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| Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者: Walton R.T.; Christie K.A.; Whittaker M.N.; Kleinstiver B.P.
  收藏 | 浏览/下载：20/0 | 提交时间：2020/07/28
adenine adenosine CRISPR associated endonuclease Cas9 cytosine guanosine SpG protein SpRY nuclease thymine unclassified drug Cas9 endonuclease Streptococcus pyogenes bacterium enzyme activity genetic engineering genetic variation genome Article CRISPR-CAS9 system DNA sequence enzyme activity gene editing gene targeting genetic variability human mutagenesis nonhuman priority journal protein engineering protein motif protein structure protospacer adjacent motif Streptococcus pyogenes chemistry CRISPR Cas system enzyme specificity gene editing gene targeting genetic predisposition genetics HEK293 cell line procedures protein domain Streptococcus pyogenes CRISPR-Associated Protein 9 CRISPR-Cas Systems Gene Editing Gene Targeting Genetic Predisposition to Disease HEK293 Cells Humans Mutagenesis Protein Domains Substrate Specificity |
| Single-cell transcriptional diversity is a hallmark of developmental potential 期刊论文
, 2020, 卷号: 367, 期号: 6476
作者: Gulati G.S.; Sikandar S.S.; Wesche D.J.; Manjunath A.; Bharadwaj A.; Berger M.J.; Ilagan F.; Kuo A.H.; Hsieh R.W.; Cai S.; Zabala M.; Scheeren F.A.; Lobo N.A.; Qian D.; Yu F.B.; Dirbas F.M.; Clarke M.F.; Newman A.M.
收藏 | 浏览/下载：38/0 | 提交时间：2020/07/28
cell cell component developmental biology experimental study genetic analysis tumor Article breast cancer breast carcinogenesis carcinogenesis cell differentiation computer model embryonic stem cell gene expression genetic code genetic variability human in vivo study nonhuman phenotype priority journal scoring system single cell RNA seq upregulation |
| The genetic architecture of the human cerebral cortex 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者: Grasby K.L.; Jahanshad N.; Painter J.N.; Colodro-Conde L.; Bralten J.; Hibar D.P.; Lind P.A.; Pizzagalli F.; Ching C.R.K.; McMahon M.A.B.; Shatokhina N.; Zsembik L.C.P.; Thomopoulos S.I.; Zhu A.H.; Strike L.T.; Agartz I.; Alhusaini S.; Almeida M.A.A.; Alnæs D.; Amlien I.K.; Andersson M.; Ard T.; Armstrong N.J.; Ashley-Koch A.; Atkins J.R.; Bernard M.; Brouwer R.M.; Buimer E.E.L.; Bülow R.; Bürger C.; Cannon D.M.; Chakravarty M.; Chen Q.; Cheung J.W.; Couvy-Duchesne B.; Dale A.M.; Dalvie S.; de Araujo T.K.; de Zubicaray G.I.; de Zwarte S.M.C.; den Braber A.; Doan N.T.; Dohm K.; Ehrlich S.; Engelbrecht H.-R.; Erk S.; Fan C.C.; Fedko I.O.; Foley S.F.; Ford J.M.; Fukunaga M.; Garrett M.E.; Ge T.; Giddaluru S.; Goldman A.L.; Green M.J.; Groenewold N.A.; Grotegerd D.; Gurholt T.P.; Gutman B.A.; Hansell N.K.; Harris M.A.; Harrison M.B.; Haswell C.C.; Hauser M.; Herms S.; Heslenfeld D.J.; Ho N.F.; Hoehn D.; Hoffmann P.; Holleran L.; Hoogman M.; Hottenga J.-J.; Ikeda M.; Janowitz D.; Jansen I.E.; Jia T.; Jockwitz C.; Kanai R.; Karama S.; Kasperaviciute D.; Kaufmann T.; Kelly S.; Kikuchi M.; Klein M.; Knapp M.; Knodt A.R.; Krämer B.; Lam M.; Lancaster T.M.; Lee P.H.; Lett T.A.; Lewis L.B.; Lopes-Cendes I.; Luciano M.; Macciardi F.; Marquand A.F.; Mathias S.R.; Melzer T.R.; Milaneschi Y.; Mirza-Schreiber N.; Moreira J.C.V.; Mühleisen T.W.; Müller-Myhsok B.; Najt P.; Nakahara S.; Nho K.; Olde Loohuis L.M.; Orfanos D.P.; Pearson J.F.; Pitcher T.L.; Pütz B.; Quidé Y.; Ragothaman A.; Rashid F.M.; Reay W.R.; Redlich R.; Reinbold C.S.; Repple J.; Richard G.; Riedel B.C.; Risacher S.L.; Rocha C.S.; Mota N.R.; Salminen L.; Saremi A.; Saykin A.J.; Schlag F.; Schmaal L.; Schofield P.R.; Secolin R.; Shapland C.Y.; Shen L.; Shin J.; Shumskaya E.; Sønderby I.E.; Sprooten E.; Tansey K.E.; Teumer A.; Thalamuthu A.; Tordesillas-Gutiérrez D.; Turner J.A.; Uhlmann A.; Vallerga C.L.; van der Meer D.; van Donkelaar M.M.J.; van Eijk L.; van Erp T.G.M.; van Haren N.E.M.; van Rooij D.; van Tol M.-J.; Veldink J.H.; Verhoef E.; Walton E.; Wang M.; Wang Y.; Wardlaw J.M.; Wen W.; Westlye L.T.; Whelan C.D.; Witt S.H.; Wittfeld K.; Wolf C.; Wolfers T.; Wu J.Q.; Yasuda C.L.; Zaremba D.; Zhang Z.; Zwiers M.P.; Artiges E.; Assareh A.A.; Ayesa-Arriola R.; Belger A.; Brandt C.L.; Brown G.G.; Cichon S.; Curran J.E.; Davies G.E.; Degenhardt F.; Dennis M.F.; Dietsche B.; Djurovic S.; Doherty C.P.; Espiritu R.; Garijo D.; Gil Y.; Gowland P.A.; Green R.C.; Häusler A.N.; Heindel W.; Ho B.-C.; Hoffmann W.U.; Holsboer F.; Homuth G.; Hosten N.; Jack C.R.; Jang M.; Jansen A.; Kimbrel N.A.; Kolskår K.; Koops S.; Krug A.; Lim K.O.; Luykx J.J.; Mathalon D.H.; Mather K.A.; Mattay V.S.; Matthews S.; van Son J.M.; McEwen S.C.; Melle I.; Morris D.W.; Mueller B.A.; Nauck M.; Nordvik J.E.; Nöthen M.M.; O'Leary D.S.; Opel N.; Martinot M.-L.P.; Bruce Pike G.; Preda A.; Quinlan E.B.; Rasser P.E.; Ratnakar V.; Reppermund S.; Steen V.M.; Tooney P.A.; Torres F.R.; Veltman D.J.; Voyvodic J.T.; Whelan R.; White T.; Yamamori H.; Adams H.H.H.; Bis J.C.; Debette S.; Decarli C.; Fornage M.; Gudnason V.; Hofer E.; Arfan Ikram M.; Launer L.; Longstreth W.T.; Lopez O.L.; Mazoyer B.; Mosley T.H.; Roshchupkin G.V.; Satizabal C.L.; Schmidt R.; Seshadri S.; Yang Q.; Alvim M.K.M.; Ames D.; Anderson T.J.; Andreassen O.A.; Arias-Vasquez A.; Bastin M.E.; Baune B.T.; Beckham J.C.; Blangero J.; Boomsma D.I.; Brodaty H.; Brunner H.G.; Buckner R.L.; Buitelaar J.K.; Bustillo J.R.; Cahn W.; Cairns M.J.; Calhoun V.; Carr V.J.; Caseras X.; Caspers S.; Cavalleri G.L.; Cendes F.; Corvin A.; Crespo-Facorro B.; Dalrymple-Alford J.C.; Dannlowski U.; de Geus E.J.C.; Deary I.J.; Delanty N.; Depondt C.; Desrivières S.; Donohoe G.; Espeseth T.; Fernández G.; Fisher S.E.; Flor H.; Forstner A.J.; Francks C.; Franke B.; Glahn D.C.; Gollub R.L.; Grabe H.J.; Gruber O.; Håberg A.K.; Hariri A.R.; Hartman C.A.; Hashimoto R.; Heinz A.; Henskens F.A.; Hillegers M.H.J.; Hoekstra P.J.; Holmes A.J.; Elliot Hong L.; Hopkins W.D.; Hulshoff Pol H.E.; Jernigan T.L.; Jönsson E.G.; Kahn R.S.; Kennedy M.A.; Kircher T.T.J.; Kochunov P.; Kwok J.B.J.; Le Hellard S.; Loughland C.M.; Martin N.G.; Martinot J.-L.; McDonald C.; McMahon K.L.; Meyer-Lindenberg A.; Michie P.T.; Morey R.A.; Mowry B.; Nyberg L.; Oosterlaan J.; Ophoff R.A.; Pantelis C.; Paus T.; Pausova Z.; Penninx B.W.J.H.; Polderman T.J.C.; Posthuma D.; Rietschel M.; Roffman J.L.; Rowland L.M.; Sachdev P.S.; Sämann P.G.; Schall U.; Schumann G.; Scott R.J.; Sim K.; Sisodiya S.M.; Smoller J.W.; Sommer I.E.; Pourcain B.S.; Stein D.J.; Toga A.W.; Trollor J.N.; van der Wee N.J.A.; van't Ent D.; Völzke H.; Walter H.; Weber B.; Weinberger D.R.; Wright M.J.; Zhou J.; Stein J.L.; Thompson P.M.; Medland S.E.; Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group
收藏 | 浏览/下载：48/0 | 提交时间：2020/07/28
brain genetic analysis meta-analysis resonance signaling surface area Article bioinformatics brain cortex brain function brain region brain tissue cortical thickness (brain) educational status evidence based medicine gene control gene locus genetic association genetic correlation genetic variability genome-wide association study human human genetics priority journal surface area tissue structure Wnt signaling anatomy and histology attention deficit disorder brain cortex brain mapping cognition genetic variation genetics meta analysis nuclear magnetic resonance imaging organ size Parkinson disease Attention Deficit Disorder with Hyperactivity Brain Mapping Cerebral Cortex Cognition Genetic Loci Genetic Variation Genome-Wide Association Study Humans Magnetic Resonance Imaging Organ Size Parkinson Disease |
| The evolutionary dynamics and fitness landscape of clonal hematopoiesis 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者: Watson C.J.; Papula A.L.; Poon G.Y.P.; Wong W.H.; Young A.L.; Druley T.E.; Fisher D.S.; Blundell J.R.
收藏 | 浏览/下载：21/0 | 提交时间：2020/07/28
DNA methyltransferase 3A blood cancer evolutionary biology fitness gene expression genetic drift hematology mutation pathogenicity acute myeloid leukemia age distribution allele Article cancer risk cell expansion cell population clonal hematopoiesis epigenetics gene mutation genetic variability hematological parameters hematopoiesis hematopoietic stem cell human molecular evolution mutational analysis nonhuman priority journal single nucleotide polymorphism somatic mutation stem cell self-renewal |
| Genetics of schizophrenia in the South African Xhosa 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者: Gulsuner S.; Stein D.J.; Susser E.S.; Sibeko G.; Pretorius A.; Walsh T.; Majara L.; Mndini M.M.; Mqulwana S.G.; Ntola O.A.; Casadei S.; Ngqengelele L.L.; Korchina V.; Van Der Merwe C.; Malan M.; Fader K.M.; Feng M.; Willoughby E.; Muzny D.; Baldinger A.; Andrews H.F.; Gur R.C.; Gibbs R.A.; Zingela Z.; Nagdee M.; Ramesar R.S.; King M.-C.; McClellan J.M.
收藏 | 浏览/下载：34/0 | 提交时间：2020/07/28
4 aminobutyric acid dopamine glutamine genetic analysis genetic variation genome genomics mutagenicity mutation Article connectome controlled study gene mutation genetic variability genetics human major clinical study nerve cell plasticity priority journal schizophrenia South African Xhosa (people) South Africa |
