气候变化领域集成服务门户(CCPortal): Local D2- To D1-neuron transmodulation updates goal-directed learning in the striatum

CCPortal

DOI	10.1126/science.aaz5751
	Local D2- To D1-neuron transmodulation updates goal-directed learning in the striatum
	Matamales M.; McGovern A.E.; Mi J.D.; Mazzone S.B.; Balleine B.W.; Bertran-Gonzalez J.
发表日期	2020
ISSN	0036-8075
起始页码	549
结束页码	555
卷号	367 期号:6477
英文摘要	Extinction learning allows animals to withhold voluntary actions that are no longer related to reward and so provides a major source of behavioral control. Although such learning is thought to depend on dopamine signals in the striatum, the way the circuits that mediate goal-directed control are reorganized during new learning remains unknown. Here, by mapping a dopamine-dependent transcriptional activation marker in large ensembles of spiny projection neurons (SPNs) expressing dopamine receptor type 1 (D1-SPNs) or 2 (D2-SPNs) in mice, we demonstrate an extensive and dynamic D2- to D1-SPN transmodulation across the striatum that is necessary for updating previous goal-directed learning. Our findings suggest that D2-SPNs suppress the influence of outdated D1-SPN plasticity within functionally relevant striatal territories to reshape volitional action. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	dopamine 1 receptor dopamine 2 receptor brain gene expression neurology phenotypic plasticity protein rodent adult animal experiment Article controlled study corpus striatum dopaminergic activity functional connectivity learning medium spiny neuron mouse nerve cell plasticity neuromodulation nonhuman nucleosome priority journal reinforcement Animalia Mus
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133759
推荐引用方式 GB/T 7714	Matamales M.,McGovern A.E.,Mi J.D.,et al. Local D2- To D1-neuron transmodulation updates goal-directed learning in the striatum[J]. Science,2020,367(6477).
APA	Matamales M.,McGovern A.E.,Mi J.D.,Mazzone S.B.,Balleine B.W.,&Bertran-Gonzalez J..(2020).Local D2- To D1-neuron transmodulation updates goal-directed learning in the striatum.,367(6477).
MLA	Matamales M.,et al."Local D2- To D1-neuron transmodulation updates goal-directed learning in the striatum".367.6477(2020).