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Mechanistic Study of Oxidoreductase AprQ Involved in Biosynthesis of Aminoglycoside Antibiotic Apramycin 期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2021, 卷号: 39, 期号: 7
作者:  Wang, Jinxiu;  Ma, Suze;  Ding, Wei;  Chen, Tuo;  Zhang, Qi
收藏  |  浏览/下载:26/0  |  提交时间:2022/04/28
ENZYME APRD4  BRANCH POINT  SPECIFICITY  NEOMYCIN  
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants 期刊论文
, 2020, 卷号: 368, 期号: 6488
作者:  Walton R.T.;  Christie K.A.;  Whittaker M.N.;  Kleinstiver B.P.
收藏  |  浏览/下载:27/0  |  提交时间:2020/07/28
adenine  adenosine  CRISPR associated endonuclease Cas9  cytosine  guanosine  SpG protein  SpRY nuclease  thymine  unclassified drug  Cas9 endonuclease Streptococcus pyogenes  bacterium  enzyme activity  genetic engineering  genetic variation  genome  Article  CRISPR-CAS9 system  DNA sequence  enzyme activity  gene editing  gene targeting  genetic variability  human  mutagenesis  nonhuman  priority journal  protein engineering  protein motif  protein structure  protospacer adjacent motif  Streptococcus pyogenes  chemistry  CRISPR Cas system  enzyme specificity  gene editing  gene targeting  genetic predisposition  genetics  HEK293 cell line  procedures  protein domain  Streptococcus pyogenes  CRISPR-Associated Protein 9  CRISPR-Cas Systems  Gene Editing  Gene Targeting  Genetic Predisposition to Disease  HEK293 Cells  Humans  Mutagenesis  Protein Domains  Substrate Specificity  
Peptide signaling for drought-induced tomato flower drop 期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:  Reichardt S.;  Piepho H.-P.;  Stintzi A.;  Schaller A.
收藏  |  浏览/下载:35/0  |  提交时间:2020/07/28
mitogen activated protein kinase  peptide hormone  phytaspase 2  phytosulfokine  unclassified drug  abscission  aspartic acid  crop yield  drought stress  enzyme activity  flower  fruit  gene expression  hormone  peptide  abscission  Arabidopsis  Article  bioassay  cell separation  controlled study  cytokine production  down regulation  drought  environmental stress  enzyme activity  enzyme specificity  ERF4 gene  ERT10 gene  flower  hydrolysis  hydrophobicity  IAA3 gene  immunomodulation  molecular dynamics  nonhuman  peptide signaling  PK7 gene  plant development  plant genome  priority journal  productivity  protein cleavage  protein degradation  protein expression  protein function  protein processing  regulator gene  signal transduction  tomato  TPRP gene  Lycopersicon esculentum  
Structure of an active human histone pre-mRNA 3′-end processing machinery 期刊论文
, 2020, 卷号: 367, 期号: 6478
作者:  Sun Y.;  Zhang Y.;  Aik W.S.;  Yang X.-C.;  Marzluff W.F.;  Walz T.;  Dominski Z.;  Tong L.
收藏  |  浏览/下载:220/0  |  提交时间:2020/07/28
beta lactamase  cleavage and polyadenylation specificity factor  cleavage and polyadenylation specificity factor 100  cleavage and polyadenylation specificity factor 73  endonuclease  histone  membrane protein  messenger RNA precursor  recombinant protein  small nuclear ribonucleoprotein  small nuclear RNA  symplekin  U7 small nuclear ribonucleoprotein  unclassified drug  enzyme activity  genetic analysis  metazoan  protein  recombination  RNA  3' untranslated region  amino terminal sequence  Article  biochemical analysis  carboxy terminal sequence  conformational transition  controlled study  cryoelectron microscopy  enzyme active site  gene rearrangement  genetic analysis  hydrogen bond  molecular recognition  mutagenesis  polyadenylation  priority journal  protein conformation  protein protein interaction  RNA cleavage  RNA processing  RNA sequencing  Amphora  Metazoa