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| Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Walton R.T.; Christie K.A.; Whittaker M.N.; Kleinstiver B.P.
  收藏 | 浏览/下载：20/0 | 提交时间：2020/07/28
adenine adenosine CRISPR associated endonuclease Cas9 cytosine guanosine SpG protein SpRY nuclease thymine unclassified drug Cas9 endonuclease Streptococcus pyogenes bacterium enzyme activity genetic engineering genetic variation genome Article CRISPR-CAS9 system DNA sequence enzyme activity gene editing gene targeting genetic variability human mutagenesis nonhuman priority journal protein engineering protein motif protein structure protospacer adjacent motif Streptococcus pyogenes chemistry CRISPR Cas system enzyme specificity gene editing gene targeting genetic predisposition genetics HEK293 cell line procedures protein domain Streptococcus pyogenes CRISPR-Associated Protein 9 CRISPR-Cas Systems Gene Editing Gene Targeting Genetic Predisposition to Disease HEK293 Cells Humans Mutagenesis Protein Domains Substrate Specificity |
| Liquid-liquid phase separation drives skin barrier formation 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者: Quiroz F.G.; Fiore V.F.; Levorse J.; Polak L.; Wong E.; Pasolli H.A.; Fuchs E.
收藏 | 浏览/下载：27/0 | 提交时间：2020/07/28
filaggrin keratohyalin coalescence differentiation separation skin skin disorder stratification amino acid composition Article bioengineering biophysics cell differentiation cell function cell structure epidermis cell genetic transfection human keratinocyte liquid live cell imaging molecular dynamics nonhuman pH phase separation phase transition priority journal proteomics sequence analysis signal transduction skin skin surface Mus |
| The genetic architecture of the human cerebral cortex 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者: Grasby K.L.; Jahanshad N.; Painter J.N.; Colodro-Conde L.; Bralten J.; Hibar D.P.; Lind P.A.; Pizzagalli F.; Ching C.R.K.; McMahon M.A.B.; Shatokhina N.; Zsembik L.C.P.; Thomopoulos S.I.; Zhu A.H.; Strike L.T.; Agartz I.; Alhusaini S.; Almeida M.A.A.; Alnæs D.; Amlien I.K.; Andersson M.; Ard T.; Armstrong N.J.; Ashley-Koch A.; Atkins J.R.; Bernard M.; Brouwer R.M.; Buimer E.E.L.; Bülow R.; Bürger C.; Cannon D.M.; Chakravarty M.; Chen Q.; Cheung J.W.; Couvy-Duchesne B.; Dale A.M.; Dalvie S.; de Araujo T.K.; de Zubicaray G.I.; de Zwarte S.M.C.; den Braber A.; Doan N.T.; Dohm K.; Ehrlich S.; Engelbrecht H.-R.; Erk S.; Fan C.C.; Fedko I.O.; Foley S.F.; Ford J.M.; Fukunaga M.; Garrett M.E.; Ge T.; Giddaluru S.; Goldman A.L.; Green M.J.; Groenewold N.A.; Grotegerd D.; Gurholt T.P.; Gutman B.A.; Hansell N.K.; Harris M.A.; Harrison M.B.; Haswell C.C.; Hauser M.; Herms S.; Heslenfeld D.J.; Ho N.F.; Hoehn D.; Hoffmann P.; Holleran L.; Hoogman M.; Hottenga J.-J.; Ikeda M.; Janowitz D.; Jansen I.E.; Jia T.; Jockwitz C.; Kanai R.; Karama S.; Kasperaviciute D.; Kaufmann T.; Kelly S.; Kikuchi M.; Klein M.; Knapp M.; Knodt A.R.; Krämer B.; Lam M.; Lancaster T.M.; Lee P.H.; Lett T.A.; Lewis L.B.; Lopes-Cendes I.; Luciano M.; Macciardi F.; Marquand A.F.; Mathias S.R.; Melzer T.R.; Milaneschi Y.; Mirza-Schreiber N.; Moreira J.C.V.; Mühleisen T.W.; Müller-Myhsok B.; Najt P.; Nakahara S.; Nho K.; Olde Loohuis L.M.; Orfanos D.P.; Pearson J.F.; Pitcher T.L.; Pütz B.; Quidé Y.; Ragothaman A.; Rashid F.M.; Reay W.R.; Redlich R.; Reinbold C.S.; Repple J.; Richard G.; Riedel B.C.; Risacher S.L.; Rocha C.S.; Mota N.R.; Salminen L.; Saremi A.; Saykin A.J.; Schlag F.; Schmaal L.; Schofield P.R.; Secolin R.; Shapland C.Y.; Shen L.; Shin J.; Shumskaya E.; Sønderby I.E.; Sprooten E.; Tansey K.E.; Teumer A.; Thalamuthu A.; Tordesillas-Gutiérrez D.; Turner J.A.; Uhlmann A.; Vallerga C.L.; van der Meer D.; van Donkelaar M.M.J.; van Eijk L.; van Erp T.G.M.; van Haren N.E.M.; van Rooij D.; van Tol M.-J.; Veldink J.H.; Verhoef E.; Walton E.; Wang M.; Wang Y.; Wardlaw J.M.; Wen W.; Westlye L.T.; Whelan C.D.; Witt S.H.; Wittfeld K.; Wolf C.; Wolfers T.; Wu J.Q.; Yasuda C.L.; Zaremba D.; Zhang Z.; Zwiers M.P.; Artiges E.; Assareh A.A.; Ayesa-Arriola R.; Belger A.; Brandt C.L.; Brown G.G.; Cichon S.; Curran J.E.; Davies G.E.; Degenhardt F.; Dennis M.F.; Dietsche B.; Djurovic S.; Doherty C.P.; Espiritu R.; Garijo D.; Gil Y.; Gowland P.A.; Green R.C.; Häusler A.N.; Heindel W.; Ho B.-C.; Hoffmann W.U.; Holsboer F.; Homuth G.; Hosten N.; Jack C.R.; Jang M.; Jansen A.; Kimbrel N.A.; Kolskår K.; Koops S.; Krug A.; Lim K.O.; Luykx J.J.; Mathalon D.H.; Mather K.A.; Mattay V.S.; Matthews S.; van Son J.M.; McEwen S.C.; Melle I.; Morris D.W.; Mueller B.A.; Nauck M.; Nordvik J.E.; Nöthen M.M.; O'Leary D.S.; Opel N.; Martinot M.-L.P.; Bruce Pike G.; Preda A.; Quinlan E.B.; Rasser P.E.; Ratnakar V.; Reppermund S.; Steen V.M.; Tooney P.A.; Torres F.R.; Veltman D.J.; Voyvodic J.T.; Whelan R.; White T.; Yamamori H.; Adams H.H.H.; Bis J.C.; Debette S.; Decarli C.; Fornage M.; Gudnason V.; Hofer E.; Arfan Ikram M.; Launer L.; Longstreth W.T.; Lopez O.L.; Mazoyer B.; Mosley T.H.; Roshchupkin G.V.; Satizabal C.L.; Schmidt R.; Seshadri S.; Yang Q.; Alvim M.K.M.; Ames D.; Anderson T.J.; Andreassen O.A.; Arias-Vasquez A.; Bastin M.E.; Baune B.T.; Beckham J.C.; Blangero J.; Boomsma D.I.; Brodaty H.; Brunner H.G.; Buckner R.L.; Buitelaar J.K.; Bustillo J.R.; Cahn W.; Cairns M.J.; Calhoun V.; Carr V.J.; Caseras X.; Caspers S.; Cavalleri G.L.; Cendes F.; Corvin A.; Crespo-Facorro B.; Dalrymple-Alford J.C.; Dannlowski U.; de Geus E.J.C.; Deary I.J.; Delanty N.; Depondt C.; Desrivières S.; Donohoe G.; Espeseth T.; Fernández G.; Fisher S.E.; Flor H.; Forstner A.J.; Francks C.; Franke B.; Glahn D.C.; Gollub R.L.; Grabe H.J.; Gruber O.; Håberg A.K.; Hariri A.R.; Hartman C.A.; Hashimoto R.; Heinz A.; Henskens F.A.; Hillegers M.H.J.; Hoekstra P.J.; Holmes A.J.; Elliot Hong L.; Hopkins W.D.; Hulshoff Pol H.E.; Jernigan T.L.; Jönsson E.G.; Kahn R.S.; Kennedy M.A.; Kircher T.T.J.; Kochunov P.; Kwok J.B.J.; Le Hellard S.; Loughland C.M.; Martin N.G.; Martinot J.-L.; McDonald C.; McMahon K.L.; Meyer-Lindenberg A.; Michie P.T.; Morey R.A.; Mowry B.; Nyberg L.; Oosterlaan J.; Ophoff R.A.; Pantelis C.; Paus T.; Pausova Z.; Penninx B.W.J.H.; Polderman T.J.C.; Posthuma D.; Rietschel M.; Roffman J.L.; Rowland L.M.; Sachdev P.S.; Sämann P.G.; Schall U.; Schumann G.; Scott R.J.; Sim K.; Sisodiya S.M.; Smoller J.W.; Sommer I.E.; Pourcain B.S.; Stein D.J.; Toga A.W.; Trollor J.N.; van der Wee N.J.A.; van't Ent D.; Völzke H.; Walter H.; Weber B.; Weinberger D.R.; Wright M.J.; Zhou J.; Stein J.L.; Thompson P.M.; Medland S.E.; Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group
收藏 | 浏览/下载：48/0 | 提交时间：2020/07/28
brain genetic analysis meta-analysis resonance signaling surface area Article bioinformatics brain cortex brain function brain region brain tissue cortical thickness (brain) educational status evidence based medicine gene control gene locus genetic association genetic correlation genetic variability genome-wide association study human human genetics priority journal surface area tissue structure Wnt signaling anatomy and histology attention deficit disorder brain cortex brain mapping cognition genetic variation genetics meta analysis nuclear magnetic resonance imaging organ size Parkinson disease Attention Deficit Disorder with Hyperactivity Brain Mapping Cerebral Cortex Cognition Genetic Loci Genetic Variation Genome-Wide Association Study Humans Magnetic Resonance Imaging Organ Size Parkinson Disease |
| TTC5 mediates autoregulation of tubulin via mRNA degradation 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者: Lin Z.; Gasic I.; Chandrasekaran V.; Peters N.; Shao S.; Mitchison T.J.; Hegde R.S.
收藏 | 浏览/下载：22/0 | 提交时间：2020/07/28
messenger RNA mutant protein polypeptide recombinant protein regulator protein tetratricopeptide protein 5 tubulin unclassified drug biodegradation chromosome peptide protein RNA amino terminal sequence animal cell Article autoregulation binding site chromosome segregation controlled study cryoelectron microscopy genetic code human human cell Leporidae mitosis molecular model nonhuman priority journal protein analysis protein binding protein interaction protein structure reticulocyte ribosome RNA degradation RNA translation tubulin gene |
| De novo design of protein logic gates 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者: Chen Z.; Kibler R.D.; Hunt A.; Busch F.; Pearl J.; Jia M.; VanAernum Z.L.; Wicky B.I.M.; Dods G.; Liao H.; Wilken M.S.; Ciarlo C.; Green S.; El-Samad H.; Stamatoyannopoulos J.; Wysocki V.H.; Jewett M.C.; Boyken S.E.; Baker D.
收藏 | 浏览/下载：25/0 | 提交时间：2020/07/28
cell design method gene expression genetic analysis protein activation domain Article binding affinity circular dichroism controlled study de novo design design DNA binding motif enzyme activity genetic transcription human human cell hydrogen bond hydrophobicity mass spectrometry native mass spectrometry nonhuman priority journal protein protein interaction protein structure RNA translation stoichiometry thermodynamics two hybrid system X ray crystallography chemistry genetics logic metabolism protein analysis protein engineering protein processing synthetic biology T lymphocyte yeast HAVCR2 protein, human hepatitis A virus cellular receptor 2 Hepatitis A Virus Cellular Receptor 2 Humans Logic Mass Spectrometry Protein Engineering Protein Interaction Maps Protein Processing, Post-Translational Synthetic Biology T-Lymphocytes Transcription, Genetic Yeasts |
| Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者: Rougé L.; Chiang N.; Steffek M.; Kugel C.; Croll T.I.; Tam C.; Estevez A.; Arthur C.P.; Koth C.M.; Ciferri C.; Kraft E.; Payandeh J.; Nakamura G.; Koerber J.T.; Rohou A.
收藏 | 浏览/下载：19/0 | 提交时间：2020/07/28
CD20 antigen dimer epitope Fc receptor immunoglobulin F(ab) fragment obinutuzumab ocrelizumab ofatumumab rituximab tositumomab i 131 antibody antigen cell chemical binding composite gene expression genetic marker protein amino acid sequence antibody dependent cellular cytotoxicity antigen antibody complex antigen binding antigen structure Article cell death cell surface chemical bond complement dependent cytotoxicity drug protein binding drug targeting electron microscopy human humoral immune deficiency insect cell lipid raft malignant neoplasm molecular recognition multiple sclerosis nonhuman phagocytosis priority journal protein cross linking protein interaction stoichiometry surface plasmon resonance |
