气候变化领域集成服务门户(CCPortal): Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work

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DOI	10.1126/science.aaz5891
	Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work
	Westbrook A.; van den Bosch R.; Määttä J.I.; Hofmans L.; Papadopetraki D.; Cools R.; Frank M.J.
发表日期	2020
ISSN	0036-8075
起始页码	1362
结束页码	1366
卷号	367 期号:6484
英文摘要	Stimulants such as methylphenidate are increasingly used for cognitive enhancement but precise mechanisms are unknown. We found that methylphenidate boosts willingness to expend cognitive effort by altering the benefit-to-cost ratio of cognitive work. Willingness to expend effort was greater for participants with higher striatal dopamine synthesis capacity, whereas methylphenidate and sulpiride, a selective D2 receptor antagonist, increased cognitive motivation more for participants with lower synthesis capacity. A sequential sampling model informed by momentary gaze revealed that decisions to expend effort are related to amplification of benefit-versus-cost information attended early in the decision process, whereas the effect of benefits is strengthened with higher synthesis capacity and by methylphenidate. These findings demonstrate that methylphenidate boosts the perceived benefits versus costs of cognitive effort by modulating striatal dopamine signaling. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	dopamine dopamine 2 receptor methylphenidate sulpiride dopamine dopamine 2 receptor blocking agent dopamine uptake inhibitor brain cost-benefit analysis decision making hormone sampling adult Article cognition cost benefit analysis decision making dopamine metabolism female gaze human human experiment male memory consolidation motivation normal human priority journal receptor blocking striate cortex task performance adolescent biosynthesis caudate nucleus cognition corpus striatum drug effect eye fixation memory metabolism reward saccadic eye movement signal transduction young adult Adolescent Caudate Nucleus Choice Behavior Cognition Corpus Striatum Decision Making Dopamine Dopamine D2 Receptor Antagonists Dopamine Uptake Inhibitors Female Fixation, Ocular Humans Male Memory Methylphenidate Motivation Reward Saccades Signal Transduction Sulpiride Young Adult
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133617
推荐引用方式 GB/T 7714	Westbrook A.,van den Bosch R.,Määttä J.I.,et al. Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work[J]. Science,2020,367(6484).
APA	Westbrook A..,van den Bosch R..,Määttä J.I..,Hofmans L..,Papadopetraki D..,...&Frank M.J..(2020).Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work.,367(6484).
MLA	Westbrook A.,et al."Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work".367.6484(2020).