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Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Walton R.T.;  Christie K.A.;  Whittaker M.N.;  Kleinstiver B.P.
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/28
adenine  adenosine  CRISPR associated endonuclease Cas9  cytosine  guanosine  SpG protein  SpRY nuclease  thymine  unclassified drug  Cas9 endonuclease Streptococcus pyogenes  bacterium  enzyme activity  genetic engineering  genetic variation  genome  Article  CRISPR-CAS9 system  DNA sequence  enzyme activity  gene editing  gene targeting  genetic variability  human  mutagenesis  nonhuman  priority journal  protein engineering  protein motif  protein structure  protospacer adjacent motif  Streptococcus pyogenes  chemistry  CRISPR Cas system  enzyme specificity  gene editing  gene targeting  genetic predisposition  genetics  HEK293 cell line  procedures  protein domain  Streptococcus pyogenes  CRISPR-Associated Protein 9  CRISPR-Cas Systems  Gene Editing  Gene Targeting  Genetic Predisposition to Disease  HEK293 Cells  Humans  Mutagenesis  Protein Domains  Substrate Specificity  
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Pareek V.;  Tian H.;  Winograd N.;  Benkovic S.J.
收藏  |  浏览/下载：35/0  |  提交时间：2020/07/28
adenosine phosphate  guanosine phosphate  multienzyme complex  nucleotide  purine  purine  purine derivative  cell  experimental study  imaging method  mass spectrometry  metabolism  protein  Article  biochemistry  enzyme assay  gas cluster ion beam secondary ion mass spectrometry  image analysis  mass spectrometry  metabolomics  mitochondrion  molecular imaging  molecular probe  priority journal  purine synthesis  reaction analysis  single cell analysis  biosynthesis  fluorescence imaging  HeLa cell line  human  metabolism  metabolomics  procedures  secondary ion mass spectrometry  HeLa Cells  Humans  Metabolomics  Mitochondria  Multienzyme Complexes  Optical Imaging  Purines  Single-Cell Analysis  Spectrometry, Mass, Secondary Ion  
Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Wang J.;  Li P.;  Yu Y.;  Fu Y.;  Jiang H.;  Lu M.;  Sun Z.;  Jiang S.;  Lu L.;  Wu M.X.
收藏  |  浏览/下载：43/0  |  提交时间：2020/07/28
2',3' cyclic guanosine monophosphate adenosine monophosphate  influenza vaccine  interferon  nanoparticle  pulmonary surfactant biomimetic nanoparticle  purine nucleotide  surfactant protein A  surfactant protein D  unclassified drug  cell  drug resistance  immune response  immunity  induced response  influenza  nanoparticle  rodent  surfactant  vaccine  animal cell  animal experiment  animal model  animal tissue  Article  CD8+ T lymphocyte  cellular immunity  controlled study  cross protection  cytokine response  drug efficacy  drug safety  drug synthesis  female  human  humoral immunity  hydrophilicity  immune response  immunopathology  immunosurveillance  influenza  innate immunity  lung alveolus epithelium cell  lung alveolus macrophage  mouse  Mustela putorius furo  nanoencapsulation  nonhuman  priority journal  Mus  Mustela  
Structural basis for transcriptional start site control of HIV-1 RNA fate 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Brown J.D.;  Kharytonchyk S.;  Chaudry I.;  Iyer A.S.;  Carter H.;  Becker G.;  Desai Y.;  Glang L.;  Choi S.H.;  Singh K.;  Lopresti M.W.;  Orellana M.;  Rodriguez T.;  Oboh U.;  Hijji J.;  Ghinger F.G.;  Stewart K.;  Francis D.;  Edwards B.;  Chen P.;  Case D.A.;  Telesnitsky A.;  Summers M.F.
收藏  |  浏览/下载：41/0  |  提交时间：2020/07/28
capped RNA  initiation factor 4E  messenger RNA  virus RNA  capped RNA  guanosine  initiation factor 4E  messenger RNA  virus RNA  cell  chemical binding  deuterium  genome  human immunodeficiency virus  physiological response  RNA  Article  base pairing  deuteron nuclear magnetic resonance  dimerization  DNA helix  energy transfer  gene control  gene function  gene number  human  Human immunodeficiency virus 1  nonhuman  priority journal  promoter region  RNA probe  RNA structure  RNA transcription  virus replication  5' untranslated region  base pairing  chemistry  DNA base composition  gene expression regulation  genetics  Human immunodeficiency virus 1  metabolism  nuclear magnetic resonance  protein synthesis  transcription initiation site  Eukaryota  Human immunodeficiency virus 1  5' Untranslated Regions  Base Composition  Base Pairing  Eukaryotic Initiation Factor-4E  Gene Expression Regulation, Viral  Guanosine  HIV-1  Humans  Nuclear Magnetic Resonance, Biomolecular  Protein Biosynthesis  RNA Caps  RNA, Messenger  RNA, Viral  Transcription Initiation Site