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| Computing cancer's weak spots 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Khamsi R.
  收藏 | 浏览/下载：48/0 | 提交时间：2020/07/28
ruxolitinib STAT3 protein antineoplastic agent transcription factor algorithm cancer computer simulation disease treatment drug development medicine Article cancer cell cancer radiotherapy enzyme inhibition gene activity gene expression regulation gene interaction gene mutation gene repression gene targeting human laboratory test malignant neoplasm molecular dynamics nonhuman oncologist priority journal RNA sequencing algorithm genetics mutation neoplasm personalized medicine procedures systems biology Algorithms Antineoplastic Agents Humans Mutation Neoplasms Precision Medicine Systems Biology Transcription Factors |
| Mechanisms generating cancer genome complexity from a single cell division error 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Umbreit N.T.; Zhang C.-Z.; Lynch L.D.; Blaine L.J.; Cheng A.M.; Tourdot R.; Sun L.; Almubarak H.F.; Judge K.; Mitchell T.J.; Spektor A.; Pellman D.
收藏 | 浏览/下载：15/0 | 提交时间：2020/07/28
myosin adenosine triphosphatase cancer chromosome detection method DNA error correction gene expression genome genomics mutation Article cell division cellular, subcellular and molecular biological phenomena and functions chromosome breakage chromosome breakage fusion bridge chromosome bridge formation chromosomes and chromosomal phenomena chromothripsis DNA damage DNA replication human interphase malignant neoplasm micronucleus mitosis oncogenomics priority journal single cell division error |
| Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者: He S.; Wu Z.; Tian Y.; Yu Z.; Yu J.; Wang X.; Li J.; Liu B.; Xu Y.
收藏 | 浏览/下载：38/0 | 提交时间：2020/07/28
actin related protein adenosine triphosphatase BRG1 BRM associated factor DNA multiprotein complex protein SWI retinoblastoma binding protein 2 SMARCC protein SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1 transcription factor transcription factor SNF unclassified drug cancer enzyme activity gene expression hydrolysis mutation protein alpha helix Article carboxy terminal sequence cell interaction cryoelectron microscopy disease association human malignant neoplasm molecular recognition mutation nucleosome priority journal protein function protein hydrolysis protein structure structure analysis Mammalia |
| The integrated stress response: From mechanism to disease 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者: [无可用作者姓名]
收藏 | 浏览/下载：30/0 | 提交时间：2020/07/28
initiation factor 2 cell component cognition disease homeostasis protein quality control 5' untranslated region adulthood Article cell reprogramming technique cellular stress response cognitive defect diabetes mellitus disease activity eukaryotic cell gene expression human long term memory malignant neoplasm metabolic disorder nerve degeneration nonhuman oxidative stress pathogenesis phosphorylation priority journal protein defect protein homeostasis RNA translation signal transduction translation initiation virus infection |
| An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者: Reinhard K.; Rengstl B.; Oehm P.; Michel K.; Billmeier A.; Hayduk N.; Klein O.; Kuna K.; Ouchan Y.; Wöll S.; Christ E.; Weber D.; Suchan M.; Bukur T.; Birtel M.; Jahndel V.; Mroz K.; Hobohm K.; Kranz L.; Diken M.; Kühlcke K.; Türeci Ö.; Sahin U.
收藏 | 浏览/下载：48/0 | 提交时间：2020/07/28
chimeric antigen receptor claudin 6 RNA vaccine antigen cell component protein RNA tumor vaccine animal cell animal experiment animal model animal tissue antigen presenting cell antineoplastic activity Article cell stimulation cell transport chimeric antigen receptor T-cell immunotherapy controlled study drug efficacy human human cell in vivo study mouse nonhuman phenotype priority journal real time polymerase chain reaction solid malignant neoplasm therapy effect vaccination coverage |
| Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者: Gilan O.; Rioja I.; Knezevic K.; Bell M.J.; Yeung M.M.; Harker N.R.; Lam E.Y.N.; Chung C.; Bamborough P.; Petretich M.; Urh M.; Atkinson S.J.; Bassil A.K.; Roberts E.J.; Vassiliadis D.; Burr M.L.; Preston A.G.S.; Wellaway C.; Werner T.; Gray J.R.; Michon A.-M.; Gobbetti T.; Kumar V.; Soden P.E.; Haynes A.; Vappiani J.; Tough D.F.; Taylor S.; Dawson S.-J.; Bantscheff M.; Lindon M.; Drewes G.; Demont E.H.; Daniels D.L.; Grandi P.; Prinjha R.K.; Dawson M.A.
收藏 | 浏览/下载：48/0 | 提交时间：2020/07/28
7 (3,5 dimethyl 4 isoxazolyl) 1,3 dihydro 8 methoxy 1 [1 (2 pyridinyl)ethyl] 2h imidazo[4,5 c]quinolin 2 one apremilast bromodomain and extraterminal domain protein 1 bromodomain and extraterminal domain protein 2 bromodomain inhibitor gsk 046 gsk 620 gsk 778 transcription factor unclassified drug cancer drug gene expression immune response inhibitor physiological response acute myeloid leukemia animal experiment animal model animal tissue antibody response antineoplastic activity antiproliferative activity apoptosis Article binding affinity controlled study crystal structure drug design drug efficacy drug protein binding drug selectivity drug specificity drug structure drug targeting gene expression high throughput screening human human cell IC50 immunomodulation in vivo study inflammation K-562 cell line malignant neoplasm MDA-MB-453 cell line MOLM-13 cell line mouse nonhuman priority journal psoriasis |
| Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者: Rougé L.; Chiang N.; Steffek M.; Kugel C.; Croll T.I.; Tam C.; Estevez A.; Arthur C.P.; Koth C.M.; Ciferri C.; Kraft E.; Payandeh J.; Nakamura G.; Koerber J.T.; Rohou A.
收藏 | 浏览/下载：26/0 | 提交时间：2020/07/28
CD20 antigen dimer epitope Fc receptor immunoglobulin F(ab) fragment obinutuzumab ocrelizumab ofatumumab rituximab tositumomab i 131 antibody antigen cell chemical binding composite gene expression genetic marker protein amino acid sequence antibody dependent cellular cytotoxicity antigen antibody complex antigen binding antigen structure Article cell death cell surface chemical bond complement dependent cytotoxicity drug protein binding drug targeting electron microscopy human humoral immune deficiency insect cell lipid raft malignant neoplasm molecular recognition multiple sclerosis nonhuman phagocytosis priority journal protein cross linking protein interaction stoichiometry surface plasmon resonance |
