气候变化领域集成服务门户(CCPortal): Loss of phosphatidylserine flippase beta-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis

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DOI	10.1242/dmm.048777
	Loss of phosphatidylserine flippase beta-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis
	Liu, Wenjing; Peng, Lei; Tian, Wanli; Li, Yi; Zhang, Ping; Sun, Kuanxiang; Yang, Yeming; Li, Xiao; Li, Guisen; Zhu, Xianjun
通讯作者	Zhu, XJ (通讯作者)，Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Hlth Management Ctr, Sch Med, Chengdu 610072, Sichuan, Peoples R China. ; Zhu, XJ (通讯作者)，Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Ctr Med Genet, Sichuan Prov Key Lab Human Dis Gene Study, Chengdu 610072, Sichuan, Peoples R China. ; Li, GS (通讯作者)，Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Sichuan Clin Res Ctr Kidney Dis, Dept Nephrol, Chengdu 610072, Sichuan, Peoples R China. ; Zhu, XJ (通讯作者)，Chinese Acad Sci, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China. ; Zhu, XJ (通讯作者)，Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China. ; Zhu, XJ (通讯作者)，Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Res Unit Blindness Prevent Chinese Acad Med Sci 2, Chengdu 610072, Sichuan, Peoples R China. ; Zhu, XJ (通讯作者)，Shangqiu First Peoples Hosp, Dept Ophthalmol, Shangqiu 476000, Henan, Peoples R China. ; Zhu, XJ (通讯作者)，Chinese Acad Sci, Sichuan Translat Med Hosp, Nat Prod Res Ctr, Inst Chengdu Biol, Chengdu 610072, Sichuan, Peoples R China.
发表日期	2021
ISSN	1754-8403
EISSN	1754-8411
卷号	14 期号:6
英文摘要	The asymmetric distribution of phosphatidylserine (PS) in the cytoplasmic leaflet of eukaryotic cell plasma membranes is regulated by a group of P4-ATPases (named PS flippases) and the 0-subunit TMEM30A. Podocytes in the glomerulus form a filtration barrier to prevent the traversing of large cellular elements and macromolecules from the blood into the urinary space. Damage to podocytes can disrupt the filtration barrier and lead to proteinuria and podocytopathy. We observed reduced TMEM30A expression in patients with minimal change disease and membranous nephropathy, indicating potential roles of TMEM30A in podocytopathy. To investigate the role of Tmem30a in the kidney, we generated a podocyte-specific Tmem30a knockout (KO) mouse model using the NPHS2-Cre line. Tmem30a KO mice displayed albuminuria, podocyte degeneration, mesangial cell proliferation with prominent extracellular matrix accumulation and eventual progression to focal segmental glomerulosclerosis. Our data demonstrate a critical role of Tmem30a in maintaining podocyte survival and glomerular filtration barrier integrity. Understanding the dynamic regulation of the PS distribution in the glomerulus provides a unique perspective to pinpointing the mechanism of podocyte damage and potential therapeutic targets.
关键词	ENDOPLASMIC-RETICULUM STRESS FOCAL SEGMENTAL GLOMERULOSCLEROSIS SUBCELLULAR-LOCALIZATION VIABLE PODOCYTES EPITHELIAL-CELLS MESANGIAL CELL CDC50 PROTEINS MOUSE MODELS EXPRESSION NEPHROPATHY
英文关键词	Tmem30a; Albuminuria; Focal segmental glomerulosclerosis; Glomerulosclerosis
语种	英语
WOS研究方向	Cell Biology ; Pathology
WOS类目	Cell Biology ; Pathology
WOS记录号	WOS:000669586000004
来源期刊	DISEASE MODELS & MECHANISMS
来源机构	中国科学院西北生态环境资源研究院
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/255173
作者单位	[Liu, Wenjing; Tian, Wanli; Sun, Kuanxiang; Yang, Yeming; Li, Xiao; Zhu, Xianjun] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Hlth Management Ctr, Sch Med, Chengdu 610072, Sichuan, Peoples R China; [Liu, Wenjing; Zhu, Xianjun] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Ctr Med Genet, Sichuan Prov Key Lab Human Dis Gene Study, Chengdu 610072, Sichuan, Peoples R China; [Peng, Lei; Li, Yi; Zhang, Ping; Li, Guisen] Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Sichuan Clin Res Ctr Kidney Dis, Dept Nephrol, Chengdu 610072, Sichuan, Peoples R China; [Zhu, Xianjun] Chinese Acad Sci, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China; [Zhu, Xianjun] Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China; [Zhu, Xianjun] Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Res Unit Blindness Prevent Chinese Acad Med Sci 2, Chengdu 610072, Sichuan, Peoples R China; [Zhu, Xianjun] Shangqiu First Peoples Hosp, Dept Ophtha...
推荐引用方式 GB/T 7714	Liu, Wenjing,Peng, Lei,Tian, Wanli,et al. Loss of phosphatidylserine flippase beta-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis[J]. 中国科学院西北生态环境资源研究院,2021,14(6).
APA	Liu, Wenjing.,Peng, Lei.,Tian, Wanli.,Li, Yi.,Zhang, Ping.,...&Zhu, Xianjun.(2021).Loss of phosphatidylserine flippase beta-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis.DISEASE MODELS & MECHANISMS,14(6).
MLA	Liu, Wenjing,et al."Loss of phosphatidylserine flippase beta-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis".DISEASE MODELS & MECHANISMS 14.6(2021).