气候变化领域集成服务门户(CCPortal): Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses

CCPortal

DOI	10.1126/science.aaz5143
	Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses
	Wu N.C.; Thompson A.J.; Lee J.M.; Su W.; Arlian B.M.; Xie J.; Lerner R.A.; Yen H.-L.; Bloom J.D.; Wilson I.A.
发表日期	2020
ISSN	0036-8075
起始页码	1335
结束页码	1340
卷号	368 期号:6497
英文摘要	The discovery and characterization of broadly neutralizing human antibodies (bnAbs) to the highly conserved stem region of influenza hemagglutinin (HA) have contributed to considerations of a universal influenza vaccine. However, the potential for resistance to stem bnAbs also needs to be more thoroughly evaluated. Using deep mutational scanning, with a focus on epitope residues, we found that the genetic barrier to resistance to stem bnAbs is low for the H3 subtype but substantially higher for the H1 subtype owing to structural differences in the HA stem. Several strong resistance mutations in H3 can be observed in naturally circulating strains and do not reduce in vitro viral fitness and in vivo pathogenicity. This study highlights a potential challenge for development of a truly universal influenza vaccine. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	genetic analysis hematology influenza mutation pathogenicity vaccine virus epitope influenza vaccine Influenza virus hemagglutinin neutralizing antibody virus antibody chemistry genetics human immunological tolerance immunology Influenza A virus (H1N1)Influenza A virus (H3N2)mutation Antibodies, Neutralizing Antibodies, Viral Hemagglutinin Glycoproteins, Influenza Virus Humans Immune Tolerance Immunodominant Epitopes Influenza A Virus, H1N1 Subtype Influenza A Virus, H3N2 Subtype Influenza Vaccines Mutation
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133415
推荐引用方式 GB/T 7714	Wu N.C.,Thompson A.J.,Lee J.M.,et al. Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses[J]. Science,2020,368(6497).
APA	Wu N.C..,Thompson A.J..,Lee J.M..,Su W..,Arlian B.M..,...&Wilson I.A..(2020).Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses.,368(6497).
MLA	Wu N.C.,et al."Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses".368.6497(2020).