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| A general method to synthesize and sinter bulk ceramics in seconds 期刊论文
, 2020, 卷号: 368, 期号: 6490
作者: Wang C.; Ping W.; Bai Q.; Cui H.; Hensleigh R.; Wang R.; Brozena A.H.; Xu Z.; Dai J.; Pei Y.; Zheng C.; Pastel G.; Gao J.; Wang X.; Wang H.; Zhao J.-C.; Yang B.; Zheng X.; Luo J.; Mo Y.; Dunn B.; Hu L.
  收藏 | 浏览/下载：34/0 | 提交时间：2020/07/28
electrolyte ceramics chemical composition computer system electrolyte heating mechanical property radiative transfer sinter volatile element Article ceramics chemical structure high temperature procedures high throughput screening materials testing priority journal radiation solid state synthesis ultrafast high temperature sintering |
| Computing cancer's weak spots 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Khamsi R.
收藏 | 浏览/下载：46/0 | 提交时间：2020/07/28
ruxolitinib STAT3 protein antineoplastic agent transcription factor algorithm cancer computer simulation disease treatment drug development medicine Article cancer cell cancer radiotherapy enzyme inhibition gene activity gene expression regulation gene interaction gene mutation gene repression gene targeting human laboratory test malignant neoplasm molecular dynamics nonhuman oncologist priority journal RNA sequencing algorithm genetics mutation neoplasm personalized medicine procedures systems biology Algorithms Antineoplastic Agents Humans Mutation Neoplasms Precision Medicine Systems Biology Transcription Factors |
| Microenvironment mapping via Dexter energy transfer on immune cells 期刊论文
, 2020, 卷号: 367, 期号: 6482
作者: Geri J.B.; Oakley J.V.; Reyes-Robles T.; Wang T.; McCarver S.J.; White C.H.; Rodriguez-Rivera F.P.; Parker D.L.; Hett E.C.; Fadeyi O.O.; Oslund R.C.; MacMillan D.W.C.
收藏 | 浏览/下载：39/0 | 提交时间：2020/07/28
antibody conjugate carbene programmed death 1 ligand 1 methane programmed death 1 ligand 1 antibody catalysis catalyst cell component detection method enzyme enzyme activity protein antigen binding Article cell membrane energy transfer human immunocompetent cell immunological synapse lymphocyte photocatalysis priority journal protein analysis protein protein interaction tumor microenvironment catalysis chemistry energy transfer Jurkat cell line metabolism photochemistry procedures radiation response ultraviolet radiation B7-H1 Antigen Catalysis Cell Membrane Cellular Microenvironment Energy Transfer Humans Jurkat Cells Lymphocytes Methane Photochemical Processes Protein Interaction Mapping Protein Interaction Maps Ultraviolet Rays |
| De novo protein design enables the precise induction of RSV-neutralizing antibodies 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者: Sesterhenn F.; Yang C.; Bonet J.; Cramer J.T.; Wen X.; Wang Y.; Chiang C.-I.; Abriata L.A.; Kucharska I.; Castoro G.; Vollers S.S.; Galloux M.; Dheilly E.; Rosset S.; Corthésy P.; Georgeon S.; Villard M.; Richard C.-A.; Descamps D.; Delgado T.; Oricchio E.; Rameix-Welti M.-A.; Más V.; Ervin S.; Eléouët J.-F.; Riffault S.; Bates J.T.; Julien J.-P.; Li Y.; Jardetzky T.; Krey T.; Correia B.E.
收藏 | 浏览/下载：43/0 | 提交时间：2020/07/28
algorithm antibody design neutralization protein vaccine Mus Primates Respiratory syncytial virus Rice stripe virus epitope fusion protein nanobody neutralizing antibody respiratory syncytial virus vaccine biology biosynthesis chemistry human Human respiratory syncytial virus immunology procedures protein conformation protein engineering protein motif Amino Acid Motifs Antibodies, Neutralizing Computational Biology Humans Immunodominant Epitopes Protein Conformation Protein Engineering Recombinant Fusion Proteins Respiratory Syncytial Virus Vaccines Respiratory Syncytial Virus, Human Single-Domain Antibodies |
| Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Walton R.T.; Christie K.A.; Whittaker M.N.; Kleinstiver B.P.
收藏 | 浏览/下载：27/0 | 提交时间：2020/07/28
adenine adenosine CRISPR associated endonuclease Cas9 cytosine guanosine SpG protein SpRY nuclease thymine unclassified drug Cas9 endonuclease Streptococcus pyogenes bacterium enzyme activity genetic engineering genetic variation genome Article CRISPR-CAS9 system DNA sequence enzyme activity gene editing gene targeting genetic variability human mutagenesis nonhuman priority journal protein engineering protein motif protein structure protospacer adjacent motif Streptococcus pyogenes chemistry CRISPR Cas system enzyme specificity gene editing gene targeting genetic predisposition genetics HEK293 cell line procedures protein domain Streptococcus pyogenes CRISPR-Associated Protein 9 CRISPR-Cas Systems Gene Editing Gene Targeting Genetic Predisposition to Disease HEK293 Cells Humans Mutagenesis Protein Domains Substrate Specificity |
| Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Pareek V.; Tian H.; Winograd N.; Benkovic S.J.
收藏 | 浏览/下载：35/0 | 提交时间：2020/07/28
adenosine phosphate guanosine phosphate multienzyme complex nucleotide purine purine purine derivative cell experimental study imaging method mass spectrometry metabolism protein Article biochemistry enzyme assay gas cluster ion beam secondary ion mass spectrometry image analysis mass spectrometry metabolomics mitochondrion molecular imaging molecular probe priority journal purine synthesis reaction analysis single cell analysis biosynthesis fluorescence imaging HeLa cell line human metabolism metabolomics procedures secondary ion mass spectrometry HeLa Cells Humans Metabolomics Mitochondria Multienzyme Complexes Optical Imaging Purines Single-Cell Analysis Spectrometry, Mass, Secondary Ion |
| Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者: Hoffman D.P.; Shtengel G.; Xu C.S.; Campbell K.R.; Freeman M.; Wang L.; Milkie D.E.; Pasolli H.A.; Iyer N.; Bogovic J.A.; Stabley D.R.; Shirinifard A.; Pang S.; Peale D.; Schaefer K.; Pomp W.; Chang C.-L.; Lippincott-Schwartz J.; Kirchhausen T.; Solecki D.J.; Betzig E.; Hess H.F.
收藏 | 浏览/下载：50/0 | 提交时间：2020/07/28
cell compartmentalization cryopreservation electron microscopy image resolution protein three-dimensional modeling ultrastructure article chromatin electron microscopy endoplasmic reticulum genetic transcription human cell mammal cell nerve cell culture protein domain ultrastructure whole cell workflow animal cell adhesion cells Chlorocebus aethiops cryoelectron microscopy CV-1 cell line fluorescence microscopy freezing HeLa cell line human mouse procedures three-dimensional imaging tumor cell line ultrastructure Mammalia Animals Cell Adhesion Cell Line, Tumor Cells Chlorocebus aethiops COS Cells Cryoelectron Microscopy Freezing HeLa Cells Humans Imaging, Three-Dimensional Mice Microscopy, Fluorescence |
| Response to fire by a forest specialist in isolated montane forest 期刊论文
, 2020, 卷号: 462
作者: Mazzella M.N.; Koprowski J.L.
收藏 | 浏览/下载：36/0 | 提交时间：2020/07/28
Climate change Ecosystems Fire hazards Fires Landforms Noninvasive medical procedures Fire frequencies Fire suppression Forest ecosystem Montane forests Noninvasive methods San Bernardino flying squirrel Southern California Species management Forestry climate change ecological modeling forest ecosystem montane forest mortality mountain region rodent subspecies Cores Dillenia Ecosystems Edges Fires Forestry Models Mountains California Coast Ranges San Bernardino Mountains San Jacinto Mountains Glaucomys Glaucomys sabrinus californicus Pteromyini |
| Very fast CRISPR on demand 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Liu Y.; Zou R.S.; He S.; Nihongaki Y.; Li X.; Razavi S.; Wu B.; Ha T.
收藏 | 浏览/下载：23/0 | 提交时间：2020/07/28
Cas9 endonuclease Streptococcus pyogenes double strand break repair protein MRE11 H2AX protein, human histone MRE11 protein, human CRISPR Cas system DNA cleavage DNA repair double stranded DNA break fluorescence imaging gene editing genetics HEK293 cell line human light metabolism phosphorylation procedures radiation response single cell analysis CRISPR-Associated Protein 9 CRISPR-Cas Systems DNA Breaks, Double-Stranded DNA Cleavage DNA Repair Gene Editing HEK293 Cells Histones Humans Light MRE11 Homologue Protein Optical Imaging Phosphorylation Single-Cell Analysis |
| Disordered proteins follow diverse transition paths as they fold and bind to a partner 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Kim J.-Y.; Chung H.S.
收藏 | 浏览/下载：31/0 | 提交时间：2020/07/28
intrinsically disordered protein protein binding chemistry fluorescence resonance energy transfer procedures protein conformation protein folding single molecule imaging static electricity Fluorescence Resonance Energy Transfer Intrinsically Disordered Proteins Protein Binding Protein Conformation Protein Folding Single Molecule Imaging Static Electricity |
