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期刊论文 [4]
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2020 [4]
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英语 [4]
来源机构
Science [4]
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Structure of the RNA-dependent RNA polymerase from COVID-19 virus
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Gao Y.
;
Yan L.
;
Huang Y.
;
Liu F.
;
Zhao Y.
;
Cao L.
;
Wang T.
;
Sun Q.
;
Ming Z.
;
Zhang L.
;
Ge J.
;
Zheng L.
;
Zhang Y.
;
Wang H.
;
Zhu Y.
;
Zhu C.
;
Hu T.
;
Hua T.
;
Zhang B.
;
Yang X.
;
Li J.
;
Yang H.
;
Liu Z.
;
Xu W.
;
Guddat L.W.
;
Wang Q.
;
Lou Z.
;
Rao Z.
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/28
comparative study
drug
electron microscopy
enzyme
enzyme activity
RNA
virus
Coronavirus
SARS coronavirus
adenosine phosphate
alanine
antivirus agent
NSP7 protein, SARS-CoV-2
NSP8 protein, SARS-CoV-2
remdesivir
RNA directed RNA polymerase
RNA-dependent RNA polymerase, coronavirus
viral protein
beta sheet
Betacoronavirus
chemistry
cryoelectron microscopy
drug design
enzyme active site
enzymology
metabolism
molecular model
protein domain
ultrastructure
Adenosine Monophosphate
Alanine
Antiviral Agents
Betacoronavirus
Catalytic Domain
Cryoelectron Microscopy
Drug Design
Models, Molecular
Protein Conformation, beta-Strand
Protein Domains
RNA Replicase
Viral Nonstructural Proteins
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved a-ketoamide inhibitors
期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:
Zhang L.
;
Lin D.
;
Sun X.
;
Curth U.
;
Drosten C.
;
Sauerhering L.
;
Becker S.
;
Rox K.
;
Hilgenfeld R.
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/28
alanine
alpha ketoamide inhibitor
antivirus agent
isoleucine
leucine
proteinase
Severe acute respiratory syndrome coronavirus 2 main protease
threonine
unclassified drug
crystal structure
drug
enzyme
enzyme activity
inhibitor
reaction kinetics
amino acid sequence
animal cell
animal experiment
animal tissue
antiviral activity
Article
catalysis
catalytic efficiency
controlled study
crystal structure
dimerization
dissociation constant
drug clearance
drug design
drug distribution
drug half life
drug potency
drug protein binding
drug solubility
drug structure
EC50
enzyme inhibition
human
human cell
hydrogen bond
hydrophobicity
IC50
maximum concentration
mean residence time
metabolic stability
mouse
nonhuman
priority journal
protein structure
RNA replication
SARS coronavirus
Severe acute respiratory syndrome coronavirus 2
viral tropism
virus inhibition
Coronavirus
SARS coronavirus
Enhanced sustainable green revolution yield via nitrogen-responsive chromatin modulation in rice
期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:
Wu K.
;
Wang S.
;
Song W.
;
Zhang J.
;
Wang Y.
;
Liu Q.
;
Yu J.
;
Ye Y.
;
Li S.
;
Chen J.
;
Zhao Y.
;
Wang J.
;
Wu X.
;
Wang M.
;
Zhang Y.
;
Liu B.
;
Wu Y.
;
Harberd N.P.
;
Fu X.
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/28
DELLA protein
gibberellin
gibberellin insensitive dwarf1
histone H3
polycomb repressive complex 2
receptor
transcription factor
unclassified drug
alternative agriculture
chromosome
gene expression
genetic engineering
green revolution
inhibition
molecular analysis
nitrogen
nutrient use efficiency
protein
rice
agriculture
allele
Article
chromatin immunoprecipitation
controlled study
D14 gene
gene mutation
genetic screening
genetic transcription
grain yield
green revolution
histone modification
modulation
ngr5 gene
nitrogen availability
nitrogen responsive chromatin modulation
nonhuman
OsSPL14 gene
plant gene
polymerase chain reaction
priority journal
protein protein interaction
rice
RNA sequencing
varietas
Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding
期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:
Yu J.
;
Gimenez L.E.
;
Hernandez C.C.
;
Wu Y.
;
Wein A.H.
;
Han G.W.
;
McClary K.
;
Mittal S.R.
;
Burdsall K.
;
Stauch B.
;
Wu L.
;
Stevens S.N.
;
Peisley A.
;
Williams S.Y.
;
Chen V.
;
Millhauser G.L.
;
Zhao S.
;
Cone R.D.
;
Stevens R.C.
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/28
alpha intermedin
calcium ion
cyclic AMP
G protein coupled receptor
heterotrimeric guanine nucleotide binding protein
inwardly rectifying potassium channel
inwardly rectifying potassium channel subunit Kir7.1
melanocortin 4 receptor
n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide]
unclassified drug
calcium
G protein coupled receptor
intermedin
inwardly rectifying potassium channel
Kir7.1 channel
ligand
melanocortin 4 receptor
n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide]
protein binding
calcium
chemical binding
homeostasis
hormone
ligand
obesity
peptide
protein
Article
binding affinity
complex formation
crystallization
drug structure
extracellular calcium
human
ligand binding
priority journal
protein structure
receptor blocking
signal transduction
chemistry
genetics
mutation
protein multimerization
protein secondary structure
X ray crystallography
Calcium
Crystallography, X-Ray
Cyclic AMP
Humans
Ligands
Melanocyte-Stimulating Hormones
Mutation
Potassium Channels, Inwardly Rectifying
Protein Binding
Protein Multimerization
Protein Structure, Secondary
Receptor, Melanocortin, Type 4
Receptors, G-Protein-Coupled
Signal Transduction