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Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Walton R.T.;  Christie K.A.;  Whittaker M.N.;  Kleinstiver B.P.
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/28
adenine  adenosine  CRISPR associated endonuclease Cas9  cytosine  guanosine  SpG protein  SpRY nuclease  thymine  unclassified drug  Cas9 endonuclease Streptococcus pyogenes  bacterium  enzyme activity  genetic engineering  genetic variation  genome  Article  CRISPR-CAS9 system  DNA sequence  enzyme activity  gene editing  gene targeting  genetic variability  human  mutagenesis  nonhuman  priority journal  protein engineering  protein motif  protein structure  protospacer adjacent motif  Streptococcus pyogenes  chemistry  CRISPR Cas system  enzyme specificity  gene editing  gene targeting  genetic predisposition  genetics  HEK293 cell line  procedures  protein domain  Streptococcus pyogenes  CRISPR-Associated Protein 9  CRISPR-Cas Systems  Gene Editing  Gene Targeting  Genetic Predisposition to Disease  HEK293 Cells  Humans  Mutagenesis  Protein Domains  Substrate Specificity  
Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  Hoffman D.P.;  Shtengel G.;  Xu C.S.;  Campbell K.R.;  Freeman M.;  Wang L.;  Milkie D.E.;  Pasolli H.A.;  Iyer N.;  Bogovic J.A.;  Stabley D.R.;  Shirinifard A.;  Pang S.;  Peale D.;  Schaefer K.;  Pomp W.;  Chang C.-L.;  Lippincott-Schwartz J.;  Kirchhausen T.;  Solecki D.J.;  Betzig E.;  Hess H.F.
收藏  |  浏览/下载：50/0  |  提交时间：2020/07/28
cell  compartmentalization  cryopreservation  electron microscopy  image resolution  protein  three-dimensional modeling  ultrastructure  article  chromatin  electron microscopy  endoplasmic reticulum  genetic transcription  human cell  mammal cell  nerve cell culture  protein domain  ultrastructure  whole cell  workflow  animal  cell adhesion  cells  Chlorocebus aethiops  cryoelectron microscopy  CV-1 cell line  fluorescence microscopy  freezing  HeLa cell line  human  mouse  procedures  three-dimensional imaging  tumor cell line  ultrastructure  Mammalia  Animals  Cell Adhesion  Cell Line, Tumor  Cells  Chlorocebus aethiops  COS Cells  Cryoelectron Microscopy  Freezing  HeLa Cells  Humans  Imaging, Three-Dimensional  Mice  Microscopy, Fluorescence  
Massively multiplex chemical transcriptomics at single-cell resolution 期刊论文
, 2020, 卷号: 367, 期号: 6473
作者:  Srivatsan S.R.;  McFaline-Figueroa J.L.;  Ramani V.;  Saunders L.;  Cao J.;  Packer J.;  Pliner H.A.;  Jackson D.L.;  Daza R.M.;  Christiansen L.;  Zhang F.;  Steemers F.;  Shendure J.;  Trapnell C.
收藏  |  浏览/下载：20/0  |  提交时间：2020/07/28
4 (2 aminoethylamino) 1,8 dimethylimidazo[1,2 a]quinoxaline  abexinostat  acetic acid  belinostat  cudc 101  fimepinostat  givinostat  histone deacetylase inhibitor  m 344  n [2 [3 (1 piperazinylmethyl)imidazo[2,1 b]thiazol 6 yl]phenyl] 2 quinoxalinecarboxamide  panobinostat  pracinostat  rec 2282  trametinib  transcriptome  trichostatin A  unclassified drug  transcriptome  cancer  cell  chemical analysis  detection method  experimental study  genetic analysis  resolution  A-549 cell line  animal cell  animal experiment  Article  cell function  cell heterogeneity  cell labeling  cell proliferation  chromatin  controlled study  dose response  drug activity  experimentation  gene control  genetic transcription  human  human cell  K-562 cell line  MCF-7 cell line  mouse  nonhuman  pilot study  priority journal  proof of concept  RNA sequence  screening  single cell analysis  transcriptomics  cell nucleus  drug effect  genetics  genomics  high throughput screening  metabolism  neoplasm  procedures  single cell analysis  A549 Cells  Acetates  Cell Nucleus  Chromatin  Genomics  High-Throughput Screening Assays  Histone Deacetylase Inhibitors  Humans  K562 Cells  MCF-7 Cells  Neoplasms  RNA-Seq  Single-Cell Analysis  Transcriptome  
Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:  Battich N.;  Beumer J.;  De Barbanson B.;  Krenning L.;  Baron C.S.;  Tanenbaum M.E.;  Clevers H.;  Van Oudenaarden A.
收藏  |  浏览/下载：217/0  |  提交时间：2020/07/28
messenger RNA  dyes, reagents, indicators, markers and buffers  messenger RNA  uridine  cell component  differentiation  gene expression  metabolism  RNA  turnover  Article  cell cycle  cell differentiation  cell metabolism  gene cluster  gene control  gene expression  genetic transcription  human  intestinal stem cell  molecular dynamics  priority journal  regulatory mechanism  RNA sequencing  single cell analysis  animal  chemistry  K-562 cell line  metabolism  mouse  procedures  RNA stability  sequence analysis  single cell analysis  Mammalia  Animals  Humans  Indicators and Reagents  K562 Cells  Mice  RNA Stability  RNA, Messenger  Sequence Analysis, RNA  Single-Cell Analysis  Transcription, Genetic  Uridine  
Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Liu J.;  Kim Y.S.;  Richardson C.E.;  Tom A.;  Ramakrishnan C.;  Birey F.;  Katsumata T.;  Chen S.;  Wang C.;  Wang X.;  Joubert L.-M.;  Jiang Y.;  Wang H.;  Fenno L.E.;  Tok J.B.-H.;  Paşca S.P.;  Shen K.;  Bao Z.;  Deisseroth K.
收藏  |  浏览/下载：50/0  |  提交时间：2020/07/28
poly(3,4 ethylenedioxythiophene)  polyaniline  polymer  unclassified drug  3-nitro-o-phenylenediamine  aniline  aniline derivative  ascorbate peroxidase  nitro derivative  phenylenediamine derivative  polymer  anatomy  genetic engineering  membrane  physiological response  polymer  animal cell  Article  biocompatibility  brain nerve cell  brain slice  Caenorhabditis elegans  cell membrane  cell viability  controlled study  genetic procedures  genetically targeted chemical assemby  hippocampal neuronal culture  human  human cell  in vivo study  nerve cell membrane  nonhuman  polymerization  priority journal  rat  synthesis  action potential  animal  cell culture  cell survival  chemistry  electric conductivity  enzymology  genetic engineering  genetic transduction  genetics  HEK293 cell line  hippocampus  membrane potential  metabolism  motoneuron  mouse  muscle cell  nerve cell  patch clamp technique  physiology  Animalia  Action Potentials  Aniline Compounds  Animals  Ascorbate Peroxidases  Caenorhabditis elegans  Cell Membrane  Cell Survival  Cells, Cultured  Electric Conductivity  Genetic Engineering  HEK293 Cells  Hippocampus  Humans  Membrane Potentials  Mice  Motor Neurons  Muscle Cells  Neurons  Nitro Compounds  Patch-Clamp Techniques  Phenylenediamines  Polymers  Rats  Transduction, Genetic