy drug effect enzyme active site enzymology metabolism molecular model physiology protein conformation virus replication Adenosine Monophosphate Alanine Antiviral Agents Betacoronavirus Catalytic Domain Cryoelectron Microscopy Enzyme Inhibitors Models, Molecular Multiprotein Complexes Protein Conformation RNA Replicase RNA, Viral Viral Nonstructural Proteins Virus Replication |
| Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved a-ketoamide inhibitors 期刊论文 , 2020, 卷号: 368, 期号: 6489 作者: Zhang L.; Lin D.; Sun X.; Curth U.; Drosten C.; Sauerhering L.; Becker S.; Rox K.; Hilgenfeld R. 收藏  |  浏览/下载:29/0  |  提交时间:2020/07/28 alanine alpha ketoamide inhibitor antivirus agent isoleucine leucine proteinase Severe acute respiratory syndrome coronavirus 2 main protease threonine unclassified drug crystal structure drug enzyme enzyme activity inhibitor reaction kinetics amino acid sequence animal cell animal experiment animal tissue antiviral activity Article catalysis catalytic efficiency controlled study crystal structure dimerization dissociation constant drug clearance drug design drug distribution drug half life drug potency drug protein binding drug solubility drug structure EC50 enzyme inhibition human human cell hydrogen bond hydrophobicity IC50 maximum concentration mean residence time metabolic stability mouse nonhuman priority journal protein structure RNA replication SARS coronavirus Severe acute respiratory syndrome coronavirus 2 viral tropism virus inhibition Coronavirus SARS coronavirus |
| Enhanced sustainable green revolution yield via nitrogen-responsive chromatin modulation in rice 期刊论文 , 2020, 卷号: 367, 期号: 6478 作者: Wu K.; Wang S.; Song W.; Zhang J.; Wang Y.; Liu Q.; Yu J.; Ye Y.; Li S.; Chen J.; Zhao Y.; Wang J.; Wu X.; Wang M.; Zhang Y.; Liu B.; Wu Y.; Harberd N.P.; Fu X. 收藏  |  浏览/下载:32/0  |  提交时间:2020/07/28 DELLA protein gibberellin gibberellin insensitive dwarf1 histone H3 polycomb repressive complex 2 receptor transcription factor unclassified drug alternative agriculture chromosome gene expression genetic engineering green revolution inhibition molecular analysis nitrogen nutrient use efficiency protein rice agriculture allele Article chromatin immunoprecipitation controlled study D14 gene gene mutation genetic screening genetic transcription grain yield green revolution histone modification modulation ngr5 gene nitrogen availability nitrogen responsive chromatin modulation nonhuman OsSPL14 gene plant gene polymerase chain reaction priority journal protein protein interaction rice RNA sequencing varietas |
| Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding 期刊论文 , 2020, 卷号: 368, 期号: 6489 作者: Yu J.; Gimenez L.E.; Hernandez C.C.; Wu Y.; Wein A.H.; Han G.W.; McClary K.; Mittal S.R.; Burdsall K.; Stauch B.; Wu L.; Stevens S.N.; Peisley A.; Williams S.Y.; Chen V.; Millhauser G.L.; Zhao S.; Cone R.D.; Stevens R.C. 收藏  |  浏览/下载:29/0  |  提交时间:2020/07/28 alpha intermedin calcium ion cyclic AMP G protein coupled receptor heterotrimeric guanine nucleotide binding protein inwardly rectifying potassium channel inwardly rectifying potassium channel subunit Kir7.1 melanocortin 4 receptor n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide] unclassified drug calcium G protein coupled receptor intermedin inwardly rectifying potassium channel Kir7.1 channel ligand melanocortin 4 receptor n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide] protein binding calcium chemical binding homeostasis hormone ligand obesity peptide protein Article binding affinity complex formation crystallization drug structure extracellular calcium human ligand binding priority journal protein structure receptor blocking signal transduction chemistry genetics mutation protein multimerization protein secondary structure X ray crystallography Calcium Crystallography, X-Ray Cyclic AMP Humans Ligands Melanocyte-Stimulating Hormones Mutation Potassium Channels, Inwardly Rectifying Protein Binding Protein Multimerization Protein Structure, Secondary Receptor, Melanocortin, Type 4 Receptors, G-Protein-Coupled Signal Transduction |
| Aminostratigraphical test of the East European Mammal Zonation for the late Neogene and Quaternary 期刊论文 Quaternary Science Reviews, 2020, 卷号: 245 作者: Tesakov A.S.; Frolov P.D.; Titov V.V.; Dickinson M.; Meijer T.; Parfitt S.A.; Preece R.C.; Penkman K.E.H. 收藏  |  浏览/下载:11/0  |  提交时间:2020/11/23 |
| Hygroscopic properties and compositional evolution of internally mixed sodium nitrate-amino acid aerosols 期刊论文 Atmospheric Environment, 2020, 卷号: 242 作者: Guo Y.; Wang N.; Pang S.; Zhang Y. 收藏  |  浏览/下载:23/0  |  提交时间:2020/11/23 |