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High-mass MALDI-MS unravels ligand-mediated G protein-coupling selectivity to GPCRs 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 31
作者:  Wu N.;  Olechwier A.M.;  Brunner C.;  Edwards P.C.;  Tsai C.-J.;  Tate C.G.;  Schertler G.F.X.;  Schneider G.;  Deupi X.;  Zenobi R.;  Ma P.
收藏  |  浏览/下载：17/0  |  提交时间：2022/02/22
Structural basis of Gs and Gi recognition by the human glucagon receptor 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Qiao A.;  Han S.;  Li X.;  Li Z.;  Zhao P.;  Dai A.;  Chang R.;  Tai L.;  Tan Q.;  Chu X.;  Ma L.;  Thorsen T.S.;  Reedtz-Runge S.;  Yang D.;  Wang M.-W.;  Sexton P.M.;  Wootten D.;  Sun F.;  Zhao Q.;  Wu B.
收藏  |  浏览/下载：32/0  |  提交时间：2020/07/28
cyclic AMP  glucagon  glucagon receptor  inhibitory guanine nucleotide binding protein  stimulatory guanine nucleotide binding protein  glucagon receptor  inhibitory guanine nucleotide binding protein  protein binding  stimulatory guanine nucleotide binding protein  chemical binding  enzyme activity  gene expression  mutagenicity  protein  alpha helix  Article  binding affinity  carboxy terminal sequence  conformational transition  cryoelectron microscopy  human  molecular recognition  mutagenesis  priority journal  protein binding  protein function  protein protein interaction  protein structure  signal transduction  binding site  chemistry  metabolism  molecular model  protein conformation  ultrastructure  Binding Sites  Cryoelectron Microscopy  Glucagon  GTP-Binding Protein alpha Subunits, Gi-Go  GTP-Binding Protein alpha Subunits, Gs  Humans  Models, Molecular  Protein Binding  Protein Conformation  Protein Conformation, alpha-Helical  Receptors, Glucagon  Signal Transduction  
Determination of the melanocortin-4 receptor structure identifies Ca2+ as a cofactor for ligand binding 期刊论文
, 2020, 卷号: 368, 期号: 6489
作者:  Yu J.;  Gimenez L.E.;  Hernandez C.C.;  Wu Y.;  Wein A.H.;  Han G.W.;  McClary K.;  Mittal S.R.;  Burdsall K.;  Stauch B.;  Wu L.;  Stevens S.N.;  Peisley A.;  Williams S.Y.;  Chen V.;  Millhauser G.L.;  Zhao S.;  Cone R.D.;  Stevens R.C.
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/28
alpha intermedin  calcium ion  cyclic AMP  G protein coupled receptor  heterotrimeric guanine nucleotide binding protein  inwardly rectifying potassium channel  inwardly rectifying potassium channel subunit Kir7.1  melanocortin 4 receptor  n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide]  unclassified drug  calcium  G protein coupled receptor  intermedin  inwardly rectifying potassium channel  Kir7.1 channel  ligand  melanocortin 4 receptor  n acetyl alpha intermedin[4-10]cyclo[4 norleucine 5 aspartic acid 7 [3 (2 naphthyl)alanine] 10 lysinamide]  protein binding  calcium  chemical binding  homeostasis  hormone  ligand  obesity  peptide  protein  Article  binding affinity  complex formation  crystallization  drug structure  extracellular calcium  human  ligand binding  priority journal  protein structure  receptor blocking  signal transduction  chemistry  genetics  mutation  protein multimerization  protein secondary structure  X ray crystallography  Calcium  Crystallography, X-Ray  Cyclic AMP  Humans  Ligands  Melanocyte-Stimulating Hormones  Mutation  Potassium Channels, Inwardly Rectifying  Protein Binding  Protein Multimerization  Protein Structure, Secondary  Receptor, Melanocortin, Type 4  Receptors, G-Protein-Coupled  Signal Transduction  
G alpha(i1) and G alpha(i3) regulate macrophage polarization by forming a complex containing CD14 and Gab1 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 卷号: 112, 期号: 15, 页码: 4731-4736
作者:  Li, Xianjing;  Wang, Duowei;  Chen, Zhen;  Lu, Ermei;  Wang, Zhuo;  Duan, Jingjing;  Tian, Wei;  Wang, Yun;  You, Linjun;  Zou, Yulian;  Cheng, Yan;  Zhu, Qingyi;  Wan, Xiaojian;  Xi, Tao;  Birnbaumerd, Lutz;  Yang, Yong
收藏  |  浏览/下载：30/0  |  提交时间：2019/05/04
Movement of retinal along the visual transduction path 期刊论文
Science, 2000, 卷号: 288, 期号: 5474
作者:  Borhan B.;  Souto M.L.;  Imai H.;  Shichida Y.;  Nakanishi K.
收藏  |  浏览/下载：26/0  |  提交时间：2022/01/14
Degradation of Gα by the N-end rule pathway 期刊论文
Science, 1994, 卷号: 265, 期号: 5177
作者:  Madura K.;  Varshavsky A.
收藏  |  浏览/下载：1/0  |  提交时间：2022/01/14