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VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance 期刊论文
, 2020, 卷号: 367, 期号: 6475
作者:  ElTanbouly M.A.;  Zhao Y.;  Nowak E.;  Li J.;  Schaafsma E.;  Le Mercier I.;  Ceeraz S.;  Lines J.L.;  Peng C.;  Carriere C.;  Huang X.;  Day M.;  Koehn B.;  Lee S.W.;  Morales M.S.;  Hogquist K.A.;  Jameson S.C.;  Mueller D.;  Rothstein J.;  Blazar B.R.;  Cheng C.;  Noelle R.J.
收藏  |  浏览/下载：56/0  |  提交时间：2020/07/28
cell protein  interferon  kruppel like factor 2  T lymphocyte receptor  unclassified drug  V type immunoglobulin domain containing suppressor of T cell activation protein  B7 antigen  Dies1 protein, mouse  lymphocyte antigen receptor  membrane protein  monoclonal antibody  VSIR protein, human  biological development  cell  gene expression  heterogeneity  homeostasis  immune response  immunity  tolerance  acute graft versus host disease  animal cell  animal experiment  animal model  Article  CD4+ T lymphocyte  cell death  cell expansion  cell fate  cell heterogeneity  cell loss  cell survival  controlled study  female  gene  gene deletion  homeostasis  immunological tolerance  in vivo study  long term survival  male  mouse  nonhuman  phenotype  priority journal  protein expression  protein function  rheumatoid arthritis  RNA sequencing  systemic lupus erythematosus  T lymphocyte  T lymphocyte activation  T lymphocyte subpopulation  TCR gene  upregulation  VISTA gene  animal  C57BL mouse  genetics  immunological tolerance  immunology  knockout mouse  lymphocyte activation  physiology  T lymphocyte  Mus  Animals  Antibodies, Monoclonal  B7 Antigens  Lymphocyte Activation  Membrane Proteins  Mice  Mice, Inbred C57BL  Mice, Knockout  Peripheral Tolerance  Receptors, Antigen, T-Cell  T-Lymphocytes  
CRISPR-engineered T cells in patients with refractory cancer 期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:  Stadtmauer E.A.;  Fraietta J.A.;  Davis M.M.;  Cohen A.D.;  Weber K.L.;  Lancaster E.;  Mangan P.A.;  Kulikovskaya I.;  Gupta M.;  Chen F.;  Tian L.;  Gonzalez V.E.;  Xu J.;  Jung I.-Y.;  Joseph Melenhorst J.;  Plesa G.;  Shea J.;  Matlawski T.;  Cervini A.;  Gaymon A.L.;  Desjardins S.;  Lamontagne A.;  Salas-Mckee J.;  Fesnak A.;  Siegel D.L.;  Levine B.L.;  Jadlowsky J.K.;  Young R.M.;  Chew A.;  Hwang W.-T.;  Hexner E.O.;  Carreno B.M.;  Nobles C.L.;  Bushman F.D.;  Parker K.R.;  Qi Y.;  Satpathy A.T.;  Chang H.Y.;  Zhao Y.;  Lacey S.F.;  June C.H.
收藏  |  浏览/下载：46/0  |  提交时间：2020/07/28
heterodimer  programmed death 1 receptor  T lymphocyte receptor alpha chain  T lymphocyte receptor beta chain  cancer  cell  gene  gene expression  genetic engineering  immunity  protein  adult  aged  Article  cancer patient  cell engineering  chromosome translocation  clinical article  clustered regularly interspaced short palindromic repeat  controlled study  CRISPR-CAS9 system  feasibility study  female  gene editing  gene expression  gene frequency  gene locus  genetic code  human  human cell  male  middle aged  myeloma  PDCD1 gene  phase 1 clinical trial  priority journal  sarcoma  T lymphocyte  TRAC gene  TRBC gene  tumor immunity  
De novo design of protein logic gates 期刊论文
, 2020, 卷号: 368, 期号: 6486
作者:  Chen Z.;  Kibler R.D.;  Hunt A.;  Busch F.;  Pearl J.;  Jia M.;  VanAernum Z.L.;  Wicky B.I.M.;  Dods G.;  Liao H.;  Wilken M.S.;  Ciarlo C.;  Green S.;  El-Samad H.;  Stamatoyannopoulos J.;  Wysocki V.H.;  Jewett M.C.;  Boyken S.E.;  Baker D.
收藏  |  浏览/下载：31/0  |  提交时间：2020/07/28
cell  design method  gene expression  genetic analysis  protein  activation domain  Article  binding affinity  circular dichroism  controlled study  de novo design  design  DNA binding motif  enzyme activity  genetic transcription  human  human cell  hydrogen bond  hydrophobicity  mass spectrometry  native mass spectrometry  nonhuman  priority journal  protein protein interaction  protein structure  RNA translation  stoichiometry  thermodynamics  two hybrid system  X ray crystallography  chemistry  genetics  logic  metabolism  protein analysis  protein engineering  protein processing  synthetic biology  T lymphocyte  yeast  HAVCR2 protein, human  hepatitis A virus cellular receptor 2  Hepatitis A Virus Cellular Receptor 2  Humans  Logic  Mass Spectrometry  Protein Engineering  Protein Interaction Maps  Protein Processing, Post-Translational  Synthetic Biology  T-Lymphocytes  Transcription, Genetic  Yeasts  
A cell atlas of human thymic development defines T cell repertoire formation 期刊论文
, 2020, 卷号: 367, 期号: 6480
作者:  Park J.-E.;  Botting R.A.;  Conde C.D.;  Popescu D.-M.;  Lavaert M.;  Kunz D.J.;  Goh I.;  Stephenson E.;  Ragazzini R.;  Tuck E.;  Wilbrey-Clark A.;  Roberts K.;  Kedlian V.R.;  Ferdinand J.R.;  He X.;  Webb S.;  Maunder D.;  Vandamme N.;  Mahbubani K.T.;  Polanski K.;  Mamanova L.;  Bolt L.;  Crossland D.;  De Rita F.;  Fuller A.;  Filby A.;  Reynolds G.;  Dixon D.;  Saeb-Parsy K.;  Lisgo S.;  Henderson D.;  Vento-Tormo R.;  Bayraktar O.A.;  Barker R.A.;  Meyer K.B.;  Saeys Y.;  Bonfanti P.;  Behjati S.;  Clatworthy M.R.;  Taghon T.;  Haniffa M.;  Teichmann S.A.
收藏  |  浏览/下载：69/0  |  提交时间：2020/07/28
T lymphocyte receptor  cell component  developmental biology  differentiation  genomics  recombination  RNA  adaptive immunity  Article  CD4+ T lymphocyte  CD8+ T lymphocyte  cell fate  cell maturation  cell selection  controlled study  developmental stage  gene  gene expression  gene expression profiling  GNG4 gene  human  human cell  human tissue  lymphocyte differentiation  priority journal  protein expression  regulatory T lymphocyte  RNA sequencing  sequence analysis  T lymphocyte  T lymphocyte activation  thymic medulla  thymocyte  thymus  XCL1 gene  
MRNA destabilization by BTG1 and BTG2 maintains T cell quiescence 期刊论文
, 2020, 卷号: 367, 期号: 6483
作者:  Hwang S.S.;  Lim J.;  Yu Z.;  Kong P.;  Sefik E.;  Xu H.;  Harman C.C.D.;  Kim L.K.;  Lee G.R.;  Li H.-B.;  Flavell R.A.
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/28
CD69 antigen  chemokine receptor CCR7  epidermal growth factor receptor 2  Hermes antigen  interleukin 2 receptor alpha  interleukin 2 receptor gamma  interleukin 7 receptor  kruppel like factor 2  messenger RNA  polyadenylic acid  T lymphocyte receptor  transcription factor FKHR  transcriptome  biodegradation  cell component  RNA  adenylation  Article  BTG1 gene  BTG2 gene  Ccr7 gene  CD4+ T lymphocyte  CD8+ T lymphocyte  cell differentiation  cell expansion  cell maturation  cell migration  cell proliferation  cell size  cell specificity  cell survival  controlled study  CRISPR-CAS9 system  flow cytometry  gene  gene control  gene expression  gene function  gene identification  immunoprecipitation  in vitro study  in vivo study  memory T lymphocyte  nonhuman  phylogenetic tree  priority journal  RNA degradation  RNA sequencing  S1pr1 gene  Sell gene  spleen  T lymphocyte  T lymphocyte activation  tail length (comet assay)  thymus  upregulation