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Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Gao Y.;  Yan L.;  Huang Y.;  Liu F.;  Zhao Y.;  Cao L.;  Wang T.;  Sun Q.;  Ming Z.;  Zhang L.;  Ge J.;  Zheng L.;  Zhang Y.;  Wang H.;  Zhu Y.;  Zhu C.;  Hu T.;  Hua T.;  Zhang B.;  Yang X.;  Li J.;  Yang H.;  Liu Z.;  Xu W.;  Guddat L.W.;  Wang Q.;  Lou Z.;  Rao Z.
收藏  |  浏览/下载:38/0  |  提交时间:2020/07/28
comparative study  drug  electron microscopy  enzyme  enzyme activity  RNA  virus  Coronavirus  SARS coronavirus  adenosine phosphate  alanine  antivirus agent  NSP7 protein, SARS-CoV-2  NSP8 protein, SARS-CoV-2  remdesivir  RNA directed RNA polymerase  RNA-dependent RNA polymerase, coronavirus  viral protein  beta sheet  Betacoronavirus  chemistry  cryoelectron microscopy  drug design  enzyme active site  enzymology  metabolism  molecular model  protein domain  ultrastructure  Adenosine Monophosphate  Alanine  Antiviral Agents  Betacoronavirus  Catalytic Domain  Cryoelectron Microscopy  Drug Design  Models, Molecular  Protein Conformation, beta-Strand  Protein Domains  RNA Replicase  Viral Nonstructural Proteins  
Cysteine depletion induces pancreatic tumor ferroptosis in mice 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者:  Badgley M.A.;  Kremer D.M.;  Carlo Maurer H.;  DelGiorno K.E.;  Lee H.-J.;  Purohit V.;  Sagalovskiy I.R.;  Ma A.;  Kapilian J.;  Firl C.E.M.;  Decker A.R.;  Sastra S.A.;  Palermo C.F.;  Andrade L.R.;  Sajjakulnukit P.;  Zhang L.;  Tolstyka Z.P.;  Hirschhorn T.;  Lamb C.;  Liu T.;  Gu W.;  Scott Seeley E.;  Stone E.;  Georgiou G.;  Manor U.;  Iuga A.;  Wahl G.M.;  Stockwell B.R.;  Lyssiotis C.A.;  Olive K.P.
收藏  |  浏览/下载:31/0  |  提交时间:2020/07/28
coenzyme A  cysteine  glutathione  amino acid  induced response  rodent  tumor  animal experiment  animal model  animal tissue  Article  cell death  cell survival  cell viability  controlled study  down regulation  ferroptosis  fragmentation reaction  human  human cell  lipid oxidation  lipophilicity  mouse  necroptosis  nonhuman  pancreas tumor  pancreatic ductal carcinoma cell line  priority journal  protein cleavage  protein expression  tumor growth  tumor microenvironment  tumor xenograft  Mus