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De novo protein design enables the precise induction of RSV-neutralizing antibodies 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Sesterhenn F.;  Yang C.;  Bonet J.;  Cramer J.T.;  Wen X.;  Wang Y.;  Chiang C.-I.;  Abriata L.A.;  Kucharska I.;  Castoro G.;  Vollers S.S.;  Galloux M.;  Dheilly E.;  Rosset S.;  Corthésy P.;  Georgeon S.;  Villard M.;  Richard C.-A.;  Descamps D.;  Delgado T.;  Oricchio E.;  Rameix-Welti M.-A.;  Más V.;  Ervin S.;  Eléouët J.-F.;  Riffault S.;  Bates J.T.;  Julien J.-P.;  Li Y.;  Jardetzky T.;  Krey T.;  Correia B.E.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/28
algorithm  antibody  design  neutralization  protein  vaccine  Mus  Primates  Respiratory syncytial virus  Rice stripe virus  epitope  fusion protein  nanobody  neutralizing antibody  respiratory syncytial virus vaccine  biology  biosynthesis  chemistry  human  Human respiratory syncytial virus  immunology  procedures  protein conformation  protein engineering  protein motif  Amino Acid Motifs  Antibodies, Neutralizing  Computational Biology  Humans  Immunodominant Epitopes  Protein Conformation  Protein Engineering  Recombinant Fusion Proteins  Respiratory Syncytial Virus Vaccines  Respiratory Syncytial Virus, Human  Single-Domain Antibodies  
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Yuan M.;  Wu N.C.;  Zhu X.;  Lee C.-C.D.;  So R.T.Y.;  Lv H.;  Mok C.K.P.;  Wilson I.A.
收藏  |  浏览/下载：17/0  |  提交时间：2020/07/28
angiotensin converting enzyme 2  epitope  neutralizing antibody  virus hemagglutinin  virus spike protein  angiotensin converting enzyme 2  coronavirus receptors  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  neutralizing antibody  spike glycoprotein, SARS-CoV  spike protein, SARS-CoV-2  virus antibody  virus antigen  virus receptor  antibody  antigen  chemical binding  crystal structure  protein  respiratory disease  viral disease  virus  amino terminal sequence  antibody isolation  antigen binding  antigenicity  Article  binding affinity  binding site  conservation biology  controlled study  coronavirus disease 2019  cross reaction  cryoelectron microscopy  crystal structure  enzyme linked immunosorbent assay  epidemic  glycosylation  human  hydrophobicity  immune response  in vitro study  in vivo study  light chain  nonhuman  priority journal  protein conformation  protein domain  protein interaction  protein localization  protein structure  protein targeting  receptor binding  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  amino acid sequence  antibody affinity  Betacoronavirus  binding site  chemistry  immunology  metabolism  molecular model  SARS coronavirus  X ray crystallography  Coronavirus  SARS coronavirus  Amino Acid Sequence  Antibodies, Neutralizing  Antibodies, Viral  Antibody Affinity  Antigens, Viral  Betacoronavirus  Binding Sites  Cross Reactions  Crystallography, X-Ray  Epitopes  Models, Molecular  Peptidyl-Dipeptidase A  Protein Conformation  Protein Domains  Protein Interaction Domains and Motifs  Receptors, Virus  SARS Virus  Spike Glycoprotein, Coronavirus  
Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Wu N.C.;  Thompson A.J.;  Lee J.M.;  Su W.;  Arlian B.M.;  Xie J.;  Lerner R.A.;  Yen H.-L.;  Bloom J.D.;  Wilson I.A.
收藏  |  浏览/下载：19/0  |  提交时间：2020/07/28
genetic analysis  hematology  influenza  mutation  pathogenicity  vaccine  virus  epitope  influenza vaccine  Influenza virus hemagglutinin  neutralizing antibody  virus antibody  chemistry  genetics  human  immunological tolerance  immunology  Influenza A virus (H1N1)  Influenza A virus (H3N2)  mutation  Antibodies, Neutralizing  Antibodies, Viral  Hemagglutinin Glycoproteins, Influenza Virus  Humans  Immune Tolerance  Immunodominant Epitopes  Influenza A Virus, H1N1 Subtype  Influenza A Virus, H3N2 Subtype  Influenza Vaccines  Mutation  
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Wu Y.;  Wang F.;  Shen C.;  Peng W.;  Li D.;  Zhao C.;  Li Z.;  Li S.;  Bi Y.;  Yang Y.;  Gong Y.;  Xiao H.;  Fan Z.;  Tan S.;  Wu G.;  Tan W.;  Lu X.;  Fan C.;  Wang Q.;  Liu Y.;  Zhang C.;  Qi J.;  Gao G.F.;  Gao F.;  Liu L.
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/28
Coronavirus  angiotensin converting enzyme 2  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  monoclonal antibody  neutralizing antibody  virus antibody  virus receptor  animal  chemistry  Coronavirus infection  disease model  human  immunology  isolation and purification  lung  mouse  pandemic  protein domain  serodiagnosis  virology  virus load  virus pneumonia  Animals  Antibodies, Monoclonal  Antibodies, Neutralizing  Antibodies, Viral  Coronavirus Infections  Disease Models, Animal  Humans  Immunodominant Epitopes  Lung  Mice  Neutralization Tests  Pandemics  Peptidyl-Dipeptidase A  Pneumonia, Viral  Protein Domains  Receptors, Virus  Spike Glycoprotein, Coronavirus  Viral Load  
Development of an inactivated vaccine candidate for SARS-CoV-2 期刊论文
, 2020, 卷号: 369, 期号: 6499
作者:  Gao Q.;  Bao L.;  Mao H.;  Wang L.;  Xu K.;  Yang M.;  Li Y.;  Zhu L.;  Wang N.;  Lv Z.;  Gao H.;  Ge X.;  Kan B.;  Hu Y.;  Liu J.;  Cai F.;  Jiang D.;  Yin Y.;  Qin C.;  Li J.;  Gong X.;  Lou X.;  Shi W.;  Wu D.;  Zhang H.;  Zhu L.;  Deng W.;  Li Y.;  Lu J.;  Li C.;  Wang X.;  Yin W.;  Zhang Y.;  Qin C.
收藏  |  浏览/下载：33/0  |  提交时间：2020/07/28
COVID-19 vaccine  immunoglobulin G  inactivated vaccine  neutralizing antibody  virus antibody  virus vaccine  animal  Bagg albino mouse  Betacoronavirus  biosynthesis  blood  Chlorocebus aethiops  Coronavirus infection  dose response  female  immunology  isolation and purification  male  mouse  pandemic  pilot study  rat  rhesus monkey  vaccine immunogenicity  Vero cell line  virology  virus load  virus pneumonia  Wistar rat  Animals  Antibodies, Neutralizing  Antibodies, Viral  Betacoronavirus  Chlorocebus aethiops  Coronavirus Infections  Dose-Response Relationship, Immunologic  Female  Immunogenicity, Vaccine  Immunoglobulin G  Macaca mulatta  Male  Mice  Mice, Inbred BALB C  Pandemics  Pilot Projects  Pneumonia, Viral  Rats  Rats, Wistar  Vaccines, Inactivated  Vero Cells  Viral Load  Viral Vaccines