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Structural basis of Gs and Gi recognition by the human glucagon receptor 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Qiao A.;  Han S.;  Li X.;  Li Z.;  Zhao P.;  Dai A.;  Chang R.;  Tai L.;  Tan Q.;  Chu X.;  Ma L.;  Thorsen T.S.;  Reedtz-Runge S.;  Yang D.;  Wang M.-W.;  Sexton P.M.;  Wootten D.;  Sun F.;  Zhao Q.;  Wu B.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
cyclic AMP  glucagon  glucagon receptor  inhibitory guanine nucleotide binding protein  stimulatory guanine nucleotide binding protein  glucagon receptor  inhibitory guanine nucleotide binding protein  protein binding  stimulatory guanine nucleotide binding protein  chemical binding  enzyme activity  gene expression  mutagenicity  protein  alpha helix  Article  binding affinity  carboxy terminal sequence  conformational transition  cryoelectron microscopy  human  molecular recognition  mutagenesis  priority journal  protein binding  protein function  protein protein interaction  protein structure  signal transduction  binding site  chemistry  metabolism  molecular model  protein conformation  ultrastructure  Binding Sites  Cryoelectron Microscopy  Glucagon  GTP-Binding Protein alpha Subunits, Gi-Go  GTP-Binding Protein alpha Subunits, Gs  Humans  Models, Molecular  Protein Binding  Protein Conformation  Protein Conformation, alpha-Helical  Receptors, Glucagon  Signal Transduction  
Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Wingler L.M.;  Skiba M.A.;  McMahon C.;  Staus D.P.;  Kleinhenz A.L.W.;  Suomivuori C.-M.;  Latorraca N.R.;  Dror R.O.;  Lefkowitz R.J.;  Kruse A.C.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
angiotensin 1 receptor  beta arrestin  G protein coupled receptor  biochemistry  crystal chemistry  crystal structure  physiological response  protein  signaling  allosterism  alpha helix  amino terminal sequence  Article  binding affinity  binding site  carboxy terminal sequence  conformational transition  crystallization  hydrogen bond  molecular dynamics  priority journal  protein binding  protein conformation  protein protein interaction  protein stability  signal transduction  thermostability  
Structural insights into immunoglobulin M 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:  Li Y.;  Wang G.;  Li N.;  Wang Y.;  Zhu Q.;  Chu H.;  Wu W.;  Tan Y.;  Yu F.;  Su X.-D.;  Gao N.;  Xiao J.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
immunoglobulin M  secretory component  antibody  immunity  molecular analysis  polymer  protein  Article  binding site  conformational transition  cryoelectron microscopy  crystal structure  human  hydrophobicity  nonhuman  oligomerization  priority journal  protein assembly  protein domain  protein function  protein interaction  protein stability  protein structure  protein transport  surface area  
Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Suomivuori C.-M.;  Latorraca N.R.;  Wingler L.M.;  Eismann S.;  King M.C.;  Kleinhenz A.L.W.;  Skiba M.A.;  Staus D.P.;  Kruse A.C.;  Lefkowitz R.J.;  Dror R.O.
收藏  |  浏览/下载：25/0  |  提交时间：2020/07/28
angiotensin 1 receptor  beta arrestin 1  beta arrestin 2  G protein coupled receptor  rhodopsin  chemical binding  design method  ligand  molecular analysis  protein  signaling  allosterism  Article  carboxy terminal sequence  conformational transition  controlled study  crystal structure  human  ligand binding  molecular dynamics  priority journal  protein conformation  signal transduction  structural model  
Democratizing cryo-EM: Broadening access to an expanding field 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Tachibana C.
收藏  |  浏览/下载：190/0  |  提交时间：2020/07/28
membrane protein  nucleic acid  democratization  detection method  electron microscopy  algorithm  Article  conformational transition  cryoelectron microscopy  crystallization  electron diffraction  electron tomography  freezing  glycosylation  human  microcrystal electron diffraction  nanoimaging  nuclear magnetic resonance spectroscopy  priority journal  protein processing  protein structure  protein synthesis  social welfare  transmission electron microscopy  X ray crystallography  
Structure of an active human histone pre-mRNA 3′-end processing machinery 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Sun Y.;  Zhang Y.;  Aik W.S.;  Yang X.-C.;  Marzluff W.F.;  Walz T.;  Dominski Z.;  Tong L.
收藏  |  浏览/下载：218/0  |  提交时间：2020/07/28
beta lactamase  cleavage and polyadenylation specificity factor  cleavage and polyadenylation specificity factor 100  cleavage and polyadenylation specificity factor 73  endonuclease  histone  membrane protein  messenger RNA precursor  recombinant protein  small nuclear ribonucleoprotein  small nuclear RNA  symplekin  U7 small nuclear ribonucleoprotein  unclassified drug  enzyme activity  genetic analysis  metazoan  protein  recombination  RNA  3' untranslated region  amino terminal sequence  Article  biochemical analysis  carboxy terminal sequence  conformational transition  controlled study  cryoelectron microscopy  enzyme active site  gene rearrangement  genetic analysis  hydrogen bond  molecular recognition  mutagenesis  polyadenylation  priority journal  protein conformation  protein protein interaction  RNA cleavage  RNA processing  RNA sequencing  Amphora  Metazoa