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作者
Yang H. [5]
Zhao Y. [4]
Gao Y. [3]
Li J. [3]
Rao Z. [3]
Yang X. [3]
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文献类型
期刊论文 [5]
发表日期
2020 [5]
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英语 [5]
来源机构
Science [5]
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来源机构:Science
作者:Yang H.
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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:
Dai W.
;
Zhang B.
;
Jiang X.-M.
;
Su H.
;
Li J.
;
Zhao Y.
;
Xie X.
;
Jin Z.
;
Peng J.
;
Liu F.
;
Li C.
;
Li Y.
;
Bai F.
;
Wang H.
;
Cheng X.
;
Cen X.
;
Hu S.
;
Yang X.
;
Wang J.
;
Liu X.
;
Xiao G.
;
Jiang H.
;
Rao Z.
;
Zhang L.-K.
;
Xu Y.
;
Yang H.
;
Liu H.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/28
aldehyde
antimicrobial activity
drug
enzyme activity
infectivity
inhibitor
reaction kinetics
viral disease
Coronavirus
SARS coronavirus
3C-like proteinase, Coronavirus
antivirus agent
cysteine proteinase
viral protein
animal
Betacoronavirus
chemical structure
chemistry
Chlorocebus aethiops
Coronavirus infection
dog
drug design
drug effect
enzyme active site
enzymology
female
human
male
mouse
pandemic
preclinical study
protein tertiary structure
Sprague Dawley rat
toxicity testing
Vero cell line
virus pneumonia
Animals
Antiviral Agents
Betacoronavirus
Catalytic Domain
Chlorocebus aethiops
Coronavirus Infections
Cysteine Endopeptidases
Dogs
Drug Design
Drug Evaluation, Preclinical
Female
Humans
Male
Mice
Molecular Structure
Pandemics
Pneumonia, Viral
Protein Structure, Tertiary
Rats, Sprague-Dawley
Toxicity Tests
Vero Cells
Viral Nonstructural Proteins
Structure of the RNA-dependent RNA polymerase from COVID-19 virus
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Gao Y.
;
Yan L.
;
Huang Y.
;
Liu F.
;
Zhao Y.
;
Cao L.
;
Wang T.
;
Sun Q.
;
Ming Z.
;
Zhang L.
;
Ge J.
;
Zheng L.
;
Zhang Y.
;
Wang H.
;
Zhu Y.
;
Zhu C.
;
Hu T.
;
Hua T.
;
Zhang B.
;
Yang X.
;
Li J.
;
Yang H.
;
Liu Z.
;
Xu W.
;
Guddat L.W.
;
Wang Q.
;
Lou Z.
;
Rao Z.
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2020/07/28
comparative study
drug
electron microscopy
enzyme
enzyme activity
RNA
virus
Coronavirus
SARS coronavirus
adenosine phosphate
alanine
antivirus agent
NSP7 protein, SARS-CoV-2
NSP8 protein, SARS-CoV-2
remdesivir
RNA directed RNA polymerase
RNA-dependent RNA polymerase, coronavirus
viral protein
beta sheet
Betacoronavirus
chemistry
cryoelectron microscopy
drug design
enzyme active site
enzymology
metabolism
molecular model
protein domain
ultrastructure
Adenosine Monophosphate
Alanine
Antiviral Agents
Betacoronavirus
Catalytic Domain
Cryoelectron Microscopy
Drug Design
Models, Molecular
Protein Conformation, beta-Strand
Protein Domains
RNA Replicase
Viral Nonstructural Proteins
Visualizing H2O molecules reacting at TiO2 active sites with transmission electron microscopy
期刊论文
, 2020, 卷号: 367, 期号: 6476
作者:
Yuan W.
;
Zhu B.
;
Li X.-Y.
;
Hansen T.W.
;
Ou Y.
;
Fang K.
;
Yang H.
;
Zhang Z.
;
Wagner J.B.
;
Gao Y.
;
Wang Y.
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/28
nanocrystal
oxygen
titanium dioxide
water
anatase
catalysis
catalyst
gas phase reaction
inorganic compound
reconstruction
transmission electron microscopy
adsorption
Article
catalyst
chemical modification
chemical reaction
chemical structure
density functional theory
dissociation
electron beam
heating
molecular stability
priority journal
thermodynamics
transmission electron microscopy
water vapor
Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2
期刊论文
, 2020, 卷号: 368, 期号: 6494
作者:
Shi J.
;
Wen Z.
;
Zhong G.
;
Yang H.
;
Wang C.
;
Huang B.
;
Liu R.
;
He X.
;
Shuai L.
;
Sun Z.
;
Zhao Y.
;
Liu P.
;
Liang L.
;
Cui P.
;
Wang J.
;
Zhang X.
;
Guan Y.
;
Tan W.
;
Wu G.
;
Chen H.
;
Bu Z.
;
Bu Z.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/28
bat
canid
disease control
disease transmission
felid
global perspective
infectious disease
poultry
severe acute respiratory syndrome
viral disease
virus
China
Hubei
Wuhan
Anas
Animalia
Canis familiaris
Coronavirus
Gallus gallus
Mustela
SARS coronavirus
Suidae
virus antibody
virus RNA
animal
Betacoronavirus
blood
cat
chicken
Coronavirus infection
disease model
disease predisposition
dog
domestic animal
duck
feces
female
immunology
isolation and purification
male
Mustela putorius furo
pandemic
physiology
pig
respiratory system
species difference
virology
virus attachment
virus pneumonia
virus replication
Animals
Animals, Domestic
Antibodies, Viral
Betacoronavirus
Cats
Chickens
Coronavirus Infections
Disease Models, Animal
Disease Susceptibility
Dogs
Ducks
Feces
Female
Ferrets
Male
Pandemics
Pneumonia, Viral
Respiratory System
RNA, Viral
Species Specificity
Sus scrofa
Virus Attachment
Virus Replication
Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol
期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:
Zhang L.
;
Zhao Y.
;
Gao Y.
;
Wu L.
;
Gao R.
;
Zhang Q.
;
Wang Y.
;
Wu C.
;
Wu F.
;
Gurcha S.S.
;
Veerapen N.
;
Batt S.M.
;
Zhao W.
;
Qin L.
;
Yang X.
;
Wang M.
;
Zhu Y.
;
Zhang B.
;
Bi L.
;
Zhang X.
;
Yang H.
;
Guddat L.W.
;
Xu W.
;
Wang Q.
;
Li J.
;
Besra G.S.
;
Rao Z.
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/28
biochemistry
cell component
chemical binding
detection method
drug
drug resistance
enzyme
enzyme activity
inhibition
mutation
Mycobacterium tuberculosis
arabinosyltransferase
ethambutol
glycosyltransferase
tuberculostatic agent
cell wall
chemistry
cryoelectron microscopy
enzymology
multidrug resistance
Mycobacterium tuberculosis
protein conformation
Antitubercular Agents
Cell Wall
Cryoelectron Microscopy
Drug Resistance, Multiple, Bacterial
Ethambutol
Mycobacterium tuberculosis
Pentosyltransferases
Protein Conformation