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期刊论文 [7]
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2020 [7]
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英语 [7]
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Science [7]
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Computing cancer's weak spots
期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:
Khamsi R.
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2020/07/28
ruxolitinib
STAT3 protein
antineoplastic agent
transcription factor
algorithm
cancer
computer simulation
disease treatment
drug development
medicine
Article
cancer cell
cancer radiotherapy
enzyme inhibition
gene activity
gene expression regulation
gene interaction
gene mutation
gene repression
gene targeting
human
laboratory test
malignant neoplasm
molecular dynamics
nonhuman
oncologist
priority journal
RNA sequencing
algorithm
genetics
mutation
neoplasm
personalized medicine
procedures
systems biology
Algorithms
Antineoplastic Agents
Humans
Mutation
Neoplasms
Precision Medicine
Systems Biology
Transcription Factors
Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b
期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:
Weber C.
;
Zhou Y.
;
Lee J.G.
;
Looger L.L.
;
Qian G.
;
Ge C.
;
Capel B.
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/28
STAT3 protein
calcium
histone demethylase
STAT3 protein
embryonic development
gene expression
sex determination
temperature effect
turtle
animal cell
animal experiment
Article
binding site
calcium transport
cell activation
chromatin immunoprecipitation
controlled study
dimerization
Dmrt1 gene
embryo
embryo development
environmental temperature
epigenetic repression
female
gene
gene activation
gene interaction
gene targeting
genetic transcription
gonad
high temperature
immunofluorescence test
Kdm6b gene
male
nonhuman
priority journal
protein phosphorylation
real time polymerase chain reaction
sex determination
signal transduction
temperature dependence
thermoregulation
transcription regulation
upregulation
Western blotting
animal
embryology
gene expression regulation
genetics
metabolism
phosphorylation
sex determination process
temperature
turtle
Reptilia
Trachemys scripta
Trachemys scripta elegans
Animals
Calcium
Female
Gene Expression Regulation, Developmental
Jumonji Domain-Containing Histone Demethylases
Male
Phosphorylation
Sex Determination Processes
STAT3 Transcription Factor
Temperature
Transcription, Genetic
Turtles
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants
期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:
Walton R.T.
;
Christie K.A.
;
Whittaker M.N.
;
Kleinstiver B.P.
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/28
adenine
adenosine
CRISPR associated endonuclease Cas9
cytosine
guanosine
SpG protein
SpRY nuclease
thymine
unclassified drug
Cas9 endonuclease Streptococcus pyogenes
bacterium
enzyme activity
genetic engineering
genetic variation
genome
Article
CRISPR-CAS9 system
DNA sequence
enzyme activity
gene editing
gene targeting
genetic variability
human
mutagenesis
nonhuman
priority journal
protein engineering
protein motif
protein structure
protospacer adjacent motif
Streptococcus pyogenes
chemistry
CRISPR Cas system
enzyme specificity
gene editing
gene targeting
genetic predisposition
genetics
HEK293 cell line
procedures
protein domain
Streptococcus pyogenes
CRISPR-Associated Protein 9
CRISPR-Cas Systems
Gene Editing
Gene Targeting
Genetic Predisposition to Disease
HEK293 Cells
Humans
Mutagenesis
Protein Domains
Substrate Specificity
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:
Yuan M.
;
Wu N.C.
;
Zhu X.
;
Lee C.-C.D.
;
So R.T.Y.
;
Lv H.
;
Mok C.K.P.
;
Wilson I.A.
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/28
angiotensin converting enzyme 2
epitope
neutralizing antibody
virus hemagglutinin
virus spike protein
angiotensin converting enzyme 2
coronavirus receptors
coronavirus spike glycoprotein
dipeptidyl carboxypeptidase
epitope
neutralizing antibody
spike glycoprotein, SARS-CoV
spike protein, SARS-CoV-2
virus antibody
virus antigen
virus receptor
antibody
antigen
chemical binding
crystal structure
protein
respiratory disease
viral disease
virus
amino terminal sequence
antibody isolation
antigen binding
antigenicity
Article
binding affinity
binding site
conservation biology
controlled study
coronavirus disease 2019
cross reaction
cryoelectron microscopy
crystal structure
enzyme linked immunosorbent assay
epidemic
glycosylation
human
hydrophobicity
immune response
in vitro study
in vivo study
light chain
nonhuman
priority journal
protein conformation
protein domain
protein interaction
protein localization
protein structure
protein targeting
receptor binding
SARS coronavirus
Severe acute respiratory syndrome coronavirus 2
amino acid sequence
antibody affinity
Betacoronavirus
binding site
chemistry
immunology
metabolism
molecular model
SARS coronavirus
X ray crystallography
Coronavirus
SARS coronavirus
Amino Acid Sequence
Antibodies, Neutralizing
Antibodies, Viral
Antibody Affinity
Antigens, Viral
Betacoronavirus
Binding Sites
Cross Reactions
Crystallography, X-Ray
Epitopes
Models, Molecular
Peptidyl-Dipeptidase A
Protein Conformation
Protein Domains
Protein Interaction Domains and Motifs
Receptors, Virus
SARS Virus
Spike Glycoprotein, Coronavirus
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation
期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:
Gilan O.
;
Rioja I.
;
Knezevic K.
;
Bell M.J.
;
Yeung M.M.
;
Harker N.R.
;
Lam E.Y.N.
;
Chung C.
;
Bamborough P.
;
Petretich M.
;
Urh M.
;
Atkinson S.J.
;
Bassil A.K.
;
Roberts E.J.
;
Vassiliadis D.
;
Burr M.L.
;
Preston A.G.S.
;
Wellaway C.
;
Werner T.
;
Gray J.R.
;
Michon A.-M.
;
Gobbetti T.
;
Kumar V.
;
Soden P.E.
;
Haynes A.
;
Vappiani J.
;
Tough D.F.
;
Taylor S.
;
Dawson S.-J.
;
Bantscheff M.
;
Lindon M.
;
Drewes G.
;
Demont E.H.
;
Daniels D.L.
;
Grandi P.
;
Prinjha R.K.
;
Dawson M.A.
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/28
7 (3,5 dimethyl 4 isoxazolyl) 1,3 dihydro 8 methoxy 1 [1 (2 pyridinyl)ethyl] 2h imidazo[4,5 c]quinolin 2 one
apremilast
bromodomain and extraterminal domain protein 1
bromodomain and extraterminal domain protein 2
bromodomain inhibitor
gsk 046
gsk 620
gsk 778
transcription factor
unclassified drug
cancer
drug
gene expression
immune response
inhibitor
physiological response
acute myeloid leukemia
animal experiment
animal model
animal tissue
antibody response
antineoplastic activity
antiproliferative activity
apoptosis
Article
binding affinity
controlled study
crystal structure
drug design
drug efficacy
drug protein binding
drug selectivity
drug specificity
drug structure
drug targeting
gene expression
high throughput screening
human
human cell
IC50
immunomodulation
in vivo study
inflammation
K-562 cell line
malignant neoplasm
MDA-MB-453 cell line
MOLM-13 cell line
mouse
nonhuman
priority journal
psoriasis
Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab
期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:
Rougé L.
;
Chiang N.
;
Steffek M.
;
Kugel C.
;
Croll T.I.
;
Tam C.
;
Estevez A.
;
Arthur C.P.
;
Koth C.M.
;
Ciferri C.
;
Kraft E.
;
Payandeh J.
;
Nakamura G.
;
Koerber J.T.
;
Rohou A.
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/28
CD20 antigen
dimer
epitope
Fc receptor
immunoglobulin F(ab) fragment
obinutuzumab
ocrelizumab
ofatumumab
rituximab
tositumomab i 131
antibody
antigen
cell
chemical binding
composite
gene expression
genetic marker
protein
amino acid sequence
antibody dependent cellular cytotoxicity
antigen antibody complex
antigen binding
antigen structure
Article
cell death
cell surface
chemical bond
complement dependent cytotoxicity
drug protein binding
drug targeting
electron microscopy
human
humoral immune deficiency
insect cell
lipid raft
malignant neoplasm
molecular recognition
multiple sclerosis
nonhuman
phagocytosis
priority journal
protein cross linking
protein interaction
stoichiometry
surface plasmon resonance
Next-generation epigenetic inhibitors
期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:
Filippakopoulos P.
;
Knapp S.
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/28
biological marker
bromodomain inhibitor
DNA
experiment
genetic analysis
inhibitor
Article
binding site
down regulation
gene expression
histone modification
human
nonhuman
pleiotropy
priority journal
protein domain
protein folding
protein interaction
protein processing
protein targeting
transcription elongation
transcription regulation