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De novo protein design enables the precise induction of RSV-neutralizing antibodies 期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:  Sesterhenn F.;  Yang C.;  Bonet J.;  Cramer J.T.;  Wen X.;  Wang Y.;  Chiang C.-I.;  Abriata L.A.;  Kucharska I.;  Castoro G.;  Vollers S.S.;  Galloux M.;  Dheilly E.;  Rosset S.;  Corthésy P.;  Georgeon S.;  Villard M.;  Richard C.-A.;  Descamps D.;  Delgado T.;  Oricchio E.;  Rameix-Welti M.-A.;  Más V.;  Ervin S.;  Eléouët J.-F.;  Riffault S.;  Bates J.T.;  Julien J.-P.;  Li Y.;  Jardetzky T.;  Krey T.;  Correia B.E.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
algorithm  antibody  design  neutralization  protein  vaccine  Mus  Primates  Respiratory syncytial virus  Rice stripe virus  epitope  fusion protein  nanobody  neutralizing antibody  respiratory syncytial virus vaccine  biology  biosynthesis  chemistry  human  Human respiratory syncytial virus  immunology  procedures  protein conformation  protein engineering  protein motif  Amino Acid Motifs  Antibodies, Neutralizing  Computational Biology  Humans  Immunodominant Epitopes  Protein Conformation  Protein Engineering  Recombinant Fusion Proteins  Respiratory Syncytial Virus Vaccines  Respiratory Syncytial Virus, Human  Single-Domain Antibodies  
TTC5 mediates autoregulation of tubulin via mRNA degradation 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者:  Lin Z.;  Gasic I.;  Chandrasekaran V.;  Peters N.;  Shao S.;  Mitchison T.J.;  Hegde R.S.
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/28
messenger RNA  mutant protein  polypeptide  recombinant protein  regulator protein  tetratricopeptide protein 5  tubulin  unclassified drug  biodegradation  chromosome  peptide  protein  RNA  amino terminal sequence  animal cell  Article  autoregulation  binding site  chromosome segregation  controlled study  cryoelectron microscopy  genetic code  human  human cell  Leporidae  mitosis  molecular model  nonhuman  priority journal  protein analysis  protein binding  protein interaction  protein structure  reticulocyte  ribosome  RNA degradation  RNA translation  tubulin gene  
The histone H3-H4 tetramer is a copper reductase enzyme 期刊论文
, 2020, 卷号: 369, 期号: 6499
作者:  Attar N.;  Campos O.A.;  Vogelauer M.;  Cheng C.;  Xue Y.;  Schmollinger S.;  Salwinski L.;  Mallipeddi N.V.;  Boone B.A.;  Yen L.;  Yang S.;  Zikovich S.;  Dardine J.;  Carey M.F.;  Merchant S.S.;  Kurdistani S.K.
收藏  |  浏览/下载：28/0  |  提交时间：2020/07/28
copper  copper oxidase  copper zinc superoxide dismutase  histone  MAC1 protein, S cerevisiae  nuclear protein  oxidoreductase  recombinant protein  Saccharomyces cerevisiae protein  transcription factor  animal  biocatalysis  chemistry  enzyme active site  enzymology  gain of function mutation  genetics  metabolism  mitochondrion  protein multimerization  Saccharomyces cerevisiae  Xenopus laevis  Animals  Biocatalysis  Catalytic Domain  Copper  Gain of Function Mutation  Histones  Mitochondria  Nuclear Proteins  Oxidoreductases  Protein Multimerization  Recombinant Proteins  Saccharomyces cerevisiae  Saccharomyces cerevisiae Proteins  Superoxide Dismutase-1  Transcription Factors  Xenopus laevis  
Partitioning of cancer therapeutics in nuclear condensates 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Klein I.A.;  Boija A.;  Afeyan L.K.;  Hawken S.W.;  Fan M.;  Dall'Agnese A.;  Oksuz O.;  Henninger J.E.;  Shrinivas K.;  Sabari B.R.;  Sagi I.;  Clark V.E.;  Platt J.M.;  Kar M.;  McCall P.M.;  Zamudio A.V.;  Manteiga J.C.;  Coffey E.L.;  Li C.H.;  Hannett N.M.;  Guo Y.E.;  Decker T.-M.;  Lee T.I.;  Zhang T.;  Weng J.-K.;  Taatjes D.J.;  Chakraborty A.;  Sharp P.A.;  Chang Y.T.;  Hyman A.A.;  Gray N.S.;  Young R.A.
收藏  |  浏览/下载：39/0  |  提交时间：2020/07/28
cancer  condensate  disease  drug  physicochemical property  protein  tumor  antineoplastic agent  BRD4 protein, human  cell cycle protein  green fluorescent protein  heterochromatin-specific nonhistone chromosomal protein HP-1  MED1 protein, human  nonhistone protein  nuclear protein  nucleophosmin  peroxisome proliferator activated receptor binding protein  recombinant protein  serine arginine rich splicing factor  SRSF2 protein, human  transcription factor  cell nucleus  drug resistance  genetics  human  metabolism  neoplasm  Antineoplastic Agents  Cell Cycle Proteins  Cell Nucleus  Chromosomal Proteins, Non-Histone  Drug Resistance, Neoplasm  Green Fluorescent Proteins  Humans  Mediator Complex Subunit 1  Neoplasms  Nuclear Proteins  Recombinant Proteins  Serine-Arginine Splicing Factors  Transcription Factors  
Structure of an active human histone pre-mRNA 3′-end processing machinery 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Sun Y.;  Zhang Y.;  Aik W.S.;  Yang X.-C.;  Marzluff W.F.;  Walz T.;  Dominski Z.;  Tong L.
收藏  |  浏览/下载：208/0  |  提交时间：2020/07/28
beta lactamase  cleavage and polyadenylation specificity factor  cleavage and polyadenylation specificity factor 100  cleavage and polyadenylation specificity factor 73  endonuclease  histone  membrane protein  messenger RNA precursor  recombinant protein  small nuclear ribonucleoprotein  small nuclear RNA  symplekin  U7 small nuclear ribonucleoprotein  unclassified drug  enzyme activity  genetic analysis  metazoan  protein  recombination  RNA  3' untranslated region  amino terminal sequence  Article  biochemical analysis  carboxy terminal sequence  conformational transition  controlled study  cryoelectron microscopy  enzyme active site  gene rearrangement  genetic analysis  hydrogen bond  molecular recognition  mutagenesis  polyadenylation  priority journal  protein conformation  protein protein interaction  RNA cleavage  RNA processing  RNA sequencing  Amphora  Metazoa