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| Computing cancer's weak spots 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者: Khamsi R.
  收藏 | 浏览/下载：46/0 | 提交时间：2020/07/28
ruxolitinib STAT3 protein antineoplastic agent transcription factor algorithm cancer computer simulation disease treatment drug development medicine Article cancer cell cancer radiotherapy enzyme inhibition gene activity gene expression regulation gene interaction gene mutation gene repression gene targeting human laboratory test malignant neoplasm molecular dynamics nonhuman oncologist priority journal RNA sequencing algorithm genetics mutation neoplasm personalized medicine procedures systems biology Algorithms Antineoplastic Agents Humans Mutation Neoplasms Precision Medicine Systems Biology Transcription Factors |
| Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Weber C.; Zhou Y.; Lee J.G.; Looger L.L.; Qian G.; Ge C.; Capel B.
收藏 | 浏览/下载：35/0 | 提交时间：2020/07/28
STAT3 protein calcium histone demethylase STAT3 protein embryonic development gene expression sex determination temperature effect turtle animal cell animal experiment Article binding site calcium transport cell activation chromatin immunoprecipitation controlled study dimerization Dmrt1 gene embryo embryo development environmental temperature epigenetic repression female gene gene activation gene interaction gene targeting genetic transcription gonad high temperature immunofluorescence test Kdm6b gene male nonhuman priority journal protein phosphorylation real time polymerase chain reaction sex determination signal transduction temperature dependence thermoregulation transcription regulation upregulation Western blotting animal embryology gene expression regulation genetics metabolism phosphorylation sex determination process temperature turtle Reptilia Trachemys scripta Trachemys scripta elegans Animals Calcium Female Gene Expression Regulation, Developmental Jumonji Domain-Containing Histone Demethylases Male Phosphorylation Sex Determination Processes STAT3 Transcription Factor Temperature Transcription, Genetic Turtles |
| Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Walton R.T.; Christie K.A.; Whittaker M.N.; Kleinstiver B.P.
收藏 | 浏览/下载：27/0 | 提交时间：2020/07/28
adenine adenosine CRISPR associated endonuclease Cas9 cytosine guanosine SpG protein SpRY nuclease thymine unclassified drug Cas9 endonuclease Streptococcus pyogenes bacterium enzyme activity genetic engineering genetic variation genome Article CRISPR-CAS9 system DNA sequence enzyme activity gene editing gene targeting genetic variability human mutagenesis nonhuman priority journal protein engineering protein motif protein structure protospacer adjacent motif Streptococcus pyogenes chemistry CRISPR Cas system enzyme specificity gene editing gene targeting genetic predisposition genetics HEK293 cell line procedures protein domain Streptococcus pyogenes CRISPR-Associated Protein 9 CRISPR-Cas Systems Gene Editing Gene Targeting Genetic Predisposition to Disease HEK293 Cells Humans Mutagenesis Protein Domains Substrate Specificity |
| Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者: Uckelmann H.J.; Kim S.M.; Wong E.M.; Hatton C.; Giovinazzo H.; Gadrey J.Y.; Krivtsov A.V.; Rücker F.G.; Döhner K.; McGeehan G.M.; Levine R.L.; Bullinger L.; Vassiliou G.S.; Armstrong S.A.
收藏 | 浏览/下载：36/0 | 提交时间：2020/07/28
antileukemic agent methionine unclassified drug vtp 50469 biological development cancer cell disease treatment mutation numerical model oral health acute myeloid leukemia animal cell animal experiment animal model antineoplastic activity Article cell proliferation cell self-renewal chromatin controlled study drug targeting gene gene mutation leukemia cell molecularly targeted therapy mouse mouse model nonhuman NPM1 gene preleukemia priority journal Mus |
| Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者: Gilan O.; Rioja I.; Knezevic K.; Bell M.J.; Yeung M.M.; Harker N.R.; Lam E.Y.N.; Chung C.; Bamborough P.; Petretich M.; Urh M.; Atkinson S.J.; Bassil A.K.; Roberts E.J.; Vassiliadis D.; Burr M.L.; Preston A.G.S.; Wellaway C.; Werner T.; Gray J.R.; Michon A.-M.; Gobbetti T.; Kumar V.; Soden P.E.; Haynes A.; Vappiani J.; Tough D.F.; Taylor S.; Dawson S.-J.; Bantscheff M.; Lindon M.; Drewes G.; Demont E.H.; Daniels D.L.; Grandi P.; Prinjha R.K.; Dawson M.A.
收藏 | 浏览/下载：32/0 | 提交时间：2020/07/28
7 (3,5 dimethyl 4 isoxazolyl) 1,3 dihydro 8 methoxy 1 [1 (2 pyridinyl)ethyl] 2h imidazo[4,5 c]quinolin 2 one apremilast bromodomain and extraterminal domain protein 1 bromodomain and extraterminal domain protein 2 bromodomain inhibitor gsk 046 gsk 620 gsk 778 transcription factor unclassified drug cancer drug gene expression immune response inhibitor physiological response acute myeloid leukemia animal experiment animal model animal tissue antibody response antineoplastic activity antiproliferative activity apoptosis Article binding affinity controlled study crystal structure drug design drug efficacy drug protein binding drug selectivity drug specificity drug structure drug targeting gene expression high throughput screening human human cell IC50 immunomodulation in vivo study inflammation K-562 cell line malignant neoplasm MDA-MB-453 cell line MOLM-13 cell line mouse nonhuman priority journal psoriasis |
| Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者: Rougé L.; Chiang N.; Steffek M.; Kugel C.; Croll T.I.; Tam C.; Estevez A.; Arthur C.P.; Koth C.M.; Ciferri C.; Kraft E.; Payandeh J.; Nakamura G.; Koerber J.T.; Rohou A.
收藏 | 浏览/下载：26/0 | 提交时间：2020/07/28
CD20 antigen dimer epitope Fc receptor immunoglobulin F(ab) fragment obinutuzumab ocrelizumab ofatumumab rituximab tositumomab i 131 antibody antigen cell chemical binding composite gene expression genetic marker protein amino acid sequence antibody dependent cellular cytotoxicity antigen antibody complex antigen binding antigen structure Article cell death cell surface chemical bond complement dependent cytotoxicity drug protein binding drug targeting electron microscopy human humoral immune deficiency insect cell lipid raft malignant neoplasm molecular recognition multiple sclerosis nonhuman phagocytosis priority journal protein cross linking protein interaction stoichiometry surface plasmon resonance |
| Next-generation epigenetic inhibitors 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者: Filippakopoulos P.; Knapp S.
收藏 | 浏览/下载：21/0 | 提交时间：2020/07/28
biological marker bromodomain inhibitor DNA experiment genetic analysis inhibitor Article binding site down regulation gene expression histone modification human nonhuman pleiotropy priority journal protein domain protein folding protein interaction protein processing protein targeting transcription elongation transcription regulation |
