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| Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Walton R.T.; Christie K.A.; Whittaker M.N.; Kleinstiver B.P.
  收藏 | 浏览/下载：18/0 | 提交时间：2020/07/28
adenine adenosine CRISPR associated endonuclease Cas9 cytosine guanosine SpG protein SpRY nuclease thymine unclassified drug Cas9 endonuclease Streptococcus pyogenes bacterium enzyme activity genetic engineering genetic variation genome Article CRISPR-CAS9 system DNA sequence enzyme activity gene editing gene targeting genetic variability human mutagenesis nonhuman priority journal protein engineering protein motif protein structure protospacer adjacent motif Streptococcus pyogenes chemistry CRISPR Cas system enzyme specificity gene editing gene targeting genetic predisposition genetics HEK293 cell line procedures protein domain Streptococcus pyogenes CRISPR-Associated Protein 9 CRISPR-Cas Systems Gene Editing Gene Targeting Genetic Predisposition to Disease HEK293 Cells Humans Mutagenesis Protein Domains Substrate Specificity |
| Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者: Hoffman D.P.; Shtengel G.; Xu C.S.; Campbell K.R.; Freeman M.; Wang L.; Milkie D.E.; Pasolli H.A.; Iyer N.; Bogovic J.A.; Stabley D.R.; Shirinifard A.; Pang S.; Peale D.; Schaefer K.; Pomp W.; Chang C.-L.; Lippincott-Schwartz J.; Kirchhausen T.; Solecki D.J.; Betzig E.; Hess H.F.
收藏 | 浏览/下载：40/0 | 提交时间：2020/07/28
cell compartmentalization cryopreservation electron microscopy image resolution protein three-dimensional modeling ultrastructure article chromatin electron microscopy endoplasmic reticulum genetic transcription human cell mammal cell nerve cell culture protein domain ultrastructure whole cell workflow animal cell adhesion cells Chlorocebus aethiops cryoelectron microscopy CV-1 cell line fluorescence microscopy freezing HeLa cell line human mouse procedures three-dimensional imaging tumor cell line ultrastructure Mammalia Animals Cell Adhesion Cell Line, Tumor Cells Chlorocebus aethiops COS Cells Cryoelectron Microscopy Freezing HeLa Cells Humans Imaging, Three-Dimensional Mice Microscopy, Fluorescence |
| Single-cell transcriptional diversity is a hallmark of developmental potential 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者: Gulati G.S.; Sikandar S.S.; Wesche D.J.; Manjunath A.; Bharadwaj A.; Berger M.J.; Ilagan F.; Kuo A.H.; Hsieh R.W.; Cai S.; Zabala M.; Scheeren F.A.; Lobo N.A.; Qian D.; Yu F.B.; Dirbas F.M.; Clarke M.F.; Newman A.M.
收藏 | 浏览/下载：37/0 | 提交时间：2020/07/28
cell cell component developmental biology experimental study genetic analysis tumor Article breast cancer breast carcinogenesis carcinogenesis cell differentiation computer model embryonic stem cell gene expression genetic code genetic variability human in vivo study nonhuman phenotype priority journal scoring system single cell RNA seq upregulation |
| The genetic architecture of the human cerebral cortex 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者: Grasby K.L.; Jahanshad N.; Painter J.N.; Colodro-Conde L.; Bralten J.; Hibar D.P.; Lind P.A.; Pizzagalli F.; Ching C.R.K.; McMahon M.A.B.; Shatokhina N.; Zsembik L.C.P.; Thomopoulos S.I.; Zhu A.H.; Strike L.T.; Agartz I.; Alhusaini S.; Almeida M.A.A.; Alnæs D.; Amlien I.K.; Andersson M.; Ard T.; Armstrong N.J.; Ashley-Koch A.; Atkins J.R.; Bernard M.; Brouwer R.M.; Buimer E.E.L.; Bülow R.; Bürger C.; Cannon D.M.; Chakravarty M.; Chen Q.; Cheung J.W.; Couvy-Duchesne B.; Dale A.M.; Dalvie S.; de Araujo T.K.; de Zubicaray G.I.; de Zwarte S.M.C.; den Braber A.; Doan N.T.; Dohm K.; Ehrlich S.; Engelbrecht H.-R.; Erk S.; Fan C.C.; Fedko I.O.; Foley S.F.; Ford J.M.; Fukunaga M.; Garrett M.E.; Ge T.; Giddaluru S.; Goldman A.L.; Green M.J.; Groenewold N.A.; Grotegerd D.; Gurholt T.P.; Gutman B.A.; Hansell N.K.; Harris M.A.; Harrison M.B.; Haswell C.C.; Hauser M.; Herms S.; Heslenfeld D.J.; Ho N.F.; Hoehn D.; Hoffmann P.; Holleran L.; Hoogman M.; Hottenga J.-J.; Ikeda M.; Janowitz D.; Jansen I.E.; Jia T.; Jockwitz C.; Kanai R.; Karama S.; Kasperaviciute D.; Kaufmann T.; Kelly S.; Kikuchi M.; Klein M.; Knapp M.; Knodt A.R.; Krämer B.; Lam M.; Lancaster T.M.; Lee P.H.; Lett T.A.; Lewis L.B.; Lopes-Cendes I.; Luciano M.; Macciardi F.; Marquand A.F.; Mathias S.R.; Melzer T.R.; Milaneschi Y.; Mirza-Schreiber N.; Moreira J.C.V.; Mühleisen T.W.; Müller-Myhsok B.; Najt P.; Nakahara S.; Nho K.; Olde Loohuis L.M.; Orfanos D.P.; Pearson J.F.; Pitcher T.L.; Pütz B.; Quidé Y.; Ragothaman A.; Rashid F.M.; Reay W.R.; Redlich R.; Reinbold C.S.; Repple J.; Richard G.; Riedel B.C.; Risacher S.L.; Rocha C.S.; Mota N.R.; Salminen L.; Saremi A.; Saykin A.J.; Schlag F.; Schmaal L.; Schofield P.R.; Secolin R.; Shapland C.Y.; Shen L.; Shin J.; Shumskaya E.; Sønderby I.E.; Sprooten E.; Tansey K.E.; Teumer A.; Thalamuthu A.; Tordesillas-Gutiérrez D.; Turner J.A.; Uhlmann A.; Vallerga C.L.; van der Meer D.; van Donkelaar M.M.J.; van Eijk L.; van Erp T.G.M.; van Haren N.E.M.; van Rooij D.; van Tol M.-J.; Veldink J.H.; Verhoef E.; Walton E.; Wang M.; Wang Y.; Wardlaw J.M.; Wen W.; Westlye L.T.; Whelan C.D.; Witt S.H.; Wittfeld K.; Wolf C.; Wolfers T.; Wu J.Q.; Yasuda C.L.; Zaremba D.; Zhang Z.; Zwiers M.P.; Artiges E.; Assareh A.A.; Ayesa-Arriola R.; Belger A.; Brandt C.L.; Brown G.G.; Cichon S.; Curran J.E.; Davies G.E.; Degenhardt F.; Dennis M.F.; Dietsche B.; Djurovic S.; Doherty C.P.; Espiritu R.; Garijo D.; Gil Y.; Gowland P.A.; Green R.C.; Häusler A.N.; Heindel W.; Ho B.-C.; Hoffmann W.U.; Holsboer F.; Homuth G.; Hosten N.; Jack C.R.; Jang M.; Jansen A.; Kimbrel N.A.; Kolskår K.; Koops S.; Krug A.; Lim K.O.; Luykx J.J.; Mathalon D.H.; Mather K.A.; Mattay V.S.; Matthews S.; van Son J.M.; McEwen S.C.; Melle I.; Morris D.W.; Mueller B.A.; Nauck M.; Nordvik J.E.; Nöthen M.M.; O'Leary D.S.; Opel N.; Martinot M.-L.P.; Bruce Pike G.; Preda A.; Quinlan E.B.; Rasser P.E.; Ratnakar V.; Reppermund S.; Steen V.M.; Tooney P.A.; Torres F.R.; Veltman D.J.; Voyvodic J.T.; Whelan R.; White T.; Yamamori H.; Adams H.H.H.; Bis J.C.; Debette S.; Decarli C.; Fornage M.; Gudnason V.; Hofer E.; Arfan Ikram M.; Launer L.; Longstreth W.T.; Lopez O.L.; Mazoyer B.; Mosley T.H.; Roshchupkin G.V.; Satizabal C.L.; Schmidt R.; Seshadri S.; Yang Q.; Alvim M.K.M.; Ames D.; Anderson T.J.; Andreassen O.A.; Arias-Vasquez A.; Bastin M.E.; Baune B.T.; Beckham J.C.; Blangero J.; Boomsma D.I.; Brodaty H.; Brunner H.G.; Buckner R.L.; Buitelaar J.K.; Bustillo J.R.; Cahn W.; Cairns M.J.; Calhoun V.; Carr V.J.; Caseras X.; Caspers S.; Cavalleri G.L.; Cendes F.; Corvin A.; Crespo-Facorro B.; Dalrymple-Alford J.C.; Dannlowski U.; de Geus E.J.C.; Deary I.J.; Delanty N.; Depondt C.; Desrivières S.; Donohoe G.; Espeseth T.; Fernández G.; Fisher S.E.; Flor H.; Forstner A.J.; Francks C.; Franke B.; Glahn D.C.; Gollub R.L.; Grabe H.J.; Gruber O.; Håberg A.K.; Hariri A.R.; Hartman C.A.; Hashimoto R.; Heinz A.; Henskens F.A.; Hillegers M.H.J.; Hoekstra P.J.; Holmes A.J.; Elliot Hong L.; Hopkins W.D.; Hulshoff Pol H.E.; Jernigan T.L.; Jönsson E.G.; Kahn R.S.; Kennedy M.A.; Kircher T.T.J.; Kochunov P.; Kwok J.B.J.; Le Hellard S.; Loughland C.M.; Martin N.G.; Martinot J.-L.; McDonald C.; McMahon K.L.; Meyer-Lindenberg A.; Michie P.T.; Morey R.A.; Mowry B.; Nyberg L.; Oosterlaan J.; Ophoff R.A.; Pantelis C.; Paus T.; Pausova Z.; Penninx B.W.J.H.; Polderman T.J.C.; Posthuma D.; Rietschel M.; Roffman J.L.; Rowland L.M.; Sachdev P.S.; Sämann P.G.; Schall U.; Schumann G.; Scott R.J.; Sim K.; Sisodiya S.M.; Smoller J.W.; Sommer I.E.; Pourcain B.S.; Stein D.J.; Toga A.W.; Trollor J.N.; van der Wee N.J.A.; van't Ent D.; Völzke H.; Walter H.; Weber B.; Weinberger D.R.; Wright M.J.; Zhou J.; Stein J.L.; Thompson P.M.; Medland S.E.; Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group
收藏 | 浏览/下载：47/0 | 提交时间：2020/07/28
brain genetic analysis meta-analysis resonance signaling surface area Article bioinformatics brain cortex brain function brain region brain tissue cortical thickness (brain) educational status evidence based medicine gene control gene locus genetic association genetic correlation genetic variability genome-wide association study human human genetics priority journal surface area tissue structure Wnt signaling anatomy and histology attention deficit disorder brain cortex brain mapping cognition genetic variation genetics meta analysis nuclear magnetic resonance imaging organ size Parkinson disease Attention Deficit Disorder with Hyperactivity Brain Mapping Cerebral Cortex Cognition Genetic Loci Genetic Variation Genome-Wide Association Study Humans Magnetic Resonance Imaging Organ Size Parkinson Disease |
| Large contribution from anthropogenic warming to an emerging North American megadrought 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Williams A.P.; Cook E.R.; Smerdon J.E.; Cook B.I.; Abatzoglou J.T.; Bolles K.; Baek S.H.; Badger A.M.; Livneh B.
收藏 | 浏览/下载：29/0 | 提交时间：2020/07/28
anthropogenic effect drought global warming hydrological modeling reconstruction tree ring twenty first century article climate change drought humidity Middle Ages North America precipitation soil moisture summer warming comparative study drought greenhouse effect history human activities hydrology soil theoretical model North America Droughts Global Warming History, 21st Century History, Medieval Human Activities Hydrology Models, Theoretical North America Soil |
| The Sun is less active than other solar-like stars 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者: Reinhold T.; Shapiro A.I.; Solanki S.K.; Montet B.T.; Krivova N.A.; Cameron R.H.; Amazo-Gómez E.M.
收藏 | 浏览/下载：29/0 | 提交时间：2020/07/28
astrophysics cosmology Earth rotation magnetic field photometer solar radiation solar system Article astronomy chemical parameters gravity metallicity meteorological phenomena near solar effective temperature near solar rotation period photometry priority journal solar variability stellar variability sun surface gravity temperature |
| The evolutionary dynamics and fitness landscape of clonal hematopoiesis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者: Watson C.J.; Papula A.L.; Poon G.Y.P.; Wong W.H.; Young A.L.; Druley T.E.; Fisher D.S.; Blundell J.R.
收藏 | 浏览/下载：21/0 | 提交时间：2020/07/28
DNA methyltransferase 3A blood cancer evolutionary biology fitness gene expression genetic drift hematology mutation pathogenicity acute myeloid leukemia age distribution allele Article cancer risk cell expansion cell population clonal hematopoiesis epigenetics gene mutation genetic variability hematological parameters hematopoiesis hematopoietic stem cell human molecular evolution mutational analysis nonhuman priority journal single nucleotide polymorphism somatic mutation stem cell self-renewal |
| Contemporaneity of australopithecus, paranthropus, and early homo erectus in South Africa 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者: Herries A.I.R.; Martin J.M.; Leece A.B.; Adams J.W.; Boschian G.; Joannes-Boyau R.; Edwards T.R.; Mallett T.; Massey J.; Murszewski A.; Neubauer S.; Pickering R.; Strait D.S.; Armstrong B.J.; Baker S.; Caruana M.V.; Denham T.; Hellstrom J.; Moggi-Cecchi J.; Mokobane S.; Penzo-Kajewski P.; Rovinsky D.S.; Schwartz G.T.; Stammers R.C.; Wilson C.; Woodhead J.; Menter C.
收藏 | 浏览/下载：38/0 | 提交时间：2020/07/28
climate variation cranium dispersal endemism extinction fossil record hominid human evolution taxonomy article Australopithecus Homo erectus nonhuman Paranthropus skull South Africa Drimolen Gauteng South Africa Australopithecus Crania Homo erectus Paranthropus Paranthropus robustus |
| Phase separation provides a mechanism to reduce noise in cells 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者: Klosin A.; Oltsch F.; Harmon T.; Honigmann A.; Jülicher F.; Hyman A.A.; Zechner C.
收藏 | 浏览/下载：30/0 | 提交时间：2020/07/28
cell concentration (composition) noise phase transition protein separation article controlled study mammal cell noise reduction phase separation physical model signal processing theoretical study Mammalia |
| Genetics of schizophrenia in the South African Xhosa 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者: Gulsuner S.; Stein D.J.; Susser E.S.; Sibeko G.; Pretorius A.; Walsh T.; Majara L.; Mndini M.M.; Mqulwana S.G.; Ntola O.A.; Casadei S.; Ngqengelele L.L.; Korchina V.; Van Der Merwe C.; Malan M.; Fader K.M.; Feng M.; Willoughby E.; Muzny D.; Baldinger A.; Andrews H.F.; Gur R.C.; Gibbs R.A.; Zingela Z.; Nagdee M.; Ramesar R.S.; King M.-C.; McClellan J.M.
收藏 | 浏览/下载：34/0 | 提交时间：2020/07/28
4 aminobutyric acid dopamine glutamine genetic analysis genetic variation genome genomics mutagenicity mutation Article connectome controlled study gene mutation genetic variability genetics human major clinical study nerve cell plasticity priority journal schizophrenia South African Xhosa (people) South Africa |
