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| THE SUOMI NPP SCIENCE DATA SEGMENT ATMOSPHERE PRODUCT EVALUATION AND ALGORITHM TEST ELEMENT (PEATE): POST-LAUNCH CONTINUATION | |
| 项目编号 | NNX13AO09G S03 |
| LIAM E GUMLEY | |
| 项目主持机构 | UNIVERSITY OF WISCONSIN - MADISON |
| 开始日期 | 2013-10-01 |
| 结束日期 | 2015-08-31 |
| 英文摘要 | This project will provide a significantly improved method for intra-pulmonary drug delivery in pediatric patients who are intubated or have a tracheostomy. Currently available aerosolizing devices are limited in that only certain agents and only a small fraction (less than a few percent) of such drugs are actually delivered to the distal lung zones. We propose a novel Intra-Pulmonary Aerosol Generator (IPAG), which would be a 1 or 2 mm diameter tube inserted within the endotracheal tube. This IPAG will be capable of generating micro- aerosols that would reach the remote airways and alveoli with an efficiency approaching 100%. Further, our device is unique in that it uses extremely low airflow to generate respirable aerosols to minimize any potential barotrauma. Moreover, this aerosolizer can be synchronized to the inspiratory phase of the ventilator cycle without the introduction of significant resistance within the flow circuit. A broad range of ventilated pediatric patients fro a variety of etiologies including pneumonia, acute lung injury and acute respiratory distress syndrome would benefit from our proposed aerosol generator. IPAG would enable delivery of agents such as, antibiotics (for treatment of pneumonia and sepsis), as well as glucose, steroids, analgesics, and sedatives. IPAG allows for a simple means of essential drug delivery during resuscitation of patients and bypasses the immediate need for intravenous access. This is of particular utility in neonatal resuscitation and during transport of such infants from rural centers where intravenous access can be challenging and difficult. The core technology for the proposed device has been developed by Powerscope and is being used in preclinical work involving aerosol generation in vitrectomized gas-filled porcine eyes for inhibition of scar tissue growth caused by retinal detachment. We propose to translate and develop this technology into a feasible product that can be synchronized to ventilation and complement airflow dynamics. Aerosol generation and particle size distribution will be characterized with in-vitro models. Neonatal lamb model will be used to quantify pulmonary distribution, and systemic bio-absorption of aerosolized antibiotics delivered with IPAG. Completion of this Phase I SBIR project would prepare the grounds for efficacy studies with animal models of pneumonia and acute lung injury in the Phase II project with further safety studies in order to prepare the devic for future clinical trials. |
| 英文关键词 | absorption;Acute Pneumonia;Address;Adult Respiratory Distress Syndrome;aerosolized;Aerosols;Air;Alveolus;Analgesics;Animal Model;Animals;Antibiotic Therapy;Antibiotics;Biodistribution;Bolus Infusion;Breathing;Bypass;Caliber;Catheters;Characteristics;Childhood;Cicatrix;Clinical Trials;Complement;Critical Illness;Deposition;design;Development;Device or Instrument Development;Devices;Distal;drug clearance;Drug Delivery Systems;Dysbarism;endotracheal;Ensure;Environmental air flow;Essential Drugs;Etiology;Eye;Family suidae;flexibility;Future;Gamma Cameras;Gases;Generations;Glucose;Growth;Healthcare;improved;in vitro Model;in vitro testing;in vivo;Infant;Inhalation Device;Intravenous;Label;Legal patent;Liquid substance;Lung;Lung Injury, Acute;Metabolic Clearance Rate;Methods;Modeling;Neonatal;neonatal resuscitation;novel;operation;particle;Particle Size;Patients;Penetration;Pharmaceutical Preparations;Phase;Pneumonia;pre-clinical;Premature Infant;Property;public health medicine (field);public health relevance;Radio;Radionuclide Imaging;Relative (related person);research study;Resistance;respiratory distress syndrome;Respiratory System;Respiratory tract structure;Resuscitation;Retinal Detachment;Rural;safety study;sedative;Sepsis;septic;Small Business Innovation Research Grant;Steroids;success;surfactant;Technology;Tracheostomy procedure;Tracheostomy Tube;Translating;Transportation;Tube;Ventilator;Work |
| 学科分类 | 08 - 地球科学;11 - 工程与技术;1107 - 航空航天工程;03 - 天文学 |
| 资助机构 | US-NASA |
| 国家 | US |
| 语种 | 英语 |
| 文献类型 | 项目 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/74839 |
| 推荐引用方式 GB/T 7714 | LIAM E GUMLEY.THE SUOMI NPP SCIENCE DATA SEGMENT ATMOSPHERE PRODUCT EVALUATION AND ALGORITHM TEST ELEMENT (PEATE): POST-LAUNCH CONTINUATION.2013. |
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