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Loss of phosphatidylserine flippase beta-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis 期刊论文
DISEASE MODELS & MECHANISMS, 2021, 卷号: 14, 期号: 6
作者:  Liu, Wenjing;  Peng, Lei;  Tian, Wanli;  Li, Yi;  Zhang, Ping;  Sun, Kuanxiang;  Yang, Yeming;  Li, Xiao;  Li, Guisen;  Zhu, Xianjun
收藏  |  浏览/下载：36/0  |  提交时间：2022/04/28
ENDOPLASMIC-RETICULUM STRESS  FOCAL SEGMENTAL GLOMERULOSCLEROSIS  SUBCELLULAR-LOCALIZATION  VIABLE PODOCYTES  EPITHELIAL-CELLS  MESANGIAL CELL  CDC50 PROTEINS  MOUSE MODELS  EXPRESSION  NEPHROPATHY  
Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice 期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:  Guthrie L.M.;  Soma S.;  Yuan S.;  Silva A.;  Zulkifli M.;  Snavely T.C.;  Greene H.F.;  Nunez E.;  Lynch B.;  de Ville C.;  Shanbhag V.;  Lopez F.R.;  Acharya A.;  Petris M.J.;  Kim B.-E.;  Gohil V.M.;  Sacchettini J.C.
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/28
copper  copper zinc superoxide dismutase  cytochrome c oxidase  dopamine beta monooxygenase  elesclomol  monophenol monooxygenase  protein lysine 6 oxidase  copper  cytochrome c oxidase  elesclomol  hydrazine derivative  copper  cytochrome  enzyme  enzyme activity  mitochondrion  mortality  mutation  pathology  rodent  survival  animal cell  animal experiment  animal model  animal tissue  Article  cohort analysis  controlled study  disease severity  drug mechanism  Golgi complex  H9c2(2-1) cell line  in vivo study  male  Menkes syndrome  mitochondrial dynamics  mortality rate  mouse  nerve degeneration  nonhuman  priority journal  secretory pathway  survival rate  animal  brain  cell line  degenerative disease  disease model  drug effect  genetics  knockout mouse  Menkes syndrome  metabolism  mitochondrion  pathology  rat  transport at the cellular level  Murinae  Mus  Animals  Biological Transport  Brain  Cell Line  Copper  Copper Transporter 1  Disease Models, Animal  Electron Transport Complex IV  Hydrazines  Male  Menkes Kinky Hair Syndrome  Mice  Mice, Knockout  Mitochondria  Neurodegenerative Diseases  Rats  
Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception 期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:  Chong E.;  Moroni M.;  Wilson C.;  Shoham S.;  Panzeri S.;  Rinberg D.
收藏  |  浏览/下载：18/0  |  提交时间：2020/07/28
odor  olfactory cue  perception  sensory system  spatiotemporal analysis  Mus  bacterial protein  channelrhodopsin  fragrance  olfactory marker protein  photoprotein  yellow fluorescent protein, Bacteria  animal  biological model  cytology  genetics  mouse  odor  olfactory bulb  optogenetics  physiology  smelling  spatiotemporal analysis  Animals  Bacterial Proteins  Channelrhodopsins  Luminescent Proteins  Mice  Models, Neurological  Odorants  Olfactory Bulb  Olfactory Marker Protein  Olfactory Perception  Optogenetics  Smell  Spatio-Temporal Analysis  
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2 期刊论文
, 2020, 卷号: 368, 期号: 6496
作者:  Wu Y.;  Wang F.;  Shen C.;  Peng W.;  Li D.;  Zhao C.;  Li Z.;  Li S.;  Bi Y.;  Yang Y.;  Gong Y.;  Xiao H.;  Fan Z.;  Tan S.;  Wu G.;  Tan W.;  Lu X.;  Fan C.;  Wang Q.;  Liu Y.;  Zhang C.;  Qi J.;  Gao G.F.;  Gao F.;  Liu L.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/28
Coronavirus  angiotensin converting enzyme 2  coronavirus spike glycoprotein  dipeptidyl carboxypeptidase  epitope  monoclonal antibody  neutralizing antibody  virus antibody  virus receptor  animal  chemistry  Coronavirus infection  disease model  human  immunology  isolation and purification  lung  mouse  pandemic  protein domain  serodiagnosis  virology  virus load  virus pneumonia  Animals  Antibodies, Monoclonal  Antibodies, Neutralizing  Antibodies, Viral  Coronavirus Infections  Disease Models, Animal  Humans  Immunodominant Epitopes  Lung  Mice  Neutralization Tests  Pandemics  Peptidyl-Dipeptidase A  Pneumonia, Viral  Protein Domains  Receptors, Virus  Spike Glycoprotein, Coronavirus  Viral Load