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The anti-liver fibrosis effect of Tibetan medicine (Qiwei Tiexie capsule) is related to the inhibition of NLRP3 inflammasome activation in vivo and in vitro 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2024, 卷号: 319
作者:  Wang, Shanshan;  Ye, Fei;  Ren, Qingjia;  Sun, Shengnan;  Xia, Weina;  Wang, Zhuwei;  Guo, Haolin;  Li, Han;  Zhang, Shujing;  Lowe, Scott;  Chen, Meng;  Du, Qinghong;  Li, Weihong
收藏  |  浏览/下载：38/0  |  提交时间：2024/03/01
Tibetan medicine  Qiwei tiexie capsule  Liver fibrosis  Inflammation  NLRP3 inflammasome  
Integrated network toxicology, molecular docking, and in vivo experiments to elucidate molecular mechanism of aflatoxin B1 hepatotoxicity 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2024, 卷号: 275
收藏  |  浏览/下载：5/0  |  提交时间：2024/06/11
Manganese nutrient mitigates ammonia, arsenic toxicity and high temperature stress using gene regulation via NFkB mechanism in fish 期刊论文
SCIENTIFIC REPORTS, 2024, 卷号: 14, 期号: 1
收藏  |  浏览/下载：5/0  |  提交时间：2024/06/11
Multifunctional role of dietary copper to regulate stress-responsive gene for mitigation of multiple stresses in Pangasianodon hypophthalmus 期刊论文
SCIENTIFIC REPORTS, 2024, 卷号: 14, 期号: 1
收藏  |  浏览/下载：3/0  |  提交时间：2024/06/11
Integrating UPLC-Q-Exactive Orbitrap/MS, network pharmacology and experimental validation to reveal the potential mechanism of Tibetan medicine Rhodiola granules in improving myocardial ischemia-reperfusion injury 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2023, 卷号: 314
作者:  Xing, Nan;  Qin, Jing;  Ren, Dongsheng;  Du, Qinyun;  Li, Yuying;  Mi, Jiao;  Zhang, Fengming;  Ai, Li;  Zhang, Sanyin;  Zhang, Yi;  Wang, Shaohui
收藏  |  浏览/下载：29/0  |  提交时间：2024/03/01
UPLC-Q-exactive orbitrap  MS  Network pharmacology  Rhodiola granules  Myocardial ischemia-reperfusion injury  Experimental validation  
Profiles of messenger RNAs and MicroRNAs in hypoxia-induced hepatic stellate cells 期刊论文
ANNALS OF TRANSLATIONAL MEDICINE, 2021, 卷号: 9, 期号: 18
作者:  Zhang, Liting;  Gao, Jing;  Zhou, Dan;  Wang, Xiaojun;  Li, Junfeng;  Wang, Juan;  Chen, Hong;  Xie, Xiaodong;  Chen, Tuo
收藏  |  浏览/下载：42/0  |  提交时间：2022/04/28
INDUCIBLE FACTORS  ACTIVATION  PATHWAY  EXPRESSION  
Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 9
作者:  Wang M.-Y.;  Dean E.D.;  Quittner-Strom E.;  Zhu Y.;  Chowdhury K.H.;  Zhang Z.;  Zhao S.;  Li N.;  Ye R.;  Lee Y.;  Zhang Y.;  Chen S.;  Yu X.;  Leonard D.C.;  Poffenberger G.;  Deylen A.V.;  McCorkle S.K.;  Schlegel A.;  Sloop K.W.;  Efanov A.M.;  Gimeno R.E.;  Scherer P.E.;  Powers A.C.;  Unger R.H.;  Holland W.L.
收藏  |  浏览/下载：51/0  |  提交时间：2021/05/24
Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 12
作者:  Rayo J.;  Gregor R.;  Jacob N.T.;  Dandela R.;  Dubinsky L.;  Yashkin A.;  Aranovich A.;  Thangaraj M.;  Ernst O.;  Barash E.;  Malitsky S.;  Florea B.I.;  Krom B.P.;  Wiemer E.A.C.;  Kickhoefer V.A.;  Rome L.H.;  Mathison J.C.;  Kaufmann G.F.;  Overkleeft H.S.;  Cravatt B.F.;  Zor T.;  Janda K.D.;  Ulevitch R.J.;  Kravchenko V.V.;  Meijler M.M.
收藏  |  浏览/下载：55/0  |  提交时间：2021/05/24
JNK signaling prevents biliary cyst formation through a CASPASE-8–dependent function of RIPK1 during aging 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2021, 卷号: 118, 期号: 12
作者:  Müller K.;  Honcharova-Biletska H.;  Koppe C.;  Egger M.;  Chan L.K.;  Schneider A.T.;  Küsgens L.;  Böhm F.;  Boege Y.;  Healy M.E.;  Schmitt J.;  Comtesse S.;  Castoldi M.;  Preisinger C.;  Szydlowska M.;  Focaccia E.;  Gaisa N.T.;  Loosen S.H.;  Jörs S.;  Tacke F.;  Roderburg C.;  Keitel V.;  Bode J.G.;  Boor P.;  Davis R.J.;  Longerich T.;  Geisler F.;  Heikenwalder M.;  Weber A.;  Vucur M.;  Luedde T.
收藏  |  浏览/下载：285/0  |  提交时间：2021/05/24
CFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation 期刊论文
, 2020, 卷号: 367, 期号: 6484
作者:  Muendlein H.I.;  Jetton D.;  Connolly W.M.;  Eidell K.P.;  Magri Z.;  Smirnova I.;  Poltorak A.
收藏  |  浏览/下载：57/0  |  提交时间：2020/07/28
FLICE inhibitory protein  interleukin 1beta  lipopolysaccharide  messenger RNA  succinate dehydrogenase (ubiquinone)  Casp1 protein, mouse  caspase 8  Cflar protein, mouse  cryopyrin  FLICE inhibitory protein  IL1B protein, mouse  inflammasome  interleukin 1beta  interleukin 1beta converting enzyme  lipopolysaccharide  succinate dehydrogenase (ubiquinone)  cell  enzyme activity  inhibition  maturation  protein  animal cell  animal experiment  Article  bone marrow derived macrophage  cell death  cell protection  complex formation  controlled study  cytokine release  in vitro study  inflammation  mouse  nonhuman  priority journal  protein analysis  protein degradation  protein function  protein interaction  pyroptosis  animal  gene knockdown  genetics  immunology  macrophage  macrophage activation  metabolism  physiology  Murinae  Animals  CASP8 and FADD-Like Apoptosis Regulating Protein  Caspase 1  Caspase 8  Electron Transport Complex II  Gene Knockdown Techniques  Inflammasomes  Interleukin-1beta  Lipopolysaccharides  Macrophage Activation  Macrophages  Mice  NLR Family, Pyrin Domain-Containing 3 Protein  Pyroptosis