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Plastome structure, phylogenomics and evolution of plastid genes in Swertia (Gentianaceae) in the Qing-Tibetan Plateau 期刊论文
BMC PLANT BIOLOGY, 2022, 卷号: 22, 期号: 1
作者:  Cao, Qian;  Gao, Qingbo;  Ma, Xiaolei;  Zhang, Faqi;  Xing, Rui;  Chi, Xiaofeng;  Chen, Shilong
收藏  |  浏览/下载：35/0  |  提交时间：2022/04/28
COMPLETE CHLOROPLAST GENOME  COMPLETE NUCLEOTIDE-SEQUENCE  PHYLOGENETIC ANALYSIS  MOLECULAR PHYLOGENY  EFFECTIVE NUMBER  ALPINE PLANTS  CODON USAGE  DNA  SUBSTITUTION  GENTIANEAE  
Short and long reads chloroplast genome assemblies and phylogenomics of Artemisia tangutica (Asteraceae) 期刊论文
BIOLOGIA, 2022, 卷号: 77, 期号: 4
作者:  Yu, Jingya;  Xia, Mingze;  Wang, Yongcui;  Chi, Xiaofeng;  Xu, Hao;  Chen, Shilong;  Zhang, Faqi
收藏  |  浏览/下载：43/0  |  提交时间：2022/04/28
ACETYL-COA CARBOXYLASE  PHYLOGENETIC ANALYSIS  EVOLUTIONARY ANALYSIS  CHEMICAL-COMPOSITION  MOLECULAR PHYLOGENY  GENE ORGANIZATION  ACCD GENE  SEQUENCE  DNA  MITOCHONDRIAL  
Molecular Karyotyping on Populus simonii x P. nigra and the Derived Doubled Haploid 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 卷号: 22, 期号: 21
作者:  Liu, Bo;  Wang, Sui;  Tao, Xiaoyan;  Liu, Caixia;  Qu, Guanzheng;  Dou, Quanwen
收藏  |  浏览/下载：26/0  |  提交时间：2022/04/28
IN-SITU HYBRIDIZATION  RIBOSOMAL DNA  PLANT GENOME  FISH  CHROMOSOMES  SEQUENCE  LOCI  GISH  
A review of Denisovans 期刊论文
CHINESE SCIENCE BULLETIN-CHINESE, 2020, 卷号: 65, 期号: 25
作者:  Xia, Huan;  Zhang, Dongju;  Chen, Fahu
收藏  |  浏览/下载：34/0  |  提交时间：2022/06/21
LATE MIDDLE PLEISTOCENE  ALTITUDE ADAPTATION  MITOCHONDRIAL-DNA  GENETIC HISTORY  GENOME SEQUENCE  HOMININ TEETH  MODERN HUMANS  HUMAN REMAINS  SOUTH CHINA  NEANDERTHAL  
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Walton R.T.;  Christie K.A.;  Whittaker M.N.;  Kleinstiver B.P.
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/28
adenine  adenosine  CRISPR associated endonuclease Cas9  cytosine  guanosine  SpG protein  SpRY nuclease  thymine  unclassified drug  Cas9 endonuclease Streptococcus pyogenes  bacterium  enzyme activity  genetic engineering  genetic variation  genome  Article  CRISPR-CAS9 system  DNA sequence  enzyme activity  gene editing  gene targeting  genetic variability  human  mutagenesis  nonhuman  priority journal  protein engineering  protein motif  protein structure  protospacer adjacent motif  Streptococcus pyogenes  chemistry  CRISPR Cas system  enzyme specificity  gene editing  gene targeting  genetic predisposition  genetics  HEK293 cell line  procedures  protein domain  Streptococcus pyogenes  CRISPR-Associated Protein 9  CRISPR-Cas Systems  Gene Editing  Gene Targeting  Genetic Predisposition to Disease  HEK293 Cells  Humans  Mutagenesis  Protein Domains  Substrate Specificity  
Translating preclinical models to humans 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Brubaker D.K.;  Lauffenburger D.A.
收藏  |  浏览/下载：40/0  |  提交时间：2020/07/28
detection method  model  Article  bioengineering  biomedicine  cell differentiation  cell proliferation  computer model  conceptual framework  DNA sequence  drug development  epithelium cell  gene expression profiling  high throughput sequencing  human  machine learning  molecular dynamics  nonhuman  phenotype  priority journal  proteomics  RNA sequence  sex difference  signal transduction  T lymphocyte  transcription regulation  transcriptomics  translational research  
Structure of nucleosome-bound human BAF complex 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  He S.;  Wu Z.;  Tian Y.;  Yu Z.;  Yu J.;  Wang X.;  Li J.;  Liu B.;  Xu Y.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/28
actin related protein  adenosine triphosphatase  BRG1 BRM associated factor  DNA  multiprotein complex  protein SWI  retinoblastoma binding protein 2  SMARCC protein  SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily B member 1  transcription factor  transcription factor SNF  unclassified drug  cancer  enzyme activity  gene expression  hydrolysis  mutation  protein  alpha helix  Article  carboxy terminal sequence  cell interaction  cryoelectron microscopy  disease association  human  malignant neoplasm  molecular recognition  mutation  nucleosome  priority journal  protein function  protein hydrolysis  protein structure  structure analysis  Mammalia  
Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者:  Britton C.S.;  Sorrells T.R.;  Johnson A.D.
收藏  |  浏览/下载：19/0  |  提交时间：2020/07/28
DNA binding protein  fungal protein  homeodomain protein  Matalpha2 protein  regulator protein  transcription factor  unclassified drug  gene  gene expression  protein  amino acid sequence  Article  cladistics  controlled study  gene deletion  gene expression regulation  gene repression  gene sequence  gene structure  molecular evolution  nonhuman  priority journal  protein DNA binding  protein function  protein structure  Saccharomycotina  sequence homology  species  transcription regulation  Wickerhamomyces anomalus  Fungi  
Structural basis for strand-transfer inhibitor binding to HIV intasomes 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Passos D.O.;  Li M.;  Jóźwik I.K.;  Zhao X.Z.;  Santos-Martins D.;  Yang R.;  Smith S.J.;  Jeon Y.;  Forli S.;  Hughes S.H.;  Burke T.R.;  Jr.;  Craigie R.;  Lyumkis D.
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/28
bictegravir  nucleoprotein  protein intasome  unclassified drug  viral protein  bictegravir  fused heterocyclic rings  integrase  integrase inhibitor  multiprotein complex  naphthyridine derivative  nucleoprotein  biochemistry  chemical binding  human immunodeficiency virus  inhibitor  protein  ultrastructure  amino terminal sequence  Article  carboxy terminal sequence  catalysis  cryoelectron microscopy  drug design  drug efficacy  drug protein binding  drug resistance  drug structure  enzyme active site  human  Human immunodeficiency virus infection  nonhuman  priority journal  protein purification  protein structure  antiviral resistance  chemistry  drug effect  genetics  Human immunodeficiency virus  virus DNA cell DNA interaction  Cryoelectron Microscopy  Drug Design  Drug Resistance, Viral  Heterocyclic Compounds, 4 or More Rings  HIV  HIV Integrase  HIV Integrase Inhibitors  Humans  Multiprotein Complexes  Naphthyridines  Nucleoproteins  Virus Integration  
Structural basis of second-generation HIV integrase inhibitor action and viral resistance 期刊论文
, 2020, 卷号: 367, 期号: 6479
作者:  Cook N.J.;  Li W.;  Berta D.;  Badaoui M.;  Ballandras-Colas A.;  Nans A.;  Kotecha A.;  Rosta E.;  Engelman A.N.;  Cherepanov P.
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/28
bictegravir  dolutegravir  lens epithelium derived growth factor  magnesium ion  bictegravir  dolutegravir  fused heterocyclic rings  glutamine  glycine  histidine  integrase  integrase inhibitor  magnesium  serine  acquired immune deficiency syndrome  amino acid  drug  human immunodeficiency virus  inhibitor  protein  ultrastructure  virus  amino acid substitution  amino terminal sequence  Article  carboxy terminal sequence  cryoelectron microscopy  DNA binding  drug design  drug protein binding  drug structure  enzyme active site  gene mutation  Human immunodeficiency virus 1  in vitro study  molecular dynamics  molecular stability  nonhuman  pharmacophore  polarization  priority journal  protonation  virus resistance  antiviral resistance  chemistry  genetics  human  mutation  procedures  single molecule imaging  Amino Acid Substitution  Catalytic Domain  Cryoelectron Microscopy  Drug Resistance, Viral  Glutamine  Glycine  Heterocyclic Compounds, 3-Ring  Heterocyclic Compounds, 4 or More Rings  Histidine  HIV Integrase  HIV Integrase Inhibitors  Humans  Magnesium  Mutation  Serine  Single Molecule Imaging