气候变化领域集成服务门户(CCPortal): Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones

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DOI	10.1073/pnas.2012529118
	Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones
	Rayo J.; Gregor R.; Jacob N.T.; Dandela R.; Dubinsky L.; Yashkin A.; Aranovich A.; Thangaraj M.; Ernst O.; Barash E.; Malitsky S.; Florea B.I.; Krom B.P.; Wiemer E.A.C.; Kickhoefer V.A.; Rome L.H.; Mathison J.C.; Kaufmann G.F.; Overkleeft H.S.; Cravatt B.F.; Zor T.; Janda K.D.; Ulevitch R.J.; Kravchenko V.V.; Meijler M.M.
发表日期	2021
ISSN	00278424
卷号	118 期号:12
英文摘要	The major vault protein (MVP) mediates diverse cellular responses, including cancer cell resistance to chemotherapy and protection against inflammatory responses to Pseudomonas aeruginosa. Here, we report the use of photoactive probes to identify MVP as a target of the N-(3-oxo-dodecanoyl) homoserine lactone (C12), a quorum sensing signal of certain proteobacteria including P. aeruginosa. A treatment of normal and cancer cells with C12 or other N-acyl homoserine lactones (AHLs) results in rapid translocation of MVP into lipid raft (LR) membrane fractions. Like AHLs, inflammatory stimuli also induce LR-localization of MVP, but the C12 stimulation reprograms (functionalizes) bioactivity of the plasma membrane by recruiting death receptors, their apoptotic adaptors, and caspase-8 into LR. These functionalized membranes control AHL-induced signaling processes, in that MVP adjusts the protein kinase p38 pathway to attenuate programmed cell death. Since MVP is the structural core of large particles termed vaults, our findings suggest a mechanism in which MVP vaults act as sentinels that fine-tune inflammation-activated processes such as apoptotic signaling mediated by immunosurveillance cytokines including tumor necrosis factor-related apoptosis inducing ligand (TRAIL). © 2021 National Academy of Sciences. All rights reserved.
英文关键词	Bacterial signaling \| immunoediting \| cross-kingdom communication immunosurveillance
语种	英语
scopus关键词	caspase 8; death receptor; lung resistance protein; mitogen activated protein kinase p38; n (3 oxo dodecanoyl)homoserine lactone; n acylhomoserine lactone; unclassified drug; apoptosis; Article; bacterium identification; cancer cell; cell membrane; controlled study; human; human cell; immunological parameters; inflammation; lipid membrane; molecular probe; nonhuman; priority journal; protein analysis; protein function; protein structure; protein targeting; protein transport; Pseudomonas aeruginosa; quorum sensing; signal transduction
来源期刊	Proceedings of the National Academy of Sciences of the United States of America
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/180172
作者单位	Department of Chemistry, National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Be’er Sheva, 8410501, Israel; Department of Immunology and Microbial Sciences, Scripps Research Institute, San Diego, CA 92037, United States; Department of Chemistry, Skaggs Institute forChemical Biology, Scripps Research Institute, San Diego, CA 92037, United States; The Worm Institute of Research and Medicine, Scripps Research Institute, San Diego, CA92037, United States; Department of Biochemistry & Molecular Biology, Life Sciences Institute, Tel Aviv University, Tel Aviv, 69978, Israel; Department of ComputerScience, Ben-Gurion University of the Negev, Be’er Sheva, 8410501, Israel; Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, 7610001, Israel; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, 2333 ZA, Netherlands; Department of PreventiveDentistry, Academic Centre for Dentistry, Amsterdam, 1081 LA, Netherlands; Departme...
推荐引用方式 GB/T 7714	Rayo J.,Gregor R.,Jacob N.T.,et al. Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones[J],2021,118(12).
APA	Rayo J..,Gregor R..,Jacob N.T..,Dandela R..,Dubinsky L..,...&Meijler M.M..(2021).Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones.Proceedings of the National Academy of Sciences of the United States of America,118(12).
MLA	Rayo J.,et al."Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones".Proceedings of the National Academy of Sciences of the United States of America 118.12(2021).