气候变化领域集成服务门户(CCPortal): Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception

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DOI	10.1126/science.aba2357
	Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception
	Chong E.; Moroni M.; Wilson C.; Shoham S.; Panzeri S.; Rinberg D.
发表日期	2020
ISSN	0036-8075
卷号	368 期号:6497
英文摘要	How does neural activity generate perception? Finding the combinations of spatial or temporal activity features (such as neuron identity or latency) that are consequential for perception remains challenging. We trained mice to recognize synthetic odors constructed from parametrically defined patterns of optogenetic activation, then measured perceptual changes during extensive and controlled perturbations across spatiotemporal dimensions. We modeled recognition as the matching of patterns to learned templates. The templates that best predicted recognition were sequences of spatially identified units, ordered by latencies relative to each other (with minimal effects of sniff). Within templates, individual units contributed additively, with larger contributions from earlier-activated units. Our synthetic approach reveals the fundamental logic of the olfactory code and provides a general framework for testing links between sensory activity and perception. © 2020 American Association for the Advancement of Science. All rights reserved.
关键词	odor olfactory cue perception sensory system spatiotemporal analysis Mus bacterial protein channelrhodopsin fragrance olfactory marker protein photoprotein yellow fluorescent protein, Bacteria animal biological model cytology genetics mouse odor olfactory bulb optogenetics physiology smelling spatiotemporal analysis Animals Bacterial Proteins Channelrhodopsins Luminescent Proteins Mice Models, Neurological Odorants Olfactory Bulb Olfactory Marker Protein Olfactory Perception Optogenetics Smell Spatio-Temporal Analysis
语种	英语
来源机构	Science
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/133418
推荐引用方式 GB/T 7714	Chong E.,Moroni M.,Wilson C.,et al. Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception[J]. Science,2020,368(6497).
APA	Chong E.,Moroni M.,Wilson C.,Shoham S.,Panzeri S.,&Rinberg D..(2020).Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception.,368(6497).
MLA	Chong E.,et al."Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception".368.6497(2020).