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| Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者: Guthrie L.M.; Soma S.; Yuan S.; Silva A.; Zulkifli M.; Snavely T.C.; Greene H.F.; Nunez E.; Lynch B.; de Ville C.; Shanbhag V.; Lopez F.R.; Acharya A.; Petris M.J.; Kim B.-E.; Gohil V.M.; Sacchettini J.C.
  收藏 | 浏览/下载：38/0 | 提交时间：2020/07/28
copper copper zinc superoxide dismutase cytochrome c oxidase dopamine beta monooxygenase elesclomol monophenol monooxygenase protein lysine 6 oxidase copper cytochrome c oxidase elesclomol hydrazine derivative copper cytochrome enzyme enzyme activity mitochondrion mortality mutation pathology rodent survival animal cell animal experiment animal model animal tissue Article cohort analysis controlled study disease severity drug mechanism Golgi complex H9c2(2-1) cell line in vivo study male Menkes syndrome mitochondrial dynamics mortality rate mouse nerve degeneration nonhuman priority journal secretory pathway survival rate animal brain cell line degenerative disease disease model drug effect genetics knockout mouse Menkes syndrome metabolism mitochondrion pathology rat transport at the cellular level Murinae Mus Animals Biological Transport Brain Cell Line Copper Copper Transporter 1 Disease Models, Animal Electron Transport Complex IV Hydrazines Male Menkes Kinky Hair Syndrome Mice Mice, Knockout Mitochondria Neurodegenerative Diseases Rats |
| Meet the psychobiome 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者: Pennisi E.
收藏 | 浏览/下载：37/0 | 提交时间：2020/07/28
4 aminobutyric acid antibiotic agent dopamine kynurenine probiotic agent queuine serotonin psychotropic agent bacterium biome drug microbial activity nervous system disorder allergy Alzheimer disease antimicrobial therapy anxiety disorder archaeon Article autism bacterium culture Bacteroides blood brain barrier blood vessel brain disease clinical effectiveness constipation depression drug use enteroendocrine cell enteropathy entrepreneurship epilepsy fecal microbiota transplantation feces analysis Food and Drug Administration fungus genomics human insomnia intestine flora irritable colon mammal cell microbiology microbiome nerve cell nervous system nervous system development neurologic disease nonhuman obesity pain threshold Parkinson disease physician priority journal psychobiome psychological aspect psychological well-being schizophrenia scientist United States vagus nerve virus animal bacterium chemistry drug development intestine flora isolation and purification metabolism microbiology physiology procedures Animals Bacteria Drug Discovery Gastrointestinal Microbiome Humans Nervous System Diseases Psychotropic Drugs |
| Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者: Westbrook A.; van den Bosch R.; Määttä J.I.; Hofmans L.; Papadopetraki D.; Cools R.; Frank M.J.
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dopamine dopamine 2 receptor methylphenidate sulpiride dopamine dopamine 2 receptor blocking agent dopamine uptake inhibitor brain cost-benefit analysis decision making hormone sampling adult Article cognition cost benefit analysis decision making dopamine metabolism female gaze human human experiment male memory consolidation motivation normal human priority journal receptor blocking striate cortex task performance adolescent biosynthesis caudate nucleus cognition corpus striatum drug effect eye fixation memory metabolism reward saccadic eye movement signal transduction young adult Adolescent Caudate Nucleus Choice Behavior Cognition Corpus Striatum Decision Making Dopamine Dopamine D2 Receptor Antagonists Dopamine Uptake Inhibitors Female Fixation, Ocular Humans Male Memory Methylphenidate Motivation Reward Saccades Signal Transduction Sulpiride Young Adult |
| Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking 期刊论文
, 2020, 卷号: 368, 期号: 6487
作者: Lepack A.E.; Werner C.T.; Stewart A.F.; Fulton S.L.; Zhong P.; Farrelly L.A.; Smith A.C.W.; Ramakrishnan A.; Lyu Y.; Bastle R.M.; Martin J.A.; Mitra S.; O'Connor R.M.; Wang Z.-J.; Molina H.; Turecki G.; Shen L.; Yan Z.; Calipari E.S.; Dietz D.M.; Kenny P.J.; Maze I.
收藏 | 浏览/下载：51/0 | 提交时间：2020/07/28
amidase dopamine histone H3 histone transamidase protein glutamine gamma glutamyltransferase 2 RNA unclassified drug brain cell chemical compound chemical reaction gene expression genetic analysis protein action potential amino acid substitution amino terminal sequence Article cocaine dependence controlled study dopamine release dopaminergic nerve cell dopaminergic transmission down regulation drug seeking behavior enzyme activity gene expression histone dopaminylation histone modification human human tissue hyperpolarization in vitro study motivation nerve cell plasticity nerve projection neuropathology nucleus accumbens priority journal protein expression protein function reward RNA sequence ventral tegmentum Rattus |
| Genetics of schizophrenia in the South African Xhosa 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者: Gulsuner S.; Stein D.J.; Susser E.S.; Sibeko G.; Pretorius A.; Walsh T.; Majara L.; Mndini M.M.; Mqulwana S.G.; Ntola O.A.; Casadei S.; Ngqengelele L.L.; Korchina V.; Van Der Merwe C.; Malan M.; Fader K.M.; Feng M.; Willoughby E.; Muzny D.; Baldinger A.; Andrews H.F.; Gur R.C.; Gibbs R.A.; Zingela Z.; Nagdee M.; Ramesar R.S.; King M.-C.; McClellan J.M.
收藏 | 浏览/下载：41/0 | 提交时间：2020/07/28
4 aminobutyric acid dopamine glutamine genetic analysis genetic variation genome genomics mutagenicity mutation Article connectome controlled study gene mutation genetic variability genetics human major clinical study nerve cell plasticity priority journal schizophrenia South African Xhosa (people) South Africa |
| Local D2- To D1-neuron transmodulation updates goal-directed learning in the striatum 期刊论文
, 2020, 卷号: 367, 期号: 6477
作者: Matamales M.; McGovern A.E.; Mi J.D.; Mazzone S.B.; Balleine B.W.; Bertran-Gonzalez J.
收藏 | 浏览/下载：46/0 | 提交时间：2020/07/28
dopamine 1 receptor dopamine 2 receptor brain gene expression neurology phenotypic plasticity protein rodent adult animal experiment Article controlled study corpus striatum dopaminergic activity functional connectivity learning medium spiny neuron mouse nerve cell plasticity neuromodulation nonhuman nucleosome priority journal reinforcement Animalia Mus |
