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In a Field Where Smaller Is Better, Researchers Discover the World's Tiniest Antibodies 科技资讯
2020
收藏  |  浏览/下载：1/0  |  提交时间：2022/01/11
Combination prevention for COVID-19 期刊论文
Science, 2020, 卷号: 368, 期号: 6491
作者:  Cohen M.S.;  Corey L.
收藏  |  浏览/下载：1/0  |  提交时间：2022/01/14
REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters 期刊论文
Science, 2020, 卷号: 370, 期号: 6520
作者:  Baum A.;  Ajithdoss D.;  Copin R.;  Zhou A.;  Lanza K.;  Negron N.;  Ni M.;  Wei Y.;  Mohammadi K.;  Musser B.;  Atwal G.S.;  Oyejide A.;  Goez-Gazi Y.;  Dutton J.;  Clemmons E.;  Staples H.M.;  Bartley C.;  Klaffke B.;  Alfson K.;  Gazi M.;  Gonzalez O.;  Dick E.;  Jr.;  Carrion R.;  Jr.;  Pessaint L.;  Porto M.;  Cook A.;  Brown R.;  Ali V.;  Greenhouse J.;  Taylor T.;  Andersen H.;  Lewis M.G.;  Stahl N.;  Murphy A.J.;  Yancopoulos G.D.;  Kyratsous C.A.
收藏  |  浏览/下载：20/0  |  提交时间：2022/01/14
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  ElTanbouly M.A.;  Zhao Y.;  Nowak E.;  Li J.;  Schaafsma E.;  Le Mercier I.;  Ceeraz S.;  Lines J.L.;  Peng C.;  Carriere C.;  Huang X.;  Day M.;  Koehn B.;  Lee S.W.;  Morales M.S.;  Hogquist K.A.;  Jameson S.C.;  Mueller D.;  Rothstein J.;  Blazar B.R.;  Cheng C.;  Noelle R.J.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
cell protein  interferon  kruppel like factor 2  T lymphocyte receptor  unclassified drug  V type immunoglobulin domain containing suppressor of T cell activation protein  B7 antigen  Dies1 protein, mouse  lymphocyte antigen receptor  membrane protein  monoclonal antibody  VSIR protein, human  biological development  cell  gene expression  heterogeneity  homeostasis  immune response  immunity  tolerance  acute graft versus host disease  animal cell  animal experiment  animal model  Article  CD4+ T lymphocyte  cell death  cell expansion  cell fate  cell heterogeneity  cell loss  cell survival  controlled study  female  gene  gene deletion  homeostasis  immunological tolerance  in vivo study  long term survival  male  mouse  nonhuman  phenotype  priority journal  protein expression  protein function  rheumatoid arthritis  RNA sequencing  systemic lupus erythematosus  T lymphocyte  T lymphocyte activation  T lymphocyte subpopulation  TCR gene  upregulation  VISTA gene  animal  C57BL mouse  genetics  immunological tolerance  immunology  knockout mouse  lymphocyte activation  physiology  T lymphocyte  Mus  Animals  Antibodies, Monoclonal  B7 Antigens  Lymphocyte Activation  Membrane Proteins  Mice  Mice, Inbred C57BL  Mice, Knockout  Peripheral Tolerance  Receptors, Antigen, T-Cell  T-Lymphocytes  
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Wu Y.;  Wang F.;  Shen C.;  Peng W.;  Li D.;  Zhao C.;  Li Z.;  Li S.;  Bi Y.;  Yang Y.;  Gong Y.;  Xiao H.;  Fan Z.;  Tan S.;  Wu G.;  Tan W.;  Lu X.;  Fan C.;  Wang Q.;  Liu Y.;  Zhang C.;  Qi J.;  Gao G.F.;  Gao F.;  Liu L.
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/28
Coronavirus  angiotensin converting enzyme 2  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  monoclonal antibody  neutralizing antibody  virus antibody  virus receptor  animal  chemistry  Coronavirus infection  disease model  human  immunology  isolation and purification  lung  mouse  pandemic  protein domain  serodiagnosis  virology  virus load  virus pneumonia  Animals  Antibodies, Monoclonal  Antibodies, Neutralizing  Antibodies, Viral  Coronavirus Infections  Disease Models, Animal  Humans  Immunodominant Epitopes  Lung  Mice  Neutralization Tests  Pandemics  Peptidyl-Dipeptidase A  Pneumonia, Viral  Protein Domains  Receptors, Virus  Spike Glycoprotein, Coronavirus  Viral Load  
Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:  Rougé L.;  Chiang N.;  Steffek M.;  Kugel C.;  Croll T.I.;  Tam C.;  Estevez A.;  Arthur C.P.;  Koth C.M.;  Ciferri C.;  Kraft E.;  Payandeh J.;  Nakamura G.;  Koerber J.T.;  Rohou A.
收藏  |  浏览/下载：14/0  |  提交时间：2020/07/28
CD20 antigen  dimer  epitope  Fc receptor  immunoglobulin F(ab) fragment  obinutuzumab  ocrelizumab  ofatumumab  rituximab  tositumomab i 131  antibody  antigen  cell  chemical binding  composite  gene expression  genetic marker  protein  amino acid sequence  antibody dependent cellular cytotoxicity  antigen antibody complex  antigen binding  antigen structure  Article  cell death  cell surface  chemical bond  complement dependent cytotoxicity  drug protein binding  drug targeting  electron microscopy  human  humoral immune deficiency  insect cell  lipid raft  malignant neoplasm  molecular recognition  multiple sclerosis  nonhuman  phagocytosis  priority journal  protein cross linking  protein interaction  stoichiometry  surface plasmon resonance  
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:  Wrapp D.;  Wang N.;  Corbett K.S.;  Goldsmith J.A.;  Hsieh C.-L.;  Abiona O.;  Graham B.S.;  McLellan J.S.
收藏  |  浏览/下载：31/0  |  提交时间：2020/07/28
2019 nCoV S protein  angiotensin converting enzyme 2  unclassified drug  viral protein  angiotensin converting enzyme 2  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  monoclonal antibody  protein binding  severe acute respiratory syndrome coronavirus 2  virus antibody  virus receptor  antibody  detection method  electron microscopy  protein  public health  severe acute respiratory syndrome  virus  Article  binding affinity  biophysics  corona virus disease 2019  coronavirus disease 2019  Coronavirus infection  cross reaction  cryoelectron microscopy  molecular dynamics  nonhuman  priority journal  protein binding  protein structure  SARS coronavirus  Severe acute respiratory syndrome coronavirus 2  virus transmission  virus virulence  Betacoronavirus  chemistry  cryoelectron microscopy  image processing  immunology  metabolism  molecular model  protein conformation  protein domain  protein multimerization  ultrastructure  Coronavirus  SARS coronavirus  Antibodies, Monoclonal  Antibodies, Viral  Betacoronavirus  Cross Reactions  Cryoelectron Microscopy  Image Processing, Computer-Assisted  Models, Molecular  Peptidyl-Dipeptidase A  Protein Binding  Protein Conformation  Protein Domains  Protein Multimerization  Receptors, Virus  SARS Virus  Spike Glycoprotein, Coronavirus